Effect of the Geijibokryunghwan Water Extracts on Stimulus-induced Superoxide Generation and Tyrosyl Phosphorylation in Human Neutrophils
0
조회
0
다운로드
2
인용
0
참고문헌
초록
Abstract
A clinical report indicates that `Geijibokryunghwan(GBH) is very effective in treating thrombosis in those patients who have difficulties with more conventional antithrombotic drugs. The isolation and identification of various compounds from this plant and the same genus have been reported by several groups. However, the pharmaceutical effect of the GBH on superoxide generation in human neutrophils has not been studied. In the present report, we investigated the possibility of using herbal medicine as an alternative therapy. In particular, we studied tremor in antiatheroscleosis. In this report, we shows the GBH extract can be used as a potential atherosclerosis preventive agent in human. The effect of GBH on stimulus-induced superoxide generation and phosphorylation of tyrosine residues of protein in human neutrophils was investigated. In a conclusion, GBH suppressed tyrosine phosphorylase in a dose-dependent manner, and may have pharmacoceutical applications. These data suggest that GBH extracts merits investigation as a potential anti-atherosclerogenic agent in humans.
참고문헌 (18)
- Kim, J.G.,, "An experimental study on the effect of Geijibokryunghwan Dangguijakyaksan and each constituent herb on inhibition of platelet aggregation of the Korea Institute of Oriental Medical Diagnostics 4", pp.71~84 (2000)
- Sugiyama, K.,, "The Japanese herbal medicine 'saiko-keishi-to' activates GABAA receptors of rat sensory neurons in culture", pp.147~150 (1996)
- Ishikawa, T.,, "Effectiveness of the Kampo kami-shoyo-san for tremor of antipsychotic-induced parkinsonism", pp.579~24 684 (2000)
- Jiangsu Medical College, "Encyclopedia of Chinese Materia Medica" (1977), Shanghai Science and Technology Press 1300
- Goldstein, "Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis", pp.1155~1163 (1975)
- Rossi, "The O2-forming NADPH oxidase of the phagocytes mechanisms of activation and function", pp.65~853 89 (1986)
- Takahashi, "Luminol chemiluminescence and active oxygen generation by activated neutrophils", pp.325~330 (1991)
- McColl, "Involvement of tyrosine kinase in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor" (1991)
- Watanabe, "Iminodipeptides containing proline with C-terminal and N-terminal residues prime the stimulation of human neutrophil superoxide generation by fMLP", pp.758~764 (1994)
- Zhang, J.,, "Effect of cystathionine ketimine on the stimulus coupled responses of neutrophils and their modulation by various protein kinase inhibitors", pp.371~376 (1996)
- Kodama, H.,, "Novel priming compounds of cystathionine metabolites on superoxide generation in human neutrophils", pp.297~301 (2000)
- Lee, S.K, "Effect of the Geijibokryunghwan on human hepatocarcinoma cells A thesis of degree of master" (2001), Dongguk Univ
- Kim, J.G.,, "An experimental study on the effect of Geijibokryunghwan Dangguijakyaksan and each constituent herb on inhibition of platelet aggregation of the Korea institute of oriental medical diagnostics", pp.71~84 (2000)
- Weiss, "Chlorination of taurine by human neutrophils Evidence for hypochlorous acid generation", pp.598~607 (1982)
- Yamamoto, "Isolation of salivary polymorphonuclear leukocytes and their stimulation-coupled responses", pp.76~82 (1992)
- Zhang, J, "Effect of cystathionine and cystathionine metabolites on the phosphorylation of tyrosine residues in human neutrophils", pp.849~854 (1996)
- Laemmli, "K.Cleavage of structural proteins during the assembly of the head of bacteriophage", 227, pp.680~685 (1970)
- Laemmli, "K.Cleavage of structural proteins during the assembly of the head of bacteriophage", 227, pp.680~685 (1970)