대장게실의 병태 생리
Pathophysiology of Colon Diverticulum
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초록
게실 질환은 임상에서 비교적 흔하게 보는 질병이지만 과거 수십 년간의 수많은 연구에도 불구하고 그 병태 생리는 아직까지 불분명하다. 또한 식이습관 및 생활형태의 변화에 따라 질병의 특성도 변화하고 있다. 증상 호전에 중점을 두는 현대의 치료 경향과 부합하여 새로이 제시되고 있는 염증 혹은 장내세균, 신경전달물질 등의 기전은 항염증제나 생균제 등 게실 치료 영역의 확대를 예측하게 한다. 임상의로서 변화하고 있는 질병의 특성과 병태생리의 이론을 숙지하여 다양한 모습의 게실 질환을 올바르게 진단하고 근거에 입각한 효과적인 치료 및 재발의 예방에 노력해야 한다.
Abstract
Although the pathogenesis of diverticulum remains unclear, traditionally it has been thought to result from structural abnormalities of the colonic wall, deficiencies of dietary fiber, or disordered intestinal motility. More recently, new pathophysiologic factors including inflammation, gut flora, neurotransmitters, visceral hypersensitivity, and chemical mediators are proposed, and their mechanism of interactions in developing diverticulum is quite complex and currently poorly understood. Future studies are needed to find out the multifaceted pathogenesis of diverticulum, ultimately for the treatment and prevention of disease.
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