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Phospholipase A2 藥鍼이 腦虛血을 誘發시킨 흰쥐의 神經傳達物質에 미치는 影響

The Effect of Phospholipase A2 Herbal-acupuncture on Neurotransmitters against Middle Cerebral Artery Occulsion Rats.

정태영|임성철|서정철|한상원|김성민
한의병리학회 (The Society of Pathology in Korean Medicine)|2004.10|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제18권 제5호|pp. 1322-1330

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참고문헌

주제분류한의학

초록

Abstract

This experimental studies were performed in order to prove the effect of Phospholipase A2(PLA2) Herbal-acupuncture by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO). We observed the change of extracellular concentrations(μM) of dopamine, DOPAC, HVA, HIAA, glutamate, aspartate, GABA, glysine, taurine, alanine, and tyrosine as extracted by vivo microdialysis, in the PLA2 Herbal-acupuncture administrated rats(240～260g, Sprague-Dawley) subjected to the MCAO. The dialysates were extracted three times before the MCAO and six times after the MCAO every 20 minutes, and analysed by highperformance liquid chromatography(HPLC). PLA2 Herbal-acupuncture significantly inhibited glutamate and tyrosine which are stimulant neurotransmitters at brain ischemia, and it significantly decreased glycine, GABA, taurine, and alanine which are inhibitory neurotransmitters at brain ischemia. PLA2 Herbal-acupuncture may prevent delayed neuronal death(DND) in selectively vulnerable focal areas of the brain effectively.

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