유방암을 동반한 제2형 다발성 내분비 선종증 1예
A case of breast cancer in a patient with multiple endocrine neoplasia type 2
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초록
제2형 다발성 내분비 선종은 한 환자에게서 갑상선수질암, 갈색세포종과 다른 내분비 조직의 과형성 혹은 종양 형성을 특징으로 하는 희귀한 유전성 질환이다. MEN2는 여러 종류의 종양을 발생시키지만 유방암과 같이 다른 기원을 가지는 종양을 동반하는 경우는 매우 드문 일이며 아직까지 MEN2와 유방암 발생의 병태생리적인 관계는 잘 알려져 있지 않다. 저자들은 갑상선수질암과 갈색세포종으로 진단된 MEN2 환자에서 유방암이 병발된 1예를 경험하였기에 문헌고찰과 함께 보고한다.
Abstract
Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare hereditary complex disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and other hyperplasias or neoplasias of different endocrine tissues within a single patient. Simultaneous occurrence of MEN2 and other cancers that are derived from different origins is rare. In this report, we present a patient with known MEN2 who developed breast cancer as a result of invasive ductal carcinoma. The patient underwent total thyroidectomy and unilateral adrenalectomy due to medullary thyroid cancer and pheochromocytoma. Although patients with MEN2 may demonstrate a variety of neoplastic disorders, it is difficult to identify a case report of MEN2 with breast cancer. In addition, no etiological relationships between breast cancer and MEN2 have been reported to date. Thus, here we report a case of known MEN2 with breast cancer and present a review of the literature.
참고문헌 (19)
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