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Immunoglobulin G4-Related Inflammatory Pseudotumor Presenting as a Solitary Mass in the Stomach

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초록

Immunoglobulin G4 (IgG4)-related disease (IgG4RD) is a relatively recently recognized entity that is histopathologically characterized by an extensive infiltration of lymphocytes and IgG4-positive plasma cells with dense fibrosis. IgG4RD is now known to affect any organ system, and a few cases of gastrointestinal lesions have also been reported. However, solitary IgG4RD of the stomach is still very rare. Furthermore, as it can mimic malignant conditions, it is important to recognize this disease to avoid unnecessary surgery. Herein, we present a case of IgG4RD presenting as an isolated subepithelial mass in the stomach.

Abstract

Immunoglobulin G4 (IgG4)-related disease (IgG4RD) is a relatively recently recognized entity that is histopathologically characterized by an extensive infiltration of lymphocytes and IgG4-positive plasma cells with dense fibrosis. IgG4RD is now known to affect any organ system, and a few cases of gastrointestinal lesions have also been reported. However, solitary IgG4RD of the stomach is still very rare. Furthermore, as it can mimic malignant conditions, it is important to recognize this disease to avoid unnecessary surgery. Herein, we present a case of IgG4RD presenting as an isolated subepithelial mass in the stomach.

참고문헌 (12)

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  2. Stone JH, "IgG4-related disease", N Engl J Med, 366, pp.539~551 (2012)
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  4. Kanno A, "Autoimmune pancreatitis with hepatic inflammatory pseudotumor", Pancreas, 31, pp.420~423 (2005)
  5. Zen Y, "IgG4-positive plasma cells in inflammatory pseudotumor(plasma cell granuloma)of the lung", Hum Pathol, 36, pp.710~717 (2005)
  6. 차동혁, "대망에 발생한 IgG4 연관 염증성 가성종양 1예", 대한내과학회지, 84(3), pp.400~404 (2013), 대한내과학회[DOI]
  7. Rollins KE, "Gastric IgG4-related autoimmune fibrosclerosing pseudotumour: a novel location", ISRN Gastroenterol, 2011, pp.873087~ (2011)
  8. Chetty R, "Sclerosing nodular lesions of the gastrointestinal tract containing large numbers of IgG4plasma cells", Pathology, 43, pp.31~35 (2011)
  9. Na KY, "Gastric nodular lesion caused by IgG4-related disease", Pathol Int, 62, pp.716~718 (2012)
  10. Kim do H, "Immunoglobulin G4-related inflammatory pseudotumor of the stomach", Gastrointest Endosc, 76, pp.451~452 (2012)
  11. Fujita T, "Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: a case report", World J Gastroenterol, 16, pp.2183~2186 (2010)
  12. Bateman AC, "Chronic gastric ulceration:a novel manifestation of IgG4-related disease?", J Clin Pathol, 65, pp.569~570 (2012)

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