The Effects of Helicobacter pylori Eradication Therapy for Chronic Idiopathic Thrombocytopenic Purpura
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Background/Aims: The aim of this study was to evaluate the ability of Helicobacter pylori eradication treatment to increase platelet counts in Korean patients with chronic idiopathic thrombocytopenic purpura (ITP). Methods: A total of 102 patients were evaluated against two criteria. First, those diagnosed with H. pylori infections in whom eradication was successful were assigned to the H. pylori-positive and -eradicated group (n=39), whereas those diagnosed with H. pylori infections in whom eradication failed were assigned to the H. pylori-positive and -non-eradicated group (n=3), and those without H. pylori infections were assigned to the H. pylori - negative group (n=60). Second, patients with complete remission in whom the platelet recovery effect was maintained over the average follow-up period of 6 months after eradication therapy were defined as the responder group (n=58), whereas those with partial or no response were defined as the nonresponder group (n=44). Results: The platelet counts of the H. pylori-positive and -eradicated group were significantly increased 6 months after eradication therapy compared to those of the H. pylori-positive and -non-eradicated group and the H. pylori-negative group (43.2±29.1 to 155.3±68.7×103/μL vs 42.5±28.1 to 79.8±59.7×103/μL vs 43.1±28.9 to 81.2±62.2×103/μL; p=0.041). The eradication therapy success rate in the responder group was 100.0% (39/39), in contrast to the nonresponder group (0%, 0/3) (p<0.001). Conclusions: H. pylori eradication therapy was related to increased platelet count, and successful eradication affected the increased platelet count in Korean patients with chronic ITP.
Abstract
Background/Aims: The aim of this study was to evaluate the ability of Helicobacter pylori eradication treatment to increase platelet counts in Korean patients with chronic idiopathic thrombocytopenic purpura (ITP). Methods: A total of 102 patients were evaluated against two criteria. First, those diagnosed with H. pylori infections in whom eradication was successful were assigned to the H. pylori-positive and -eradicated group (n=39), whereas those diagnosed with H. pylori infections in whom eradication failed were assigned to the H. pylori-positive and -non-eradicated group (n=3), and those without H. pylori infections were assigned to the H. pylori - negative group (n=60). Second, patients with complete remission in whom the platelet recovery effect was maintained over the average follow-up period of 6 months after eradication therapy were defined as the responder group (n=58), whereas those with partial or no response were defined as the nonresponder group (n=44). Results: The platelet counts of the H. pylori-positive and -eradicated group were significantly increased 6 months after eradication therapy compared to those of the H. pylori-positive and -non-eradicated group and the H. pylori-negative group (43.2±29.1 to 155.3±68.7×103/μL vs 42.5±28.1 to 79.8±59.7×103/μL vs 43.1±28.9 to 81.2±62.2×103/μL; p=0.041). The eradication therapy success rate in the responder group was 100.0% (39/39), in contrast to the nonresponder group (0%, 0/3) (p<0.001). Conclusions: H. pylori eradication therapy was related to increased platelet count, and successful eradication affected the increased platelet count in Korean patients with chronic ITP.
참고문헌 (26)
- Graham DY., "Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: a model", Gastroenterology, 113, pp.1983~1991 (1997)
- Pasceri V, "Association of virulent Helicobacter pylori strains with ischemic heart disease", Circulation, 97, pp.1675~1679 (1998)
- Gasbarrini A, "Autoimmune diseases and Helicobacter pylori infection", Biomed Pharmacother, 53, pp.223~226 (1999)
- Annibale B, "Role of Helicobacter pylori infection in pernicious anaemia", Dig Liver Dis, 32, pp.756~762 (2000)
- Gasbarrini A, "Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori", Lancet, 352, pp.878~ (1998)
- Kohda K, "Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura", Br J Haematol, 118, pp.584~588 (2002)
- Suzuki T, "Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpura: a randomized controlled trial", Am J Gastroenterol, 100, pp.1265~1270 (2005)
- Michel M, "Autoimmune thrombocytopenic Purpura and Helicobacter pylori infection", Arch Intern Med, 162, pp.1033~1036 (2002)
- Jarque I, "Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura", Br J Haematol, 115, pp.1002~1003 (2001)
- George JN, "Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology", Blood, 88, pp.3~40 (1996)
- Rodeghiero F, "Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group", Blood, 113, pp.2386~2393 (2009)
- Rostami N, "Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial", Am J Hematol, 83, pp.376~381 (2008)
- Stasi R, "Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review", Blood, 113, pp.1231~1240 (2009)
- Emilia G, "Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura", Blood, 97, pp.812~814 (2001)
- Arnold DM, "Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review", Haematologica, 94, pp.850~856 (2009)
- Franchini M, "Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis", J Antimicrob Chemother, 60, pp.237~246 (2007)
- Fujimura K, "Is eradication therapy useful as the first line of treatment in Helicobacter pylori-positive idiopathic thrombocytopenic purpura? Analysis of 207 eradicated chronic ITP cases in Japan", Int J Hematol, 81, pp.162~168 (2005)
- Michel M, "Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?", Blood, 103, pp.890~896 (2004)
- Takahashi T, "Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura", Br J Haematol, 124, pp.91~96 (2004)
- Veneri D, "Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura", Haematologica, 87, pp.1177~1179 (2002)
- Hino M, "Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura", Ann Hematol, 82, pp.30~32 (2003)
- Ando K, "Can eradication therapy for Helicobacter pylori really improve the thrombocytopenia in idiopathic thrombocytopenic purpura? Our experience and a literature review", Int J Hematol, 77, pp.239~244 (2003)
- 김나영, "헬리코박터 파일로리 감염의 진단 및 치료 가이드라인", 대한소화기학회지, 54(5), pp.269~278 (2009), 대한소화기학회
- Malfertheiner P, "Management of Helicobacter pylori infection: the Maastricht IV", Florence Consensus Report, 2012, pp.61, 646~664
- Asaka M, "Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition", Helicobacter, 15, pp.1~20 (2010)
- Fock KM, "Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection", J Gastroenterol Hepatol, 24, pp.1587~1600 (2009)