황금이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
Effect of Scutellaria Radix extract drug on immune cells and cytokines in BALF of OVA-induced asthmatic mice
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Abstract
objective : The purpose of this research is to examine the effects of Scutellaria Radix(SR) extract on immune cells and cytokines in ovalbumin(OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 9 weeks. In this experiment, one group was not treated, and the other group was treated with SR extract for six weeks(five times per week) and analyzed by ELISA and flow cytometer. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-13 in BALF (bronchoalveolar lavage fluid) compared with that of control group. However, IFN-γ in the SR group increased significantly compared with that of control group. Additionally, the population of CD3e-/CCR3+, CD69+/CD3e+, IgE+/B220+, CD11b+/Gr-1+ cells in the SR group decreased compared with that of control group. conclusion : The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing INF-γ, Which helps prevent such reactions.
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