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Antidepressant-like Effects of the Gastrodia elata Bl Extract in Mice

조성훈|홍순상
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2013.10|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제24권 제3호|pp. 281-292

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참고문헌

키워드

DepressionAntidepressantForced swim test (FST)Tail suspension test (TST)Gastrodia elata Bl (GE)Glutamate.
주제분류한의학

초록

Objectives :A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). This study was performed to investigate the antidepressant-like effects of the ethanolic extract of Gastrodia elata Bl (GE) in mouse models and to investigate the role of α-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects.Methods :The forced swim test (FST) and tail suspension test (TST) were used to investigate GE's behavioral effects in mice. Additional biochemical and behavioral experiments with NBQX, an AMPA receptor antagonist, were undertaken to determine whether the antidepressant-like properties of GE are involved in AMPA receptor throughput.Results :Oral administration of GE extract (1,600 mg/kg) 1h prior to testing significantly reduced the immobility times in the FST and TST. These antidepressant-like effects of GE extract were increased dose-dependently. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the GE extract in the FST and TST.Conclusions :The ethanolic extract of GE may exert antidepressant-like effects with involvement of AMPA receptor.

Abstract

Objectives :A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). This study was performed to investigate the antidepressant-like effects of the ethanolic extract of Gastrodia elata Bl (GE) in mouse models and to investigate the role of α-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects.Methods :The forced swim test (FST) and tail suspension test (TST) were used to investigate GE's behavioral effects in mice. Additional biochemical and behavioral experiments with NBQX, an AMPA receptor antagonist, were undertaken to determine whether the antidepressant-like properties of GE are involved in AMPA receptor throughput.Results :Oral administration of GE extract (1,600 mg/kg) 1h prior to testing significantly reduced the immobility times in the FST and TST. These antidepressant-like effects of GE extract were increased dose-dependently. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the GE extract in the FST and TST.Conclusions :The ethanolic extract of GE may exert antidepressant-like effects with involvement of AMPA receptor.

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