한약재 물 추출물의 생리활성 검색 및 MPTP-유도 신경독성에 대한 대황의 보호효과
Screening of the Biologoical Activity from Water Extractsof the Medicinal Plants and the Protective Effect of R. palmatum on MTPT-induced Neurotoxicity
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Abstract
This present study was designed to screen medicinal plants for the treatment of brain diseases such as Parkinson's disease or aging. We tested the effects of the water extracts from 38 species medicinal plants on antioxidant capacity, monoamine oxidase B (MAO-B) inhibitory activity, acetylcholinesterase (AChE) inhibition and antiperoxidation activity in vitro. The water extracts from 38 species were tested on their antioxidant activity using radical scavenging effects against ABTS+. The water extract of C. sappan was showed the highest antioxidant capacity, the antioxidant activity at 1㎍ of herbal extract being 0.38 mM TE. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe2+ was strong inhibited by C. sappan and R. palmatum extracts. Among the 38 medicinal plants investigated, R. palmatum showed significant biological activity (antioxidant capacity, MAO-B inhibiory activity, and AChE inhibitory activity). The protective efficacy of R. palmatum water extract on 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism and its possible mechanism were studied in C57BL/6 mice. Treatment of R. palmatum water extract protected biomacromolecules such as lipids from oxidative damage induced by MPTP. The content of MDA in brain tissue was decreased significantly by R. palmatum extract. These results suggest that R. palmatum water extract plays on effective role in attenuating MPTP-induced neurotoxicity in mice. This protective effect of R. palmatum might be estimated the result from the inhibitory activity on monoamine oxidase B and the enhancement of antioxidant activity.
참고문헌 (113)
- "Prevalence of Alzheimer' disease in community population of older persons", pp.2551~262 2556 (1989)
- "National Institute on Aging Progress Report on Alzheimer's disease", pp.~3994 (1995)
- "Diagnosis of Alzheimer's disease", pp.1097~1105 (1985)
- "The prevalence of dementia A quantitative integration of the literature", pp.564~479 (1987)
- "Neuroprotective therapy for Parkinson's disease", pp.24~28 (1997)
- "Role of free radicals and catalytic metal ions in human disease Methods in Enzymology 186", pp.1~85 (1990)
- "Metal ion-catalyzed oxidation of proteins", pp.315~325 (1990)
- "free radical production in neural degeneration", pp.37~63 122 (1994)
- "Oxidative damage to DNA in diabetes mellitus", pp.444~347 445 (1996)
- "Evidence fro neuronal oxidative damage in Alzheimer's disease", ola(w), pp.21~28 (1996)
- "A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish", pp.1780~1783 (1994)
- "Oxidative stress and genetics in the pathogenesis of Parkinsons disease", pp.240~7 250 (2000)
- "Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene", pp.59~63 (1975)
- "health protection branch studies on butylated hydroxyanisole", phe(lic antioxidants), pp.49~54 (1995)
- "Pharmacological treatment of cognitive deficits in Azheimer's disease", pp.324~329 (2001)
- "Cholinesterase in cerebrosponal fluid A longitudinal study in Alzheimer disease", pp.403~407 (1987)
- "A disorder of cortical cholinergic innervation", pp.1184~219 1189 (1983)
- "Acetylcholinesterase in Alzheimer's disease" (1961)
- "Possible causes of Alzheimer's disease", pp.129~5 141 (1998)
- "Cognitive enhancement therapy for Alzheimer's disease", pp.752~53 768 (1997)
- "Acetylcholinesterase inhibition by territrem B derivatives", pp.857~862 (1995)
- "An acetylcholinesterase inhibitor isolated from Corydalis Tuber and its mode of action", pp.91~95 (1996)
- "Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia", pp.170~178 (1997)
- "Inhibition of nitric oxide synthase by 1-", anti(ciceptive and cardiovascular effects), pp.2 423~431 (1996)
- "Monoamine oxidase B in brains from patients with Alzheimer's disease", pp.1~12 (1991)
- "The molecular pharmacology of L-deprenyl", pp.97~108 (1992)
- "Purification and properties of human brain mitochondrial monoamine oxidase", pp.15~39 25 (1970)
- "Qualitative and quantitative evaluation of anthraquinone derivaties in Indian rhubarb", pp.103~108 (1972)
- "Substrate and inhibitor- related characteristics of human platelet monoamine oxidase", pp.853~858 (1977)
- "The monoamine oxidases of brain selective inhibition with drugs and the consequences for the metabolism of the biogenic amines", pp.733~740 (1974)
- "MPTP mechanism of neurotoxicity and their implications for Parkinson's disease", pp.273~286 (1991)
- "Chronic parkinsonism in human due to a product of meperidine analog synthesis", pp.979~219 980 (1983)
- "The neurotoxicity of 1-methyl-4-phenyl-1 6- tetrahydropyridine in the monkey and man", pp.166~168 (1984)
- "Metabolism of the neurotoxic tertiary amine", and castag(li), pp.574~578 (1984)
- "Intraneuronal generation of a pyridinium metabolic may cause drug-induced parkinsonism", pp.464~311 467 (1984)
- "The role of oxidative stress in the systematic toxicity of MPTP and MPP+", pp.571~574 (1986), Academic Press New York
- "MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes"
- "evidence from measures of reactive oxygen species dopamine levels", pp.27~18 34 (1994)
- "Evidence for generation of oxidative stress in brain by MPTP in vitro and in vivo studies in mice", pp.44~52 (1997)
- "Oxidative stress induced by MPTP and MPP+ selective vulnerability of cultured astrocytes", pp.237~244 (1999)
- "The specific vulmerability of the substantia nigra to MPTP is related to the presence of transition metals", pp.25~33 (1985)
- "Effect of MPTP and L-Deprenyl on antioxidants enzymes and lipid peroxidation level in mouse brain", pp.2725~2733 (1995)
- "Rapid ATP loss caused by 1-methyl-4-phenyl-1 6-tetrahydropyridine in mouse brain", pp.348~351 (1991)
- "Inhibition of mitochondrial NADH dehydrogenase by pyridine derivaties and its possible relation to experimental and idophathic Parkinsonism", pp.267~275 (1986)
- "Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridinium a metabolite of the neurotoxine", pp.1 6 2503~2508 (1985)
- "Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ion", pp.294~299 (1987)
- "Selective accumulation of MPP+ in the substantia nigra a key to neurotoxicity", pp.207~212 (1985)
- "6-tetrahydropyridine is neurotoxic to the nigro-striatal dopamine pathway", pp.1 56~319 57 (1986)
- "Resistance of golden hamster to 1-methyl-4-phenyl-1 relationship with low levels of regional monoamine oxidase-B", pp.6~ (1906)
- "Neuroprotective strategies for basal ganglia degeneration Progress in Neurobiology 60", pp.409~470 (2000)
- "Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenyl- 1" (1951)
- "MPTP parkinsonism in humans and animals", pp.137~144 (1987)
- "Oxidation products arising from the action of monoamine oxidase B on 1-methyl-4-benzyl-1 A nonneurotoxic analogue of 1-methyl-4-phenyl-1", pp.6 6 2012~2016 (1994)
- "Apomorphine protects against MPTP-induced neurotoxicity in mice", pp.612~618 (1999)
- "Protection against the dopaminergic neurotoxicity of 1- methyl- 4- phenyl- 1 6 -tetrahydropyridine by monoamine oxidase inhibitor", manzi, pp.467~311 469 (1984)
- "Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1", pp.6 209~210 (1984)
- "Selegiline is neuroprotective in primary brain cultures treated with 1-methyl-4-phenylpyridinium"
- "-deprenyl of 1-methyl-4-phenylpyridinium ion -induced apotosis independent of MAO-B inhibition"
- "The effects of L-deprenyl treatment alone and combined with GM1 ganglioside", pp.226~230 (1998), on striatal dopamine content and substantia nigra pars compacta neurons
- "6-tetrahydropyridine induced ATP loss in the mouse striatum", pp.7 41~48 (1999)
- "multiple roles in the therapy of neurodegenerative disorders", pp.25~47 (2000)
- "The protective of riluzole in the MPTP model of Parkinson's disease in mice is not due to in MPP+ accumulation", pp.1016~1020 (2000)
- "Biological effects of the superoxide radical", pp.1~15 (1986)
- "Historical introduction to free radical and antioxidant biomedical research In CRC handbook of free radical and antioxidants in biomedicine", pp.3~16 (1989), CRC Press
- "Oxidative processes and antioxidative defense mechanism in the aging brain", pp.526~533 (1995)
- "Brief communication azulenyl nitrone spin trap protect against MPTP neurotoxicity", pp.163~166 (1998)
- "Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice", pp.157~164 (1999)
- "Neuroprotection by sodium salicylate against 1-methyl- 4-phenyl-1", pp.6 281~290 (2000)
- "Monoamine oxidase_B inhibitors in treatment Alzheimers disease", pp.343~348 (2000)
- "Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1 6- tetrahydropyridine in C57BL", 6 mice, 167~281 170
- "Elevation of antioxidant potency in the brain of mice by low-dose γ-ray irradiation and its effect on 1-methyl-4-phenyl-1", pp.6 388~395 (1999)
- "Total antioxidant status in plasma and body fluids", pp.279~293 (1994)
- "Serum lipoperoxide levels in patients suffering from liver disease", pp.267~270 (1977)
- "Correlation of 1-methyl-4-phenyl-1 6-tetrahydropyridine neurotoxicity with blood brain barrier monoamine oxidase activity", pp.3521~3525 (1987)
- "Protein measurment with the Folin-phenol reagent", pp.265~275 (1951)
- "Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes", pp.78 473~483 (1985)
- "Age- and peroxidative stress- related modifications of the cerebral enzymatic activities linked to mitochondria and glutathione system", pp.77~101 (1995)
- "Are reative oxygen species involved in Alzheimer's disease", pp.661~16 671 (1995)
- "Relationship of resistance to oxygen free radicals to CuZn-superoxide dismutase activity in trasgenic", pp.903~910
- "Shortcomings of an automated assay for total antioxidant status in biological fluids", pp.1712~1714 (1996)
- "Analytical aspects of antioxidants and free radical activity in clinical biochemistry"
- "Annals of Clinical Biochemistry 35", pp.48~56 (1998)
- "Comparative antioxidant potential of anaethetics and perioperative drugs in vitro Comparison of relative antioxidant activities of British medicinal plant species in vitro", eth(pharmacol), pp.41 47~53 51 (2000), Clinica Chimica Acta 301
- "Hydroxyl radical scavenging activity of flavonoids", pp.2489~2491 (1987)
- "Age- related changes in reactive oxygen species production in rat brain homogenates", pp.175~22 181 (2000)
- "Effective human cancer prevention as goal for the regulation of environmental chemicals", pp.339~351 (1991)
- "The contribution of plant food antioxidants to human health", pp.75~6 82 (1995)
- "Journal of Cereal Science 33", pp.115~129 (2001)
- "三和散이 腦組織의 acetylcholine esterase 및 monoamine oxidase 活性에 미치는 影響", pp.78~92 (1997)
- "七福飮이 노화 백서 뇌조직의 생화학적 변화에 미치는 영향", pp.25~37 (1997)
- "定志丸이 腦組織의 生化學的 變化와 神經細胞의 損傷에 미치는 實驗的 硏究", pp.392~409 (1998)
- "Monoamine oxidase activity and monoamine metabolism in brains of Parkinsonianpatients treated with L-deprenyl", pp.1359~1365 (1986)
- "The concurrent estimation of the major monoamine metabolites in human and non-human primate brain by HPLC with fluorescence and electrochemical detection", pp.499~505 (1981)
- "Quinoline and quinaldine as naturally occurring inhibitors specific for type A monoamine oxidase", pp.1075~1082 (1986)
- "Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases", pp.2307~2310 (1994)
- "Isolation of monoamine oxidase B inhibitory compound from the leaves of Eucommia ulmoides", pp.166~169 (1999)
- "Phenolics with inhibitory activity on mouse brain monoamine oxidase from whole parts of Artemisia vulgaris L", pp.179~182 (2000)
- "Screening of the acetylcholinesterase inhibitors from medicinal plants", pp.167~173 (1997)
- "Kinetic evaluation of MAO-B activity following oral administration of selegiline and desmethyl-selegiline in the rat", pp.131~137 (1990)
- "Pargyline-induced mania in primary affective disorder", pp.25~44 26 (1983)
- "Spontaneaus blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys", pp.214~158 220 (1999)
- "Comparative toxicity of MPTP 3- dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigra", iacofa, pp.3 171~174 (1986)
- "MK-81 fail to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1 6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridium in rats", manzi (1979)
- "Difference in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1 6-tetrahydropyridine in C57", BL and CD-1 mice, 195-2041994, ~126
- "No changes in behavior nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats", pp.583~591 (1996)
- "Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo", pp.351~359 (1998)
- "Mechanism of food restriction Protection of cellular homeostasis", pp.13~15 (1990)
- "MPTP produces differential oxidative stress and antioxidative responses in the nigrostriatal and mesolimbic dopaminergic pathways", pp.76~84 (1998)
- "in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake", and castag(ll), pp.1 65~74 (1989)
- "The neurotoxicity and the relevance to Parkonson's disease", pp.8~13 (1990)
- "Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4- phenyl-1", castag and castag(li li), pp.6 856~864 (1999)
- "In advances in neurology", pp.499~510 (1979), Ravan Press
- "In Treatment of Depression", pp.237~252 (1983), Raven Press
