고지방식이에 의한 비만 동물모델에서 유산균 마분말의 항비만 효과
Anti-Obesity Effects of Lactic Acid Bacteria-Fermented Dioscoreae Rhizoma Powder on High Fat Diet-Fed Animal Model
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초록
The purpose of this study was to examine the antiobesity effects of lactic acid bacteria-fermented Dioscoreae Rhizoma powder (LDR) in Sprague-Dawley rats with high-fat diet (HFD)-induced obesity. Rats were divided into 5 groups: normal diet group, control (high fat diet-vehicle) group, 0.4 g/kg LDR (high fat diet + 0.4 g/kg lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 1 g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 2.5g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group. Our results indicate that LDR administration has effects on decreasing of body weight, fat weight, blood parameters and adipocyte size in the obesity animals. In addition, verified that fat degeneration and ballooning degeneration were alleviated in the experimental group fed on a high fat diet combined with LDR groups. These results indicate that lactic acid bacteria-fermented Dioscoreae Rhizoma powder may reduce elevating body weight and lipid accumulation in rat fed a high fat diet, suggesting its usefulness as a functional food for reducing body fat and obesity.
Abstract
The purpose of this study was to examine the antiobesity effects of lactic acid bacteria-fermented Dioscoreae Rhizoma powder (LDR) in Sprague-Dawley rats with high-fat diet (HFD)-induced obesity. Rats were divided into 5 groups: normal diet group, control (high fat diet-vehicle) group, 0.4 g/kg LDR (high fat diet + 0.4 g/kg lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 1 g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 2.5g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group. Our results indicate that LDR administration has effects on decreasing of body weight, fat weight, blood parameters and adipocyte size in the obesity animals. In addition, verified that fat degeneration and ballooning degeneration were alleviated in the experimental group fed on a high fat diet combined with LDR groups. These results indicate that lactic acid bacteria-fermented Dioscoreae Rhizoma powder may reduce elevating body weight and lipid accumulation in rat fed a high fat diet, suggesting its usefulness as a functional food for reducing body fat and obesity.
참고문헌 (31)
- Grundy, S.M., "Multifactorial causation of obesity: Implications for prevention", Am J Clin Nutr, 67, pp.563~572 (1998)
- Whitney, E. N., "Understanding nutrition", pp.264~280 (2005), Thomson Wadsworth
- McGee, D.L., "Body mass index and mortality: a metaanalysis based on person-level data from twenty-six observational studies", Ann Epidemiol, 15, pp.87~97 (2005)
- 이경석, "병원성 식중독 미생물에 대한 천년초 선인장 추출물의 항균 활성", 한국식품영양과학회지, 33(8), pp.1268~1272 (2004), 한국식품영양과학회
- 이영애, "다시마 추출물이 난소를 절제한 흰 쥐의 혈 중 지질 함량에 미치는 영향", 생명과학회지, 18(2), pp.249~254 (2008), 한국생명과학회
- Purseglove, J.W., "Dioscoreaceae: In Longman, I. ed. Tropocal Crops Monocotylodons", pp.97~ (1972), Germany
- McAnuff, M. A., "Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides", Food Chem Toxicol, 43, pp.1667~1672 (2005)
- Hu, K., "The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro", Cancer Invest, 21, pp.389~393 (2003)
- Choi, E. M., "Immune cell stimulating activity of mucopolysaccharide isolated from yam (Dioscorea batatas).", J Ethnopharmacol, 91, pp.1~6 (2004)
- Kim, M. J., "Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis", Int Immunopharmacol, 4, pp.1489~1497 (2004)
- Yin, J., "Antiosteoporotic activity of the water extract of Dioscorea spongiosa", Biol Pharm Bull, 27, pp.583~586 (2004)
- Chen, H. L., "Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudo japonica Yamamoto) on upper gut function and lipid metabolism in Balb", c mice, 2003, pp.19, 646~651
- Lew, E. A., "Mortality and weight: insured lives and the american cancer society studies", Ann Intern Med, 103, pp.1024~1029 (1985)
- Potter, S.M., "Overview of proposed mechanisms for the hypocholesterolemic effect of soy", J Nutr, 125, pp.606S~611S (1995)
- Spiegelman, B.M., "Obesity and the regulation of energy balance", Cell J, 104, pp.531~543 (2001)
- 성수경, "Lactobacillus acidophilus을 이용한 홍경천과 홍삼 혼합 발효물의 이화학적 특성 및 항산화 활성", 한국식품영양학회지, 26(3), pp.358~365 (2013), 한국식품영양학회[DOI]
- 조주현, "가시오가피 버섯균사체 발효물의 기능성 식품 소재 개발", 한국식품영양과학회지, 43(3), pp.411~418 (2014), 한국식품영양과학회
- 이상한, "천마추출물의 항산화 및 항암 활성", 한국식품저장유통학회지, 13(1), pp.83~87 (2006), 한국식품저장유통학회
- 박미란, "발효천마의 총 폴리페놀 함량 변화 및 라디칼 소거능", 한국자원식물학회지, 25(4), pp.379~386 (2012), 한국자원식물학회[DOI]
- 김정미, "발효천마분말의 품질특성과 기호도 조사", 원예과학기술지, 28(3), pp.507~514 (2010), 한국원예학회
- 최재홍, "건천마와 발효천마 추출물의 항노화 활성과 신경성장인자 유도 효과 비교", 원예과학기술지, 31(3), pp.380~387 (2013), 한국원예학회[DOI]
- 김미현, "발효 천마의 기능성 물질 함량 변화 및 항산화 활성", 한국식품영양학회지, 27(4), pp.684~691 (2014), 한국식품영양학회
- Duane, W.C., "Cholesterol metabolism in familial hypertriglyceridemia: effects of obesity versus triglyceride level", J Lab Clin Med, pp.635~642
- Biorntorp, P., "The associations between obesity, adipose tissue distribution and disease", Acta Med Scand, 723, pp.121~134 (1988)
- Asselah, T., "Steatosis in chronic hepatitis C: why does it really matter?", Gut, 55, pp.123~130 (2006)
- Tomkin, G. H., "Atherosclerosis, diabetes and lipoproteins", Expert Rev Cardiovasc Ther, 8, pp.1015~1029 (2010)
- 양민혜, "한국, 중국, 일본에서 자생하는 ‘ 마 ’ 속 식물의 화학 성분과 활성", 생약학회지, 40(4), pp.257~279 (2009), 한국생약학회
- Chung, Y. C., "Effects of blanching, drying and extraction processes on the antioxidant activity of yam (Dioscorea elata)", Int J Food Sci Tech, 43, pp.859~864 (2008)
- 전정례, "Effect of Ethanol Extract of Dried Chinese Yam (Dioscorea batatas) Flour Containing Dioscin on Gastrointestinal Function in Rat Model", Archives of Pharmacal Research, 29(5), pp.348~353 (2006), 대한약학회
- Chen, H., "Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb", c mice, 2003, pp.19, 646~651
- Dzomba, P., "Musekiwa C. Anti-obesity and antioxidant activity of dietary flavonoids from Dioscorea steriscus tubers", J Coast Life Med, 2, pp.465~470 (2014)