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Antifungal Activity of 4-Geranyloxy Compound on the Dermatophytic Fungus

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초록

4-Geranyloxy compound (1) has elucidated by spectroscopic analysis. This compound (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (2 mm inhibition zone at 15 μg/disc), cytotoxic to P388 murine leukaemia cell lines ATCC CCL 46 P388D1, (IC50 1,125 ng/ml at 7.5 μg/disc) and BSC monkey kidney cell lines (100% of well at 15 μg/disc).

Abstract

4-Geranyloxy compound (1) has elucidated by spectroscopic analysis. This compound (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (2 mm inhibition zone at 15 μg/disc), cytotoxic to P388 murine leukaemia cell lines ATCC CCL 46 P388D1, (IC50 1,125 ng/ml at 7.5 μg/disc) and BSC monkey kidney cell lines (100% of well at 15 μg/disc).

참고문헌 (11)

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  3. "University of Otago 1995", University of Otago
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  9. "Synthesis and biological effects of acyclic pyrimidine nucleoside analogues", pp.1078~1083 (1981)
  10. "Screening for biological activity of crude extract and fractions from Brachyglottis monroi", pp.826~828 (2003)
  11. "A method for the rapid partitioning of natural product extracts", pp.290~292 (1987)

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