Carrageenan유발 동통에 대한 전침의 빈도와 시간에 따른 완화 효과
Comparative Studies of the Electroacupuncture with Different Frequency and Duration Time in the Carrageenan-injected Rats
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Abstract
We investigated the comparative effect with different frequency and duration time of electroacupuncture(EA) for suppression of pain. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw. Bilateral EA stimulation with 2 ㎐, 15 ㎐ and 120 ㎐ were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles in carrageenan-injected rats. The paw and tail thermal hyperalgesia were measured in 30-minute intervals after carrageenan injection using hot plate and tail flick analgesia meter, respectively. The significant difference was found between the control and any of EA frequencies examined. Especially 2 ㎐ EA presented more effective inhibitory effects compared with other frequency of EA in tail flick latency. The hyperalgesia induced by carrageenan was strongly inhibited by 2 ㎐ EA from 5 min post and reached sufficient effects from 20 min post EA treatment. These results suggest that EA treatment might be a useful therapy for mitigation of inflammatory pain.
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