SD 랫트를 이용하여 四物湯의 아급성 독성에 관한 연구
Subacute Toxicity Study on Samul-tang in SD Rats
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Samul-tang(Siwu-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Samul-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Samul-tang(Siwu-tang) on SD rats. Twenty rats were orally adiministered Samul-tang for 28 days at a dose of 0 ㎎/kg(control group) or 1500 ㎎/kg(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (1500 ㎎/kg) for 28 days. This result suggests that Samul-tang(Siwu-tang), a herbal medicine prescription, is a safe prescription to body.
Abstract
Samul-tang(Siwu-tang) has been traditionally prescribed as a restorative. The present study was undertaken to determine the possible toxic effects of Samul-tang on SD rats. In this study, we investigated the subacute toxicity of water-extracted Samul-tang(Siwu-tang) on SD rats. Twenty rats were orally adiministered Samul-tang for 28 days at a dose of 0 ㎎/kg(control group) or 1500 ㎎/kg(treated group), respectively. All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Compared with the control group, we could not find any subacute toxic alteration in treated group (1500 ㎎/kg) for 28 days. This result suggests that Samul-tang(Siwu-tang), a herbal medicine prescription, is a safe prescription to body.
참고문헌 (14)
- 조무상, "사물탕의 계절별 배미, 가미가 체중변화 및 면역기능에 미치는 실험적 연구", 동서의학, 4, pp.41~66 (1990)
- 김성훈, "사군자탕, 사물탕 및 팔물탕이 prednisolone으로 유발된 생쥐의 면역반응저하에 미치는 영향", 대한동의병리학회지, 1, pp.42~59 (1978)
- 김길수, "월국환합 사물탕이 전기자극 스트레스를 받는 Mouse의 면역기능에 미치는 영향", 석사, pp.2000
- 장세환, "가미사물탕이 당뇨에 미치는 영향에 관한 실험적 연구", 박사, pp.1990
- 김기옥, "사물탕과 사물탕가지모황백이 난소적출 흰쥐의 17β-Estradiol, 골대사 지표 및 뇌위축에 미치는 영향", 박사, pp.2002
- 김양호, "사군자탕, 사물탕 및 팔물탕이 백서 자궁근의 수축력과 자발운동에 미치는 영향", 석사, pp.1992
- 김도환, "Nitric Oxide에 의해 유발된 C6 glial 세포독성에 대한 사물탕의 방어효과", 석사, pp.2000
- 김도순, "육미지황탕, 사물탕, 사군자탕의 항stress 효과에 관한 실험적 비교 연구", 박, pp.1995
- 배종국, "사군자탕과 사물탕 Extract 투여가 rat의 성장에 미치는 영향", 석사, pp.1978
- Hayes, A.W., "Principles and Methods of Toxicology", pp.17~19 (1984), Raven press
- 이경구, "四君子湯, 四物湯, 八物湯 및 十全大補湯의 처방 구성 및 용량 용법에 관한 연구", 대한한의학원전학회지, 19(4), pp.219~225 (2006), 대한한의학원전학회
- 강진석, "독성병리학 도감", pp.80~81 (2001)
- Ewell, M.R., "Have you seen this, Inflammatory lesions in the lungs of rats", Toxicology and Pathology, 125(5), pp.529~531 (1997)
- Slaoui M., "Inflammatory lesions in the lungs of wistar rats", Toxicology and Pathology, 26(5), pp.712~713 (1998)