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加味地黃湯이 高脂血症 關聯 因子에 미치는 영향

The Effects of Gamijihwang-tang(GJT) on Hyperlipidemia in Rats

조현경|유호룡|안정조|김윤식|설인찬|박소애
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2009.06|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제30권 제2호|pp. 338-354

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키워드

CholesterolHyperlipidemiaGamijihwang-tang(GJT)SHR
주제분류한의학

초록

Objective : Gamijihwang-tang(GJT) has been used as a therapeutic agent for hyperlipidemia in oriental medicine for several years. This study was performed to investigate the effects of GJT on hyperlipidemia in rats using diverse biological methods. Method : Hyperlipidemia was induced by a hyper-lipidemic diet fed for 4 weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, and glucose were measured in the serum after an oral administration of GJT. Lipid peroxidase, SOD, catalase, ACAT, and HMG-CoA were measured in liver after oral administration of GJT. Result : 1. GJT showed safety against cytotoxicity and toxicity in liver. 2. GJT significantly decreased rat's body and liver weight. 3. GJT significantly decreased serum total cholesterol and LDL-cholesterol, but increased serum HDL-cholesterol. 4. GJT significantly decreased serum triglyceride and glucose. 5. GJT significantly decreased lipid peroxidation and increased SOD and catalase in liver. 6. GJT significantly decreased ACAT and HMG-CoA reductase of cholesterol manifestation in liver. Conclusions : These results suggest that GJT might be effective in treatment and prevention of hyperlipidemia.

Abstract

Objective : Gamijihwang-tang(GJT) has been used as a therapeutic agent for hyperlipidemia in oriental medicine for several years. This study was performed to investigate the effects of GJT on hyperlipidemia in rats using diverse biological methods. Method : Hyperlipidemia was induced by a hyper-lipidemic diet fed for 4 weeks. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, and glucose were measured in the serum after an oral administration of GJT. Lipid peroxidase, SOD, catalase, ACAT, and HMG-CoA were measured in liver after oral administration of GJT. Result : 1. GJT showed safety against cytotoxicity and toxicity in liver. 2. GJT significantly decreased rat's body and liver weight. 3. GJT significantly decreased serum total cholesterol and LDL-cholesterol, but increased serum HDL-cholesterol. 4. GJT significantly decreased serum triglyceride and glucose. 5. GJT significantly decreased lipid peroxidation and increased SOD and catalase in liver. 6. GJT significantly decreased ACAT and HMG-CoA reductase of cholesterol manifestation in liver. Conclusions : These results suggest that GJT might be effective in treatment and prevention of hyperlipidemia.

참고문헌 (44)

  1. 국립국어원, "표준국어대사전. 초판" (1999), 두산동아
  2. 전국한의과대학심계내과학교실, "심계내과학. 초판", pp.169~173 (2006), 군자출판사
  3. 방혜정, "고지혈증에 대한 한의학적 고찰", 동서의학, 20, pp.25~36 (1995)
  4. 함인혜, "茵蔯蒿와 韓茵蔯이 Triton WR-1339로 유도된 고지혈증 흰쥐에 미치는 영향", 대한본초학회지, 20(1), pp.45~52 (2005), 대한본초학회
  5. 최호영, "국산과 중국산 枳實의 Triton WR-1339 유발 高脂血症 흰쥐에 대한 효능 연구", 대한본초학회지, 22(3), pp.109~116 (2007), 대한본초학회
  6. 최호영, "국산 및 중국산 白首烏의 Triton WR-1339 유발 高脂血症 흰쥐에 대한 효능 연구", 대한본초학회지, 22(4), pp.279~286 (2007), 대한본초학회
  7. 1:김형철, 2:조수인, "丹蔘이 고지혈증 흰쥐의 혈중 지질 변화에 미치는 영향", 대한본초학회지, 22(4), pp.239~245 (2007), 대한본초학회
  8. 이장천, "加味防風通聖散이 고지방식이 급여 흰쥐의 체지질구성과 항산화능에 미치는 영향", 대한본초학회지, 20(2), pp.69~75 (2005), 대한본초학회
  9. 박종광, "가미제습순기탕이 고지혈증을 유발시킨 고혈압백서에서의 혈액학적 변화에 미치는 영향", 대전대학교 한의학연구소 논문집, 15(1), pp.19~31 (2006)
  10. 김정수, "시령탕이 고혈압 및 고지혈증에 미치는 영향", 대전대 한의학연구소 논문집, 5(2), pp.319~332 (2005)
  11. 申卿熙, "蒼濟證方. 초판", pp.104~ (1990), 三藏苑
  12. Sato N, "In vivo and in vitro sevoflurane-induced lipid peroxidation in guinea -pig liver microsomes", 75(6), pp.366~370 (1994)
  13. Oyanagui Y, "Reevaluation of assay methods and establishment of kit for superoxide dismutase activity", Anal Biochem, 142(2), pp.290~296 (1984)
  14. Aebi H, "Catalase in vitro", Methods Enzymol, 105, pp.121~126 (1984)
  15. Daniel J, "Principles of Internal medicine. Section 3 Disorders of Intermediary Metabolism. 16th edition", pp.2038~2040 (2006), MIP
  16. 이귀녕, "임상병리파일. 3판", pp.148~199 (2003), 의학문화사
  17. "Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the third report of National cholesterol education Program(NECP) expert panel on detection, evalution, and treatment of high blood cholesterol in adults(Adult Treatment Panel III)", JAMA, 285, pp.2486~2497 (2001)
  18. 김영석, "心腦通, 降脂延壽丹 및 淸心調氣湯의 高脂血症에 대한 實驗的 硏究", 대한한방내과학회지, 19(1), pp.202~218 (1998)
  19. 김병철, "단삼음이 고지혈증에 미치는 영향", 대한한방내과학회지, 21(1), pp.126~134 (2000)
  20. 강윤호, "고지혈증의 치방에 대한 문헌적 고찰", 동서의학, 21(2), pp.70~81 (1996)
  21. 신재용, "방약합편해설", pp.44~47 (2000), 전통의학연구소
  22. 이정호, "천남성이 고지방식이로 유발된 비만 흰쥐의 당지질대사 및 조직화학적 변화에 미치는 효과", 대한한의학회지, 28(1), pp.211~223 (2007), 대한한의학회
  23. 全國韓醫科大學本草學敎授 公編著, "本草學", pp.121~123 (2000), 永林社
  24. 신흥묵, "희첨의 혈관이완 효능과 항산화 동태에 관한 연구", 대한한의학회지, 41(3), pp.77~83 (2000)
  25. 차배천, "계혈등의 항산화 활성", 생약학회지, 36(1), pp.50~55 (2005), 한국생약학회
  26. Kumai T, "Biochemical and morphological characterization of spontaneously hypertensive hyperlipidaemic rats", Clin Exp Pharmacol Physiol, 30(8), pp.537~544 (2003)
  27. 한기훈, "Cardiovascular Update. 초판", 10(4), pp.32~46 (2008)
  28. "Relation of the number of metabolic syndrome risk factors with all cause and cardiovascular mortality", Am J Cardiol, 102(6), pp.689~692 (2008)
  29. 고성경, "BMI와 %Fat에 의한 비만도 평가가 고지혈중 진단에 미치는 영향", 운동과학, 14(1), pp.21~30 (2005), 한국운동생리학회
  30. 윤영숙, "여성의 비만. Background of epidermiology", 대한비만학회지, 13(1), pp.211~224 (2004)
  31. 장명래, "비만도와 비만유형에 따른 혈압, 혈당 및 혈청지질 및 지단백과의 관계", 가정의학회지, 15(12), pp.1076~1087 (1994)
  32. Berk PD, "Regulatable fatty acid transport mechanism are central to the pathophysiology of obesity, fatty liver, and metabolic syndrom", Hepatology, 48(5), pp.1362~1376 (2008)
  33. Halliwell B, "Biochemiacal mechanism accounting for the toxic action of oxygen on living organism. The key role of superoxide dismutase", Cell. Biol. Int. Rep, pp.2~ (1978)
  34. Freman, BA, "Biology of disease: Free radicals and tissue injury", Lab. Invest, 47, pp.412~ (1982)
  35. 대한가정의학회, "가정의학 임상편. 초판", pp.303~309 (2002), 계축문화사
  36. 윤건호, "고지혈증 치료의 최신지견", 가정의학회지, 21(5), pp.31~36 (2000)
  37. Junyent M, "Influence of HDL cholestrol on Preclinical Carotid Atherosclerosis in Familial Hypercholesterolemia", Arterioscler Thromb Vasc Biol, 26(5), pp.1107~1113 (2006)
  38. Arafa HM, "Curcumin attenuates diet-induced hypercholesterolemia in rats", Med Sci Monit, 11(7), pp.228~234 (2005)
  39. Plant S, "Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins", Diab Vasc Dis Res, 5(2), pp.102~108 (2008)
  40. Mehmet Yalniz, I, "Amelioration of Steatohepatitis with Pentoxifylline in a Novel Nonalcoholic Steatohepatitis Model Induced by High-Fat Diet", Dig Dis Sci, 52, pp.2380~2386 (2007)
  41. Milagro FI, "Weight gain induced by high-fat feeding involves increased liver oxidative stress.", Obesity(Silver Spring), 14(7), pp.1118~1123 (2006)
  42. Meachler P, "Role of the intestinal Acyl-CoA: cholesterol acyltransferase activity in the hyper-response of diabetic rats to cholesterol", J. Lipid Res, 33, pp.1475~1484 (1992)
  43. Gills PJ, "Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis implications for drug discovery", Atherosclerosis, 83, pp.177~185 (1990)
  44. Paaladinesh Thavendiranathan P, "Primary prevention of cardiovascular diseases with statin theraphy. A meta-analysis of randomized controlled trials", Arch Intern Med, 166, pp.230~ (2006)

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