본문 바로가기
KERD
논문KCI 등재

소지환가미방이 고지혈 병리인자 및 동물 병태 모델에 미치는 영향

Effects of Sojihwangamibang on Hyperlipidemia in Rats Induced by High Cholesterol Diet

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류한의학

초록

This experimental study was designed to investigate the inhibitory effects of Sojihwangamibang on hyperlipidemia in rats induced by high cholesterol diet diet. Sprague- Dawley rats were divided into normal group, control group, SJB treated group. Obese rats were induced by high cholesterol diet treatment for 6 weeks including a oral administration of SJB for 4 weeks. In SJB group, serum total cholesterol, LDL cholesterol, triglyceride and glucose were significantly decreased, and HDL cholesterol was significantly increased compared with untreated control group. In SJB group, HMG-CoA and ACAT concentration of hepatic homogenate were significantly decreased compared with untreated control group. These results provide experimental evidence that SJB, applied currently in the clinical practice, appears to be effective for down-regulating risk factors of hyperlipidemia, and thus may be used as an objective information for the development of therapeutic agents.

Abstract

This experimental study was designed to investigate the inhibitory effects of Sojihwangamibang on hyperlipidemia in rats induced by high cholesterol diet diet. Sprague- Dawley rats were divided into normal group, control group, SJB treated group. Obese rats were induced by high cholesterol diet treatment for 6 weeks including a oral administration of SJB for 4 weeks. In SJB group, serum total cholesterol, LDL cholesterol, triglyceride and glucose were significantly decreased, and HDL cholesterol was significantly increased compared with untreated control group. In SJB group, HMG-CoA and ACAT concentration of hepatic homogenate were significantly decreased compared with untreated control group. These results provide experimental evidence that SJB, applied currently in the clinical practice, appears to be effective for down-regulating risk factors of hyperlipidemia, and thus may be used as an objective information for the development of therapeutic agents.

참고문헌 (42)

  1. 통계청, "2008 한국의 사회지표. 2009년 2월", ~ (2009)
  2. Chun, S., "The risk groups for coronary heart disease in Koreans. Assessment by distribution of serum lipid concentrations", Clin Chem Lab Med, 37, pp.969~974 (1999)
  3. Kim, J.Q., "National cholesterol treatment guidelines in Korean population - setting-up the cutpoints for high blood cholesterol", J Korean Med Sci., 12, pp.17~22 (1997)
  4. National Cholesterol Education Program National Heart, Lung, and Blood Institute National Institutes of Health. Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), , ~, pp.NIH Publication No. 01-3670 (2001)
  5. Grundy, S.M., "Approach to lipoprotein management in 2001 national cholesterol guidelines", Am J Cardiol, 90, pp.11i~21i (2002)
  6. Fedder, D.O., "New national cholesterol education program III guidelines for primary prevention lipid-lowering drug therapy", Circulation, 105, pp.152~156 (2002)
  7. Chuang, P., "Ezetimibe reduces low-density lipoprotein cholesterol (LDL-C) in renal transplant patients resistant to HMG-CoA reductase inhibitors", Am J Ther., 14(5), pp.438~441 (2007)
  8. Adameová, A., "The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats", Pharmazie, 60(9), pp.714~715 (2005)
  9. Westerterp, M., "Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL", J Lipid Res., 247(6), pp.1203~1211 (2006)
  10. Uhita, K., "Drug Use Evaluation of Antidyslipidemic Agents at a Community Hospital in Japan", PSJ, 122(7), pp.499~506 (2002)
  11. Sato, N., "In vivo and in vitro sevoflurane-induced lipid peroxidation in guinea-pig liver microsomes", 75(6), pp.366~370 (1994)
  12. Yang, C.C., "Cardiovascular diseases and the risk of venous thromboembolism: a hospital-based case-control sardy", J Chin Med Assoc., 70(3), pp.103~109 (2007)
  13. Kannel, W.B,, "High-density lipoproteins: epidemiologic profile and risks of coronary artery disease", Am J Cardiol,, 52(4), pp.9B~12B (1983)
  14. Shipley, M.J., "Does plasma cholesterol concentration predict mortality from coronary heart disease in elderly people? 18 year follow up in Whitehall study", BMJ, 303(6794), pp.89~92 (1991)
  15. Miura, S., "Therapies for raising high-density lipoprotein cholesterol", Intern Med., 46(7), pp.339~340 (2007)
  16. Schoenhagen, P., "Determinants of arterial wall remodeling during lipid- lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial", Circulation, 113(24), pp.2826~2834 (2006)
  17. 良石, "秘方大全(名醫珍藏)" (2006), 北京科學技術出版社
  18. Slowing, K., "Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats", J Nutr, 131(3s), pp.994S~999S (2001)
  19. Siegel-Axel, D., "Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis", Cardiovasc Res, 78(1), pp.8~17 (2008)
  20. Igarashi, K., "Improvement of endothelium-dependent coronary vasodilation after a single LDL apheresis in patients with hypercholesterolemia", J Clin Apher., 19(1), pp.11~16 (2004)
  21. Tang, F.T., "Crocetin improves endothelium- dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity", Biochem Pharmacol, 72(5), pp.558~565 (2006)
  22. 横山, "冠動脈疾患과 酸化스트레스", pp.131~138 (2003), 炎症
  23. 小崎丈太郎, "小山千穂:特集 高脂血症治療の曲がり角 Nikkei Medical 6月号", 60~69 (1997)
  24. Fruchart, J.C., "Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism", Drugs Today, 42(1), pp.39~64 (2006)
  25. Shrestha, S., "A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals", J Nutr, 136(10), pp.2492~2497 (2006)
  26. Frick, M.H., "Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease", N Engl J Med., 317(20), pp.1237~1245 (1987)
  27. Tsutsumi, K., "Effects of NO-1886, a lipoprotein lipase promoting agent, on homozygous and heterozygous Watanabe heritable hyperlipidaemic rabbits", Arzneimittelforschung, 50(2), pp.118~121 (2000)
  28. Jukema, J.W., "Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderat- ely elevated serum cholesterol levels. in: The Regression Growth Evaluation Statin Study (REGRESS)", Circulation, 91(10), pp.2528~2540 (1995)
  29. Sacks, F.M., "The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. in: Cholesterol and Recurrent Events Trial investigators", N Engl J Med., 335(14), pp.1001~1009 (1996)
  30. Paoletti, R., "Rosuvastatin is superior to pravastatin and simvastatin in reducing low-density lipoprotein cholesterol, enabling more hypercholesterolemic patients to achieve low-density lipoprotein cholesterol targets" (2001), Am Coll Cardiol Annual Scientific Session
  31. 정은아, "가미과루해백황금탕의 항고지혈증 효과", 응용약물학회지, 9, pp.104~111 (2001)
  32. Kjorholt, C., "Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db", db mouse model of diabetes, 2005, pp.54(9), 2755~2763
  33. Halliwell, B., "Biochemical mechanism accounting for the toxic action of oxygen on living organisms. the key role of superoxide dismutase", Cell. Biol. Int. Rep., 2, pp.11~ (1978)
  34. Susan, M.D., "Normobaric oxygen toxicity of the lung", New. Engl. J. Med., 303, pp.76~ (1980)
  35. Freman, B.A., "Biology of disease : Free radicals and tissue injury", Lab. Invest., 47, pp.412~ (1982)
  36. Vaziri, N.D., "Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome", Kidney Int., 61(5), pp.1769~1775 (2002)
  37. Vaziri, N.D., "ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure", Am J Physiol Renal Physiol, 287(5), pp.F1038~F1043 (2004)
  38. Zoltowska, M., "Bile duct cells: a novel in vitro model for the study of lipid metabolism and bile acid production", Am J Physiol., 276, pp.G407~G414 (1999)
  39. Liang, K., "HMG-CoA reductase inhibition reverses LCAT and LDL receptor deficiencies and improves HDL in rats with chronic renal failure", Am J Physiol Renal Physiol, 288(3), pp.F539~F544 (2005)
  40. Roberts, C.K., "HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X", X.Kidney Int., 66(4), pp.1503~1511 (2004)
  41. Bocan, T.M., "The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression", Atherosclerosis, 157(1), pp.97~105 (2001)
  42. Lee, M.K., "Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats", Bioorg Med Chem, 11(3), pp.393~398 (2003)

관련 논문AI추천

이 간행물의 다른 논문 (23건)