필발 추출물의 포도당 흡수능에 대한 효과
Effects of Fructus Piperis Longi Extracts on Glucose Uptake in Adipocyte
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Glucose uptake plays a pivotal role in maintaining whole body glucose homeostasis in adipocytes and skeletal muscles. In the present study we have shown that Fructus Piperis Longi Extracts (FPLE) can stimulate glucose uptake in OP9 adipocytes. The increasing effects of FPLE on glucose uptake were inhibited by compound C pretreatment, which means that the glucose uptake effects by FPLE were carried out by AMP-activated protein kinase (AMPK) activation. Further studies revealed that FPLE stimulated glucose transport occurs through a mechanism involving extracellular signal-regulated kinase (ERK1/2) activation.
Abstract
Glucose uptake plays a pivotal role in maintaining whole body glucose homeostasis in adipocytes and skeletal muscles. In the present study we have shown that Fructus Piperis Longi Extracts (FPLE) can stimulate glucose uptake in OP9 adipocytes. The increasing effects of FPLE on glucose uptake were inhibited by compound C pretreatment, which means that the glucose uptake effects by FPLE were carried out by AMP-activated protein kinase (AMPK) activation. Further studies revealed that FPLE stimulated glucose transport occurs through a mechanism involving extracellular signal-regulated kinase (ERK1/2) activation.
참고문헌 (15)
- 신민교, "남산당", pp.316~317 (1986), 남산당
- 이영철, "OVA로 유도된 천식 모델 생쥐에 대한 필발의 폐포내 호산구 침윤 및 증식 억제효과", 대한본초학회지, 19(4), pp.17~26 (2004), 대한본초학회
- 이영철, "OVA로 유도된 천식 모델 생쥐에서 필발의 Th1", Th2 cytokines 생성 및 유전자 발현에 미치는 영향, 2005, pp.20(1), 1~8[DOI]
- 이영철, "천식 모델 생쥐에서 필발이 CD25+T 세포수, IgE, Histamine 생성량과 in vitro에서 Th1", Th2 Cytokine Balance에 미치는 영향, 2009, pp.24(1), 79~88[DOI]
- James, D.E., "Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein", Nature, 333, pp.183~185 (1988)
- Cushman, S.W., "Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane", J Biol Chem, 255, pp.4758~4762 (1980)
- Marette, A., "Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle", Am J Physiol, 263, pp.C443~C452
- Fujii, N., "AMP-activated protein kinase and the regulation of glucose transport", Am J Physiol Endocrinol Metab, 291, pp.E867~E877 (2006)
- Wolins, N.E,., "OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis", Journal of Lipid Research, 47, pp.450~460 (2006)
- Abdin, A.A., "Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers", J Diabetes Complications, 24, pp.168~178 (2010)
- Hayden, M.R., "Treating hypertension while protecting the vulnerable islet in the cardiometabolic syndrome", J Am Soc Hypertens, 2, pp.239~266 (2008)
- Fukushima, T., "Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin", insulin-like growth factor-I receptor tyrosine kinases, 2011, pp.404, 767~773
- Zhu, Y., "Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation", Mol Endocrinol, 27, pp.172~184 (2013)
- Kramer, H.F., "Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle", Diabetes, 55, pp.2067~2076 (2006)
- Chen, H.C., "Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport", J Biol Chem, 277, pp.23554~23562 (2002)