紫河車 약침이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
Effect of Hominis Placenta Herbal Acupuncture on immune cells and cytokines in OVA-induced asthmatic mice
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Abstract
This experiment was designed to investigate the effect of Mominis Placenta herbal acupuncture solution(HP-HAS) on immune cells and cytokines in murine asthma model. In vivo C57BL/6 mice were sensitized and challenged with OVA for 12 weeks. The experimental group was treated with Hominis Placenta herbal acupuncture solution(HP-HAS) at P'yesu(BL13) for the later 8 weeks(3 times a week) and analyzed by ELISA, flow cytometer. The results were obtained as follows Eosinophils in BALF(bronchoalveolar lavage fluid) of HP-HAS group decreased significantly compared with that of control group. IL-4, IL-5, IL-13, IgE in BALF of HP-HAS group decreased significantly compared with that of control group. Number of CD3e-/CCR3+, CD69+/CD3e+, CD11b+/Gr-1+ cells in the HP-HAS group decreased compared with that of control group.
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