고지방 식이로 유도된 비만 백서에서 뽕잎 추출물의 항비만 효과
Anti-obesity Effect of Mulberry Leaves Extraction in Obese Rats High-fat Diet
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초록
The aims of this investigation was to examine the anti-obesity effects of oral administration with Mulberry leaves extraction in the high-fat diet induced obesity rats. We investigated the anti-obesity effects of the extract from Mulberry leaves on the progress of high fat diet for 8 weeks. Experimental rats were divided into 5 different experimental groups including an normal group (normal dieat; n=10), control group (high fat diet; n=10), Ⅰ (Mulberry leaves extraction 100㎎/㎏ oral administration induced obesity; n=10), Ⅱ (Mulberry leaves extraction 300 ㎎/㎏ oral administration; n=10), and Ⅲ (Mulberry leaves extraction 500 ㎎/㎏ oral administration; n=10). It is to analysis changes in body weight, epididymal fat weight, blood lipid profiles, and fat histological findings. Body weights were significantly increase in control group than normal groups(p<0.05). The level of total cholesterol, LDL-C and TG were significantly lower in experimental groups than control group (p<0.05). In histopathologic finding of fat-tissue around testicle experimental groupⅠand Ⅱ were more decreased than high fat diet-induced control group in fat cell size. These results suggested that the Mulberry leaves extraction oral administration made the increase of anti-obesity effect in high-fat diet induced obesity rats.
Abstract
The aims of this investigation was to examine the anti-obesity effects of oral administration with Mulberry leaves extraction in the high-fat diet induced obesity rats. We investigated the anti-obesity effects of the extract from Mulberry leaves on the progress of high fat diet for 8 weeks. Experimental rats were divided into 5 different experimental groups including an normal group (normal dieat; n=10), control group (high fat diet; n=10), Ⅰ (Mulberry leaves extraction 100㎎/㎏ oral administration induced obesity; n=10), Ⅱ (Mulberry leaves extraction 300 ㎎/㎏ oral administration; n=10), and Ⅲ (Mulberry leaves extraction 500 ㎎/㎏ oral administration; n=10). It is to analysis changes in body weight, epididymal fat weight, blood lipid profiles, and fat histological findings. Body weights were significantly increase in control group than normal groups(p<0.05). The level of total cholesterol, LDL-C and TG were significantly lower in experimental groups than control group (p<0.05). In histopathologic finding of fat-tissue around testicle experimental groupⅠand Ⅱ were more decreased than high fat diet-induced control group in fat cell size. These results suggested that the Mulberry leaves extraction oral administration made the increase of anti-obesity effect in high-fat diet induced obesity rats.
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