기무라병에서 발생한 급성 뇌경색증, 깊은정맥혈전증, 폐색전증
Acute Cerebral Infarction, Deep Vein Thrombosis and Pulmonary Embolism in Kimura’s Disease Acute Cerebral Infarction, Deep Vein Thrombosis and Pulmonary Embolism in Kimura’s Disease
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Kimura’s disease is a chronic infl ammatory disease producing subcutaneous tumor-like nodules chiefl y in the head and neck region. It is characterized histologically by lymphoid follicles, intense aggregations of eosinophils, vascular proliferation and fi -brosis combined with peripheral blood eosinophilia. We report a 56-year-old man who presented with dysarthria and right hemiparesis. On physical examination, a non-ender mass 5 × 6 cm was identifi ed in the right submandibular area. He was diagnosed with Kimura’s disease by biopsy. One month after admission, he complained of paresthesia in the left lower extremity. CT angiography revealed thromobosis in the left femoral vein and bilateral pulmonary embolism. To our knowledge, the concomitant occurrence of acute cerebral infarction, deep vein thrombosis and pulmonary embolism in patients with Kimura’s disease has never been reported. Eosinophil-derived cytotoxic proteins are presumed to be fundamental to the pathogenesis of these disorders in Kimura’s disease. (Korean J Stroke 2011;13:85-88)
Abstract
Kimura’s disease is a chronic infl ammatory disease producing subcutaneous tumor-like nodules chiefl y in the head and neck region. It is characterized histologically by lymphoid follicles, intense aggregations of eosinophils, vascular proliferation and fi -brosis combined with peripheral blood eosinophilia. We report a 56-year-old man who presented with dysarthria and right hemiparesis. On physical examination, a non-ender mass 5 × 6 cm was identifi ed in the right submandibular area. He was diagnosed with Kimura’s disease by biopsy. One month after admission, he complained of paresthesia in the left lower extremity. CT angiography revealed thromobosis in the left femoral vein and bilateral pulmonary embolism. To our knowledge, the concomitant occurrence of acute cerebral infarction, deep vein thrombosis and pulmonary embolism in patients with Kimura’s disease has never been reported. Eosinophil-derived cytotoxic proteins are presumed to be fundamental to the pathogenesis of these disorders in Kimura’s disease. (Korean J Stroke 2011;13:85-88)
참고문헌 (9)
- Bogousslavsky J, "Uncommon Causes of Stroke. 1st ed", pp.356~357 (2001), Cambridge University Press
- Kwon SU, "Sequential magnetic resonance imaging findings in hypereosinophilia-induced encephalopathy", J Neurol, 248, pp.279~284 (2001)
- Kaplan PW, "Reversible dementia with idiopathic hypereosinophilic syndrome", Neurology, 39, pp.1388~1391 (1989)
- Wichman A, "Peripheral neuropathy in hypereosinophilic syndrome", Neurology, 35, pp.1140~1145 (1985)
- Mukai HY, "Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia", Br J Haematol, 90, pp.892~899 (1995)
- Weaver DF, "Eosinophilinduced neurotoxicity: axonal neuropathy, cerebral infarction, and dementia", Neurology, 38, pp.144~146 (1988)
- Nagashima T, "Images in cardiovascular medicine. Kimura’s disease presenting as steroidresponsive thromboangiitis obliterans", Circulation, 114, pp.e10~e11 (2006)
- Tamaki T, "Occlusion of internal carotid artery in Kimura’s disease", Case Report Med, 2010, pp.407538~ (2010)
- Liu H, "Thrombotic storm in Kimura disease", J Thromb Thrombolysis, 29, pp.354~357 (2010)