A new derivative of phorbaketals isolated from a Marine Sponge Phorbas species
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A new sesterterpenoid, phorbaketal derivative, was isolated from the marine sponge Phorbas species. Its planar structures was completely determined from a combination of extensive 1D and 2D NMR experiments and MS data, and also the stereochemistry on the chiral centers were established by the ROESY experiment and the comparison with the ^1H and ^(13)C chemical shifts of the known phorbaketal compounds. This compound 1 moderately showed cytotoxicity effect against hepatoma cancer HepG2 cell.
Abstract
A new sesterterpenoid, phorbaketal derivative, was isolated from the marine sponge Phorbas species. Its planar structures was completely determined from a combination of extensive 1D and 2D NMR experiments and MS data, and also the stereochemistry on the chiral centers were established by the ROESY experiment and the comparison with the ^1H and ^(13)C chemical shifts of the known phorbaketal compounds. This compound 1 moderately showed cytotoxicity effect against hepatoma cancer HepG2 cell.
참고문헌 (11)
- J. W. –H. Li, , Science, 325, pp.161~ (2009)
- J. W. Blunt, , Nat. Prod. Rep, 25(1), pp.C35~ (2008)
- P. A. Searle, , J. Am. Chem. Soc, 117, pp.8126~ (1995)
- D. S. Dalisay, , J. Am. Chem. Soc, 131, pp.7552~ (2009)
- D. Vuong, , J. Nat. Prod, 63, pp.1684~ (2000)
- J.-R. Rho, , Tetrahedron, 58, pp.9285~ (2002)
- K. H. Jang, , J. Nat. Prod, 71, pp.1701~ (2008)
- J. Daoust, , Org. Lett, 12, pp.3208~ (2010)
- D. S. Dalisay, , Org. Lett, 11, pp.1967~ (2009)
- J.-R. Rho, , Org. Lett, 11, pp.5590~ (2009)
- J.-R. Rho, , Org. Lett, 13, pp.884~ (2011)