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과다호산구증후군과 연관된 뇌경색 병변의 양상

Different Lesion Patterns in Cerebral Infarction Associated with Hypereosinophilic Syndrome

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초록

Hypereosinophilic syndrome is a rare disorder that can cause ischemic stroke. We report two patients with cerebral infarction due to hypereosinophilic syndrome. Brain MRI of each patient revealed different lesion patterns of cerebral infarcts, which included multiple border-zone infarcts and a small perforating-artery infarct. The mechanism underlying the small infarct in one of the patients was presumed to be vascular endothelial toxicity by eosinophilic cells and local thrombus formation, and the distinguishing lesion pattern of this patient has not been reported previously.

Abstract

Hypereosinophilic syndrome is a rare disorder that can cause ischemic stroke. We report two patients with cerebral infarction due to hypereosinophilic syndrome. Brain MRI of each patient revealed different lesion patterns of cerebral infarcts, which included multiple border-zone infarcts and a small perforating-artery infarct. The mechanism underlying the small infarct in one of the patients was presumed to be vascular endothelial toxicity by eosinophilic cells and local thrombus formation, and the distinguishing lesion pattern of this patient has not been reported previously.

참고문헌 (10)

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  8. Wang JG, "The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states", Blood, 107, pp.558~565 (2006)
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  10. Kwon SU, "Sequential magnetic resonance imaging findings in hypereosinophilia-induced encephalopathy", J Neurol, 248, pp.279~284 (2001)

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