춘천 지역 중년 및 노인에서의 혈청 감마지티피와 공복혈당장애의 유병률과의 상관관계: 한림노년연구
Association of Serum Gamma Glutamyltransferase and Fasting Blood Glucose among Middle Aged and Elderly in Chuncheon : Hallym Aging Study
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연구배경: 최근 감마지티피(GGT)는 제 2형 당뇨병, 많은 심혈관 질환의 위험 요인, 대사증후군의 요소들과 연관이 있다고 밝혀졌다. 공복혈당장애(IFG)는 당뇨병의 전기로서 심혈관 질환의 위험과 연관이 있다고 알려져 있다. 본 연구에서는 GGT와 IFG의 유병률의 관련성을 단면조사 연구로 알아보고자 하였다. 방법: 춘천 지역에 거주하고 있는 45세 이상 주민 중 무작위로 선정된 지역에서 계통 추출된 1514명을 선정하였다. 선정된 대상자 중 검사에 응한 918명 중 당뇨로 진단된 기왕력 및 GGT, 공복혈당의 결측치, 간의 기존손상이 있을 것이라고 예상되는 사람, 측정된 공복혈당이 당뇨의 진단기준 해당되는 경우를 제외한 최종 693명(남자 272명, 여자 421명)을 최종 연구 대상으로 하였다. GGT는 값에 따라 4군으로 나누었으며 각 군별 IFG 유병률의 대응 위험도는 로짓 회귀분석을 이용하여 제시하였다. 결과: 남자에서만 GGT에 따른 IFG 유병률의 대응 위험도가 통계적 유의성을 보였다. 모든 변수를 보정한 후, GGT 참고군(0-16 IU/L)에 비해 2, 3, 4군의 IFG 유병률의 대응 위험도는 0.56, 1.57, 2.79이었다(P-value for trend 0.022). 여자에서는 GGT에 따른 IFG 유병률의 대응 위험도가 통계적 유의성을 보이지 않았다. 결론: 중년 이상 남자에서 GGT는 공복혈당장애와 독립적인 연관성이 있음을 알 수 있었다.
Abstract
Background: Serum gamma-glutamyltransferase (GGT) was reported to be associated with type 2 diabetes, various cardiovascular disease risk factors, and individual components of metabolic syndrome. We performed a cross-sectional study to elucidate the relations between GGT and impaired fasting glucose (IFG). Methods: The subject of this study included 693 adults (males 272, females 421) aged 45 years or over who have lived in Chuncheon, a suburban small-sized city. IFG was defined as elevated fasting plasma glucose (FPG) concentration of ≥ 100 and < 126 mg/dl. Results: The risk of IFG appeared to increase with increasing levels of serum GGT even after adjusting for other covariates, such as body mass index and inflammatory markers among men only: adjusted odds ratios of IFG across GGT categories (< 25th, < 50th, < 75th and ≥ 75th) were 1.0, 0.56, 1.57, and 2.79, respectively (P-value for trend 0.022). In women, the association between the risk of IFG and GGT was not statistically significant. Conclusion: This study suggests that elevated level of GGT within the normal range is an independent predictor of impaired fasting glucose in middle-aged or older men but not in women.
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