특발성혈소판감소증에서 위나선균 제균요법의 효과 : 세 가지 증례 보고
Effect of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: Report of 3 cases
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
There are several reports suggesting Helicobacter pylori can initiate and perpetuate idiopathic thrombocytopenic purpura (ITP) and eradication of H. pylori can increase the platelet counts, however, the prevalence of H. pylori infection in patients with ITP is similar to that found in the general population and a recovery of thrombocytopenia after H. pylori eradication therapy has not been identified reliably. We report three different cases of H. pylori infected patients with ITP who recovered completely after eradication of H. pylori. The first case was refractory, the second was recurred after conventional treatment for ITP, and the third was treated with H. pylori eradication on first line treatment. We believe that the eradication of H. pylori is useful in some patients with ITP in Korea and well controlled randomized study is necessary for further identification of such population. (Korean J Med 74:330-335, 2008)
Abstract
There are several reports suggesting Helicobacter pylori can initiate and perpetuate idiopathic thrombocytopenic purpura (ITP) and eradication of H. pylori can increase the platelet counts, however, the prevalence of H. pylori infection in patients with ITP is similar to that found in the general population and a recovery of thrombocytopenia after H. pylori eradication therapy has not been identified reliably. We report three different cases of H. pylori infected patients with ITP who recovered completely after eradication of H. pylori. The first case was refractory, the second was recurred after conventional treatment for ITP, and the third was treated with H. pylori eradication on first line treatment. We believe that the eradication of H. pylori is useful in some patients with ITP in Korea and well controlled randomized study is necessary for further identification of such population. (Korean J Med 74:330-335, 2008)
참고문헌 (20)
- Graham DY, "Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model", Gastroenterology, 113, pp.1983~1991 (1997)
- Claeys D, "The gastric H+, K+‐ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy", Gastroenterology, 115, pp.340~347 (1998)
- Pasceri V, "Association of virulent Helicobacter pylori strains with ischemic heart disease", Circulation, 97, pp.1675~1679 (1998)
- Gasbarrini A, "Autoimmune disease and Helicobacter pylori infection", Biomed Pharmacother, 53, pp.223~226 (1999)
- Annibale B, "Role of Helicobacter pylori infection in pernicious anaemia", Dig Liver Dis, 32, pp.756~762 (2000)
- Gasbarrini A, "Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori", Lancet, 352, pp.878~ (1998)
- Kohda K, "Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura", Br J Haematol, 118, pp.584~588 (2002)
- Suzuki T, "Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenia purpura: a randomized controlled trial", Am J Gastroenterol, 100, pp.1265~1270 (2005)
- Michel M, "Autoimmune thrombocytopenic purpura and Helicobacter pylori infection", Arch Intern Med, 162, pp.1033~1036 (2002)
- Jarque I, "Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura", Br J Haematol, 115, pp.1002~1003 (2001)
- 김용주, "소아 철결핍성 빈혈과 위장관 질환", 소아과, 42, pp.697~703 (1999)
- Choi DS, "Resolution of chronic idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori: a case report", Korean J Hematol, 38, pp.270~273 (2003)
- Kim BS, "The clinical efficacy of Helicobacter pylori eradication in patients with Helicobacter pylori‐positive chronic thrombocytopenic purpura", Korean J Hematol, 40, pp.23~27 (2005)
- He R, "Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura", Blood, 83, pp.1024~1032 (1994)
- George JN, "Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology", Blood, 88, pp.3~40 (1996)
- Leontiadis GI, "Non‐gastrointestinal tract associations of Helicobacter pylori infection", Arch Intern Med, 159, pp.925~940 (1999)
- Showji Y, "Seroprevalence of Helicobacter pylori infection in patients with connective tissue diseases", Microbiol Immunol, 40, pp.499~503 (1996)
- Veneri D, "Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura", Haematologica, 87, pp.1177~1179 (2002)
- Takahashi T, "Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori‐associated chronic idiopathic thrombocytopenic purpura", Br J Haematol, 124, pp.91~96 (2004)
- Evans DJ Jr, "Helocibacter pylori CagA: analysis of sequence diversity in relation to phosphorylation morifs and implications for the role of CagA as a virulence factor", Helicobactor, 6, pp.187~198 (2001)