Anti-Allergic Effect of Ulmus davidiana Cortex on Contact Dermatitis Induced by Dinitrofluoro- Benzene in Mice
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Objective: The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we used 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production. Results: URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation,topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum. Conclusion: These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.
Abstract
Objective: The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we used 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production. Results: URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation,topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum. Conclusion: These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.
참고문헌 (16)
- The textbook compilation committee of Korean herbology, "Bonchohak", pp.735~ (2010), Younglimsa
- Lee KH, "Antioxidative activity of Ulmi cortex extract", Korean J Postharvest Sci Technol, 7(4), pp.373~379 (2000)
- Song IK, "Anti-inflammatory effect of Ulmus davidiana Planch (Ulmaceae) on collagen-induced inflammation in rats", Environ Toxicol Pharmacol, 23(1), pp.102~110 (2007)
- 최상윤, "Isolation and Anti-Inflammatory Activity of Bakuchiol from Ulmus davidiana var. japonica", Journal of Medicinal Food, 13(4), pp.1019~1023 (2010), 한국식품영양과학회
- 황성주, "유백피 추출물을 함유한 하이드로갤 패치의 주름 억제 효과", Journal of Pharmaceutical Investigation, 34(3), pp.193~199 (2004), 한국약제학회
- Alase A, "Therapeutic strategies in allergic contact dermatitis", Recent Pat Inflamm Allergy Drug Discov, 6(3), pp.210~221 (2012)
- Dudeck A, "Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens", Immunity, 34(6), pp.973~984 (2011)
- Broide DH., "Molecular and cellular mechanisms of allergic disease", J Allergy Clin Immunol, 108(2 Suppl), pp.S65~S71 (2001)
- Diepgen TL, "Occupational skin diseases", J Dtsch Dermatol Ges, 10(5), pp.297~313 (2012)
- Saint-Mezard P, "Allergic contact dermatitis", Eur J Dermatol, 14(5), pp.284~295 (2004)
- Cohen D, "Treatment of irritant and allergic contact dermatitis", Dermatol Ther, 17(4), pp.334~340 (2004)
- Wen MC, "Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma", J Allergy Clin Immunol, 116(3), pp.517~524 (2005)
- Kim H, "Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice", J Ethnopharmacol, 142(1), pp.253~258 (2012)
- Kim JK, "Effect of Scrophularia buergeriana extract on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice", Inflammation, 35(1), pp.183~191 (2012)
- Jiang S, "Effects of a Dictamnus dasycarpus T. extract on allergic models in mice", Biosci Biotechnol Biochem, 72(3), pp.660~665 (2008)
- Machado-Pinto J, "Eosinophilic and neutrophilic spongiosis: clues to the diagnosis of immunobullous diseases and other inflammatory disorders", Semin Cutan Med Surg, 15(4), pp.308~316 (1996)