A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer
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high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needlefor MSI evaluation in patients with UR-PC. Methods: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) orEUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33)were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patientswho underwent EUS-FNB and those who underwent EUS-FNA. Results: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwentEUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained usingEUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariateanalysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
Abstract
high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needlefor MSI evaluation in patients with UR-PC. Methods: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) orEUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33)were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patientswho underwent EUS-FNB and those who underwent EUS-FNA. Results: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwentEUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained usingEUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariateanalysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation. Conclusions: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
참고문헌 (28)
- Siegel RL, "Cancer statistics, 2020", CA Cancer J Clin, 70, pp.7~30 (2020)
- Stathis A, "Advanced pancreatic carcinoma : current treatment and future challenges", Nat Rev Clin Oncol, 7, pp.163~172 (2010)
- Warsame R, "Treatment options for advanced pancreatic cancer : a review", Expert Rev Anticancer Ther, 12, pp.1327~1336 (2012)
- Fogel EL, "A multidisciplinary approach to pancreas cancer in 2016 : a review", Am J Gastroenterol, 112, pp.537~554 (2017)
- Sohal DPS, "Metastatic pancreatic cancer : ASCO guideline update", J Clin Oncol, 38, pp.3217~3230 (2020)
- Okusaka T, "Recent advances in chemotherapy for pancreatic cancer : evidence from Japan and recommendations in guidelines", J Gastroenterol, 55, pp.369~382 (2020)
- Williams DB, "Endoscopic ultrasound guided fine needle aspiration biopsy : a large single centre experience", Gut, 44, pp.720~726 (1999)
- Yoshinaga S, "Role of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)for diagnosis of solid pancreatic masses", Dig Endosc, 23(Suppl 1), pp.29~33 (2011)
- Uehara H, "Diagnostic accuracy of endoscopic ultrasound-guided fine needle aspiration for suspected pancreatic malignancy in relation to the size of lesions", J Gastroenterol Hepatol, 26, pp.1256~1261 (2011)
- Mukai S, "A retrospective histological comparison of EUS-guided fine-needle biopsy using a novel Franseen needle and a conventional end-cut type needle", Endosc Ultrasound, 8, pp.50~57 (2019)
- Sugiura R, "Prospective, multicenter, observational study of tissue acquisition through EUS-guided fine-needle biopsy using a 25G Franseen needle", Endosc Ultrasound, 8, pp.321~328 (2019)
- Sugimoto M, "Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions", BMC Cancer, 20, pp.1094~ (2020)
- Hikichi T, "Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologists", J Gastroenterol, 44, pp.322~328 (2009)
- Suzuki R, "Prospective evaluation of the optimal number of 25-gauge needle passes for endoscopic ultrasound-guided fine-needle aspiration biopsy of solid pancreatic lesions in the absence of an onsite cytopathologist", Dig Endosc, 24, pp.452~456 (2012)
- Varadhachary GR, "Borderline resectable pancreatic cancer : definitions, management, and role of preoperative therapy", Ann Surg Oncol, 13, pp.1035~1046 (2006)
- Japan Pancreas Society, "General rules for the study of pancreatic cancer" (2016), Kanehara & Co., Ltd
- Yamamoto H, "Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability", Cancer Res, 61, pp.3139~3144 (2001)
- Murphy KM, "Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers", J Mol Diagn, 8, pp.305~311 (2006)
- Kurata K, "Microsatellite instability in Japanese female patients with triple-negative breast cancer", Breast Cancer, 27, pp.490~498 (2020)
- Bando H, "Utility of the quasi-monomorphic variation range in unresectable metastatic colorectal cancer patients", Cancer Sci, 109, pp.3411~3415 (2018)
- Patil DT, "A five-marker panel in a multiplex PCR accurately detects microsatellite instability-high colorectal tumors without control DNA", Diagn Mol Pathol, 21, pp.127~133 (2012)
- Kanda Y, "Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics", Bone Marrow Transplant, 48, pp.452~458 (2013)
- Polkowski M, "Technical aspects of endoscopic ultrasound(EUS)-guided sampling in gastroenterology : European Society of Gastrointestinal Endoscopy(ESGE)Technical Guideline-March 2017", Endoscopy, 49, pp.989~1006 (2017)
- Le DT, "Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade", Science, 357, pp.409~413 (2017)
- Luchini C, "Microsatellite instability", mismatch repair deficiency in pancreatic cancers : the same or different?, 2021, pp.70, 1809~1811
- Singhi AD, "Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers", Gastroenterology, 156, pp.2242~2253 (2019)
- Kamatham S, "Circulating tumor DNA-based detection of microsatellite instability and response to immunotherapy in pancreatic cancer", Front Pharmacol, 11, pp.23~ (2020)
- Obayashi M, "Pancreatic undifferentiated carcinoma with osteoclast-like giant cells curatively resected after pembrolizumab therapy for lung metastases : a case report", BMC Gastroenterol, 20, pp.220~ (2020)