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간선종과 국소결절성과증식

Hepatocellular Adenoma and Focal Nodular Hyperplasia

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대한내과학회 (The Korean Association Of Internal Medicine)|2013.03|대한내과학회지 (The Korean Journal of Medicine)|제84권 제3호|pp. 325-332|DOI http://dx.doi.org/10.3904/kjm.2013.84.3.325

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참고문헌

키워드

Focal nodular hyperplasiaHepatocellular adenoma양성 간종양간선종국소결절성과증식Benign hepatic tumor
주제분류내과학

초록

간선종과 국소결절성과증식은 간세포암과 감별해야 할, 드물지만 중요한 양성 간종양이다. 대부분 기저 간질환 여부와 임상적 상황 및 영상 검사 결과를 종합하여 감별 진단이 가능하지만 때로는 감별이 어려워 확진을 위한 수술적 절제가 필요한 경우도 드물게 발생한다. 이러한 간내 고형 병변의 진단 및 치료를 위한 알고리듬을 반드시 숙지해서 불필요한 검사와 치료가 시행되지 않도록 유념해야 한다(Fig. 1).

Abstract

Recent advances in imaging technologies have offered us a great chance to detect a variety of focal liver lesions. Accordingly, it is of paramount importance to determine whether these focal liver lesions are malignant or nonmalignant. Some benign hepatic tumors mimicking hepatocellular carcinoma typically develop from either regenerative or dysplastic/neoplastic processes. The most common benign hepatic solid tumors that are not of vascular origin include focal nodular hyperplasia and hepatocellular adenoma. A majority of patients with benign hepatic tumors are often asymptomatic and require no specific treatment. However, surgical resection may be infrequently needed for cases with clinical symptoms or malignant potential. This review will touch on the epidemiology, pathogenesis, clinical features, diagnosis, and management of focal nodular hyperplasia and hepatocellular adenoma.

참고문헌 (65)

  1. Grazioli L, "Hepatic adenomas : imaging and pathologic findings", Radiographics, 21, pp.877~892 (2001)
  2. Sherlock S, "Hepatic adenomas and oral contraceptives", Gut, 16, pp.753~756 (1975)
  3. Klatskin G, "Hepatic tumors : possible relationship to use of oral contraceptives", Gastroenterology, 73, pp.386~394 (1977)
  4. Baum JK, "Possible association between benign hepatomas and oral contraceptives", Lancet, 2, pp.926~929 (1973)
  5. Edmondson HA, "Liver-cell adenomas associated with use of oral contraceptives", N Engl J Med, 294, pp.470~472 (1976)
  6. Rooks JB, "Epidemiology of hepatocellular adenoma : the role of oral contraceptive use", JAMA, 242, pp.644~648 (1979)
  7. Nime F, "The histology of liver tumors in oral contraceptive users observed during a national survey by the American College of Surgeons Commission on Cancer", Cancer, 44, pp.1481~1489 (1979)
  8. Rosenberg L, "The risk of liver neoplasia in relation to combined oral contraceptive use", Contraception, 43, pp.643~652 (1991)
  9. Søe KL, "Liver pathology associated with the use of anabolic-androgenic steroids", Liver, 12, pp.73~79 (1992)
  10. Reddy KR, "Approach to a liver mass", Semin Liver Dis, 13, pp.423~435 (1993)
  11. Shortell CK, "Hepatic adenoma and focal nodular hyperplasia", Surg Gynecol Obstet, 173, pp.426~431 (1991)
  12. Meissner K, "Hemorrhage caused by ruptured liver cell adenoma following long-term oral contraceptives : a case report", Hepatogastroenterology, 45, pp.224~225 (1998)
  13. Edmondson HA, "Regression of liver cell adenomas associated with oral contraceptives", Ann Intern Med, 86, pp.180~182 (1977)
  14. Kawakatsu M, "Disappearance of liver cell adenoma : CT and MR imaging", Abdom Imaging, 22, pp.274~276 (1997)
  15. Aseni P, "Rapid disappearance of hepatic adenoma after contraceptive withdrawal", J Clin Gastroenterol, 33, pp.234~236 (2001)
  16. Maillette de Buy Wenniger L, "Focal nodular hyperplasia and hepatic adenoma : epidemiology and pathology", Dig Surg, 27, pp.24~31 (2010)
  17. Scheuer P, "Neoplasms and nodules, In Liver Biopsy Interpretation. 6th ed", pp.191~ (2000), WB Saunders
  18. Zucman-Rossi J, "Genotypephenotype correlation in hepatocellular adenoma : new classification and relationship with HCC", Hepatology, 43, pp.515~524 (2006)
  19. Laumonier H, "Hepatocellular adenomas : magnetic resonance imaging features as a function of molecular pathological classification", Hepatology, 48, pp.808~818 (2008)
  20. Ronot M, "Hepatocellular adenomas : accuracy of magnetic resonance imaging and liver biopsy in subtype classification", Hepatology, 53, pp.1182~1191 (2011)
  21. Leese T, "A 12-year surgical experience from a specialist hepato-biliary unit", Ann Surg, 208, pp.558~564 (1988)
  22. Nagorney DM, "Benign hepatic tumors : focal nodular hyperplasia and hepatocellular adenoma", World J Surg, 19, pp.13~18 (1995)
  23. Rubin RA, "Evaluation of the solid hepatic mass", Med Clin North Am, 80, pp.907~928 (1996)
  24. Cherqui D, "Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations", Hepatology, 22, pp.1674~1681 (1995)
  25. Kerlin P, "Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features", Gastroenterology, 84(5), pp.994~1002 (1983)
  26. Foster JH, "The malignant transformation of liver cell adenomas", Arch Surg, 129, pp.712~717 (1994)
  27. Chung KY, "Hepatocellular adenoma : MR imaging features with pathologic correlation", AJR Am J Roentgenol, 165, pp.303~308 (1995)
  28. Paulson EK, "Hepatic adenoma : MR characteristics and correlation with pathologic findings", AJR Am J Roentgenol, 163, pp.113~116 (1994)
  29. Arrivé L, "Hepatic adenoma : MR findings in 51 pathologically proved lesions", Radiology, 193, pp.507~512 (1994)
  30. Grazioli L, "Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging : prospective study", Radiology, 236, pp.166~177 (2005)
  31. Grazioli L, "Hepatocellular adenoma and focal nodular hyperplasia : value of gadoxetic acid-enhanced MR imaging in differential diagnosis", Radiology, 262, pp.520~529 (2012)
  32. Dokmak S, "A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas", Gastroenterology, 137, pp.1698~1705 (2009)
  33. Bioulac-Sage P, "Hepatocellular adenoma management and phenotypic classification : the Bordeaux experience", Hepatology, 50, pp.481~489 (2009)
  34. Sherlock S, "Hepatic reactions to drugs", Gut, 20, pp.634~648 (1979)
  35. Monks PL, "Spontaneous rupture of an hepatic adenoma in pregnancy with survival of mother and fetus", Aust N Z J Obstet Gynaecol, 26, pp.155~157 (1986)
  36. Estebe JP, "Spontaneous rupture of an adenoma of the liver during pregnancy", J Chir (Paris), 125, pp.654~656 (1988)
  37. Terkivatan T, "Management of hepatocellular adenoma during pregnancy", Liver, 20, pp.186~187 (2000)
  38. Belghiti J, "Resection of presumed benign liver tumours", Br J Surg, 80, pp.380~383 (1993)
  39. Mueller J, "Liver transplantation for treatment of giant hepatocellular adenomas", Liver Transpl Surg, 1, pp.99~102 (1995)
  40. Tepetes K, "Orthotopic liver transplantation for benign hepatic neoplasms", Arch Surg, 130, pp.153~156 (1995)
  41. Yoshidome H, "Management issues regarding hepatic adenomatosis", Am Surg, 65, pp.1070~1076 (1999)
  42. Azagra JS, "Laparoscopic anatomical(hepatic)left lateral segmentectomy-technical aspects", Surg Endosc, 10, pp.758~761 (1996)
  43. Eckhauser FE, "Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma", Am Surg, 60, pp.466~471 (1994)
  44. Wheeler PG, "Non-operative arterial embolisation in primary liver tumours", Br Med J, 2, pp.242~244 (1979)
  45. Ault GT, "Selective management of hepatic adenomas", Am Surg, 62, pp.825~829 (1996)
  46. Edmondson HA, "Tumors of the liver and intrahepatic bile duct, In Atlas of Tumor Pathology, Fascicle 25", pp.19~29 (1958), Armed Forces Institute of Pathology
  47. "Terminology of nodular hepatocellular lesions: International Working Party", Hepatology, 22, pp.983~993 (1995)
  48. Craig JR, "Tumors of the liver and intrahepatic bile ducts, In Atlas of Tumor Pathology, 2nd Series, Fascicle 26", pp.56~62 (1989), Armed Forces Institute of Pathology
  49. Wanless IR., "Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules", Hepatology, 11, pp.787~797 (1990)
  50. Wanless IR, "Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain : a new syndrome", Mod Pathol, 2, pp.456~462 (1989)
  51. Wanless IR, "On the pathogenesis of focal nodular hyperplasia of the liver", Hepatology, 5, pp.1194~1200 (1985)
  52. Vilgrain V, "Prevalence of hepatic hemangioma in patients with focal nodular hyperplasia : MR imaging analysis", Radiology, 229, pp.75~79 (2003)
  53. 강하얀, "국내에서 보고된 간내 국소결절과형성에 대한 임상 분석", 대한소화기학회지, 52(6), pp.376~383 (2008), 대한소화기학회
  54. Fukukura Y, "Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver", J Hepatol, 29, pp.470~475 (1998)
  55. Kondo F, "with emphasis on similar abnormal vasculatures to nodular regenerative hyperplasia and idiopathic portal hypertension", Pathol Res Pract, 194, pp.487~495 (1998)
  56. Sato Y, "Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver : a potential mechanism of central scar formation", Hum Pathol, 40, pp.181~188 (2009)
  57. Nguyen BN, "Focal nodular hyperplasia of the liver : a comprehensive pathologic study of 305 lesions and recognition of new histologic forms", Am J Surg Pathol, 23, pp.1441~1454 (1999)
  58. Brunt EM, "Infarction in focal nodular hyperplasia of the liver : a case report", Am J Clin Pathol, 95, pp.503~506 (1991)
  59. Lee MJ, "Focal nodular hyperplasia of the liver : MR findings in 35 proved cases", AJR Am J Roentgenol, 156, pp.317~320 (1991)
  60. Ishak KG, "Benign tumors of the liver", Med Clin North Am, 59, pp.995~1013 (1975)
  61. Quaia E, "The real capabilities of contrast-enhanced ultrasound in the characterization of solid focal liver lesions", Eur Radiol, 21, pp.457~462 (2011)
  62. Bartolozzi C, "Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver : comparison of power Doppler imaging and conventional color Doppler sonography", Eur Radiol, 7, pp.1410~1415 (1997)
  63. Carlson SK, "CT of focal nodular hyperplasia of the liver", AJR Am J Roentgenol, 174, pp.705~712 (2000)
  64. Buetow PC, "Focal nodular hyperplasia of the liver : radiologic-pathologic correlation", Radiographics, 16, pp.369~388 (1996)
  65. Irie H, "MR imaging of focal nodular hyperplasia of the liver : value of contrast-enhanced dynamic study", Radiat Med, 15, pp.29~35 (1997)

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