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甘松香 물추출물이 U937 백혈병 세포의 분화유도에 미치는 영향

Effect of Nardostachys chinensis on Induction of Differentiation in U937 Monomyelocytic Cells

전병훈|주성민|양현모|김진국|전병제
한의병리학회 (The Society of Pathology in Korean Medicine)|2011.02|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제25권 제1호|pp. 29-36

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참고문헌

키워드

DifferentiationERKPKCNardostachyts chinensis (N. chinensis)U937
주제분류한의학

초록

Nardostachyts chinensis (N. chinensis) belonging to the family Valerianaceae has been used to elicit stomachic and sedative effects. The MAPKs are serine/threonine kinases involved in the regulation of various cellular responses, such as cell proliferation, differentiation and apoptosis. The PKC also plays a key role in regulating the response of hematopoietic cells to both physiological and pathological inducers of proliferation and differentiation. This study investigated the signaling pathways on the U937 cell differentiation induced by N. chinensis. N. chinensis induced the differentiation of U937 cells, as shown by increased of differentiation surface antigen CD11b. Activation of ERK increased time-dependently in differentiation of U937 cells induced by N. chinensis, but activations of JNK and p38 were unaffected. Inhibitor of ERK (PD98059) significantly reduced CD11b expression induced by N. chinensis in U937 cells. In addition, N. chinensis increased protein level of PKC βI and PKC βII isoforms, but the protein level of PKC α and PKC γwas constant. PKC inhibitors (GF 109203X and H-7) inhibited U937 cell differentiation and the ERK activation induced by N. chinensis. These results indicated that PKC and ERK may be involved in U937 cell differentiation induced by N. chinensis.

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