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Water-Soluble Fraction of Rheum Undulatum Attenuates Amyloid-β-induced Neuronal Death and Microglial Activation in Vitro

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Abstract

Oxidative stressand glia-associated chronic inflammation have been linked to the pathophysiology of Alzheimer's disease. Rhei rhizoma has been commonly used as a purgative and a haemostatic agent in traditional oriental medicine. Recently, the methanol extract from a dried root of Rheum undulatumhas been shown to have anti-allergic and anti-inflammatory effects. In this study, we tested the potential of the extract of Rheum undulatum for neuroprotective agent. The aqueous extract of Rheum undulatum reduced cell death and p53 phosphorylation in neuronal cells and attenuated levels of cyclooxygenase-2 and inducible nitric oxide synthase mRNAs in BV2 microglial cells treated with amyloid-β

참고문헌 (18)

  1. "A.Mechanisms of neuronal degeneration in Alzheimer's disease", 16, pp.921~932 (1996)
  2. "Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity", 4, pp.827~831 (1998)
  3. "J.Microglia and Alzheimer's disease pathogenesis", 77, pp.1~8 (2004)
  4. "Study onanti-Oketsu activity of Rhubarb II Anti-allergic effects of stilbene components from Rhei undulati Rhizoma dried rhizome of Rheum undulatum cultivated in Korea", 24, pp.264~267 (2001)
  5. "Effects of stilbene constituents from Rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages", 10, pp.323~327 (2000)
  6. "N'-tetraacetic acid induces caspase-mediated apoptosis and reactive oxygen species-mediated necrosis in cultured cortical neurons", 78, pp.2 230~239 (2001)
  7. "Immortalization of murine microglial cells by a v-raf", v-myc carrying retrovirus, 1990, pp.j neuroimmu(l 27), 229~237
  8. "the cellular gatekeeper for growth and division", 88, pp.323~331 (1997)
  9. "DNA damage-induced phosporylation of p53 alleviates inhibition by MDM2", 91, pp.325~334 (1997)
  10. "Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage", 17, pp.2746~2755 (1997)
  11. "Mediation of inflammation by cyclooxygenase-2", 46, pp.46 41~50 (1995)
  12. "Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain", 87, pp.319~324 (1998)
  13. "Nitric oxide-mediated neuronal injury in multiple sclerosis", pp.143~146 (1992)
  14. "Oxygen free radicals and neurodegeneration in Parkinson's disease a role for nitric oxide", pp.64~68 (1994)
  15. "In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes", 6, pp.1053~1057 (1995)
  16. "Amyloid in Alzheimer's disease and prion-related encephalopathies studies with synthetic peptides", 49, pp.287~315 (1996)
  17. "Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum", 22, pp.401~403 (1999)
  18. "Antioxidant constituents from Rhubarb Structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides", 9, pp.41~50 (2001)

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