헬리코박터 파이로리 감염과 혈액학적 이상
Helicobacter pylori and Hematologic Diseases
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초록
아직까지 발생기전이 명확히 밝혀지지는 않았으나, 역학연구, 무작위 대조군 연구 그리고 메타 분석에서 헬리코박터파이로리는 특발성 혈소판 감소증 및 원인 미상의 철결핍성빈혈 같은 혈액학적 이상과의 관련 및 헬리코박터 파이로리제균 후 질환의 호전이 보고되고 있다. 헬리코박터 파이로리에 감염된 특발성 혈소판 감소증 환자 및 내시경을 포함한모든 검사에서 헬리코박터 파이로리 감염을 제외하고는 정상 소견이며, 철분을 투여해도 치료가 되지 않는 난치성 철결핍성빈혈 환자의 경우 헬리코박터 파이로리의 제균을 시도해보는 것을 추천한다.
Abstract
Helicobacter pylori has been considered as the possible etiology in many extragastric disease. Hematologic diseases such as immune thrombocytopenic purpura (ITP) and iron-deficiency anemia have been proposed to associate with H. pylori infection,although the hypothesis of an etiological role has not yet been fully investigated. Systematic reviews and meta-analysis have shown a significant increase of platelet counts in ITP patients in whom eradiation was successful compared with untreated, failed eradication or H. pylori-negative patients. H. pylori infection has emerged as a one of causes of refractory iron-deficiency anemia which is unresponsiveness to oral iron therapy. A link between H. pylori infection and iron- deficiency anemia was shown in recent meta-analyses and H. pylori eradication increased hemoglobin levels in these patients. The effect of H. pylori on iron stores may be greatest in those with marginal dietary iron intake or other stressors of iron stores. The guideline of Korean College of Helicobacter and Upper Gastrointestinal Research (2009) and other guidelines of western and Japan recommend that H. pylori should be sought and eradicated in the patients with ITP and unexplained iron-deficiency anemia.
참고문헌 (30)
- 김나영, "헬리코박터 파일로리 감염의 진단 및 치료 가이드라인", 대한소화기학회지, 54(5), pp.269~278 (2009), 대한소화기학회
- Malfertheiner P, "Management of Helicobacter pylori infection : the Maastricht IV", Florence Consensus Report, 2012, pp.61, 646~664
- Asaka M, "Guidelines for the management of Helicobacter pylori infection in Japan : 2009 revised edition", Helicobacter, 15, pp.1~20 (2010)
- Fock KM, "Second Asia-pacific consensus guidelines for Helicobacter pylori infection", J Gastroenterol Hepatol, 24, pp.1587~1600 (2009)
- Chey WD, "American College of Gastroenterology guideline on the management of Helicobacter pylori infection", Am J Gastroenterol, 102, pp.1808~1825 (2007)
- Imbach P, "Local and cultural aspects of childhood idiopathic thrombocytopenic purpura: a summary of statements from the 12 countries worldwide", J Pediatr Hematol Oncol, 25(1), pp.68~73 (2003)
- Rodeghiero F, "definitions and outcome criteria in immune thrombocytopenic purpura of adults and children : report from an international working group", Blood, 113, pp.2386~2393 (2009)
- Gasbarrini A, "Gasbarrini G. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori", Lancet, 352, pp.878~ (1998)
- Hee Sang Tag, "Effects of Helicobacter pylori eradication in patients with immune thrombocytopenic purpura", Blood Research, 45(2), pp.127~132 (2010), 대한혈액학회
- Ianaro A, "Anti-inflammatory activity of macrolide antibiotics", J Pharmacol Exp Ther, 292, pp.156~163 (2000)
- Liebman HA, "Secondary immune thrombocytopenic purpura", Curr Opin Hematol, 14, pp.557~573 (2007)
- Arnold DM, "Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review", Haematologica, 94, pp.850~856 (2009)
- Franchini M, "Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura : a systematic review and meta-analysis", J Antimicrob Chemother, 60, pp.237~246 (2007)
- Scandellari R, "Platelet response to Helicobacter pylori eradication therapy in adult chronic idiopathic thrombocytopenic purpura seems to be related to the presence of anticytotoxin-associated gene A antibodies", Blood Coagul Fibrinolysis, 20, pp.108~113 (2009)
- Takahashi T, "Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura", Br J Haematol, 124, pp.91~96 (2004)
- Sato R, "Effect of Helicobacter pylori eradication on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura", Arch Intern Med, 164, pp.1904~1907 (2004)
- Blecker U, "Syncopes leading to the diagnosis of a Helicobacter pylori positive chronic active haemorrhagic gastritis", Eur J Pediatr, 150, pp.560~561 (1991)
- Choe YH, "Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents", Helicobacter, 4, pp.135~139 (1999)
- Barabino A, "Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children : further clinical evidence", J Pediatr Gastroenterol Nutr, 28, pp.116~119 (1999)
- Milman N, "Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults", Gastroenterology, 115, pp.268~274 (1998)
- Berg G, "Helicobacter pylori infection and serum ferritin : a populationbased study among 1806 adults in Germany", Am J Gastroenterol, 96, pp.1014~1018 (2001)
- Choe YH, "Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty", Arch Dis Child, 82, pp.136~140 (2000)
- Muhsen K, "Helicobacter pylori infection and iron stores : a systematic review and meta-analysis", Helicobacter, 13, pp.323~340 (2008)
- Qu XH, "Does Helicobacter pylori infection play a role in iron deficiency anemia? a metaanalysis", World J Gastroenterol, 16, pp.886~896 (2010)
- Yuan W, "Iron deficiency anemia in Helicobacter pylori infection : meta-analysis of randomized controlled trials", Scand J Gastroenterol, 45, pp.665~676 (2010)
- Collett JA, "Seroprevalence of Helicobacter pylori in the adult population of Christchurch : risk factors and relationship to dyspeptic symptoms and iron studies", N Z Med J, 112, pp.292~295 (1999)
- Choi JW., "Does Helicobacter pylori infection relate to iron deficiency anaemia in prepubescent children under 12 years of age?", Acta Paediatr, 92, pp.970~972 (2003)
- Nakao K, "Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation", Am J Gastroenterol, 92, pp.1005~1011 (1997)
- Choe YH, "Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa", J Gastroenterol Hepatol, 18, pp.980~985 (2003)
- Annibale B, "Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia", Gut, 52, pp.496~501 (2003)