허혈성 뇌졸중의 동물 모델
Rat Models for Ischemic Stroke
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초록
Highly reproducible and consistent ischemic stroke models are critical for obtaining more confi dent data. To date, the infarct variation of several ischemic rat models is considerable. Therefore, many factors related to outcome variation and infarct growth must be controlled. Among various infarct models of rodents, intraluminal fi lament model is common by virtue of its consistency of the success rate and the outcomes. Recently more long-term evaluation of functional and imaging outcomes is considered in terms of clinical practice. Concise and subsequent outcome assessment could result in the improvement of translational stroke research. We recommend that the researchers should remember the guidelines addressed by the Stroke Therapy Academic Industry Roundtable (STAIR) and the Good Laboratory Practice (GLP). (Korean J Stroke 2011;13:107-113)
Abstract
Highly reproducible and consistent ischemic stroke models are critical for obtaining more confi dent data. To date, the infarct variation of several ischemic rat models is considerable. Therefore, many factors related to outcome variation and infarct growth must be controlled. Among various infarct models of rodents, intraluminal fi lament model is common by virtue of its consistency of the success rate and the outcomes. Recently more long-term evaluation of functional and imaging outcomes is considered in terms of clinical practice. Concise and subsequent outcome assessment could result in the improvement of translational stroke research. We recommend that the researchers should remember the guidelines addressed by the Stroke Therapy Academic Industry Roundtable (STAIR) and the Good Laboratory Practice (GLP). (Korean J Stroke 2011;13:107-113)
참고문헌 (25)
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