황금 추출물이 생쥐에 유발된 접촉피부염의 피부 증상에 미치는 영향
Effects of Scutellaria baicalensis Extract on Skin Lesion of Contact Dermatitis induced by DNFB in Mice
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Scutellaria baicalensis Georgi is one of major herbs used to treat patients with skin diseases diagnosed by wind-heat syndrome. This study was designed to investigate the effects of Scutellaria baicalensis Extract (SBE) on skin lesion of Contact dermatitis (CD) in mice. We investigated the effects of SBE on skin thickness, skin lesions, erythema index and melanin index in vivo. The effects on body weights and spleen/body weight ratio were also investigated in mice with CD induced by topical application of 1-Fluoro-2,4-dinitrofluorobenzene (DNFB). In our results, topical application of SBE lowered skin thickness significantly. In addition, SBE ameliorated skin lesions such as erythema, exudate and petechia in mice with CD. SBE also inhibited erythema index elevated by DNFB significantly. finally, SBE did not affect body weight and spleen/body weight ratio. In conclusion, these data imply that SBE can ameliorate skin lesion of CD such as erythema, exudate and petechia, and be used to treat CD patients with relative safety.
Abstract
Scutellaria baicalensis Georgi is one of major herbs used to treat patients with skin diseases diagnosed by wind-heat syndrome. This study was designed to investigate the effects of Scutellaria baicalensis Extract (SBE) on skin lesion of Contact dermatitis (CD) in mice. We investigated the effects of SBE on skin thickness, skin lesions, erythema index and melanin index in vivo. The effects on body weights and spleen/body weight ratio were also investigated in mice with CD induced by topical application of 1-Fluoro-2,4-dinitrofluorobenzene (DNFB). In our results, topical application of SBE lowered skin thickness significantly. In addition, SBE ameliorated skin lesions such as erythema, exudate and petechia in mice with CD. SBE also inhibited erythema index elevated by DNFB significantly. finally, SBE did not affect body weight and spleen/body weight ratio. In conclusion, these data imply that SBE can ameliorate skin lesion of CD such as erythema, exudate and petechia, and be used to treat CD patients with relative safety.
참고문헌 (19)
- 김은희, "아토피 피부염의 주증상에 대한 문헌적 고찰", 대한한의학원전학회지, 22(1), pp.207~228 (2009), 대한한의학원전학회
- The textbook compilation committee of Korean dermatology, "Dermatology", pp.154~155 (2001), Yeomunsa
- The textbook compilation committee of Korean herbology, "Bonchohak", pp.218~220 (2010), Younglimsa
- Jun JH, "The Effects of Scutellaria baicalensis GEORGI on Allergic contact dermatitis induced by DNCB in Mice", D.J.I.O.M, 7(1), pp.119~133 (1998)
- 박영숙, "황금열수추출물이 DNCB로 유도된 알레르기성 접촉피부염 흰쥐의 항산화능 및 표피회복능에 미치는 영향", 한국식품영양과학회지, 35(6), pp.543~548 (2006), 한국식품영양과학회
- 윤미영, "NC", Nga Mouse 동물모델에서 황금가수분해물이 피부염 병변에 미치는 예방효과, 2015, pp.13(6), 917~925[DOI]
- 윤미영, "황금가수분해물의 아토피 피부염 예방효과", 한국미용학회지, 18(5), pp.1104~1111 (2012), 한국미용학회
- Kim TW, "Topical application of Scutellaria baicalensis suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis", Nat Prod Res, 30(6), pp.705~709 (2016)
- Kim H, "Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice", J Ethnopharmacol, 142(1), pp.253~258 (2012)
- Blauvelt A, "Allergic and immunologic diseases of the skin", J Allergy Clin Immunol, 111(2 Suppl), pp.S560~S570 (2003)
- Dickel H, "Importance of irritant contact dermatitis in occupational skin disease", Am J Clin Dermatol, 3(4), pp.283~289 (2002)
- Nosbaum A, "Allergic and irritant contact dermatitis", Eur J Dermatol, 19(4), pp.325~332 (2009)
- Jung HS, "Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro", J Ethnopharmacol, 141(1), pp.345~349 (2012)
- Jeong HS, "Baicalin-induced Akt activation decreases melanogenesis through downregulation of microphthalmia-associated transcription factor and tyrosinase", Eur J Pharmacol, 761, pp.19~27 (2015)
- Li X, "Baicalein inhibits melanogenesis through activation of the ERK signaling pathway", Int J Mol Med, 25(6), pp.923~927 (2010)
- Ou L, "Oxidation of ferulic acid by Momordica charantia peroxidase and related anti-inflammation activity changes", Biol Pharm Bull, 26(11), pp.1511~1516 (2003)
- Nakao R, "Dosing schedule-dependent attenuation of dexamethasone-induced muscle atrophy in mice", Chronobiol Int, 31(4), pp.506~514 (2014)
- Kim M, "Anti-inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice", Pharmacogn Mag, 10(Suppl 2), pp.S377~S382 (2014)
- Lee HJ, "Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice", Mol Med Rep, 12(2), pp.2135~2139 (2015)