미만성 거대B세포 항암치료 중 유발된 주기적 저칼륨성 마비 1예
Glucocorticoid Triggers an Attack of Periodic Hypokalemic Paralysis during Treatment for Diffuse Large B-cell Lymphoma
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Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-celllymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, andhis serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolonehad provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should beadministered with caution, particularly in patients with periodic paralysis.
Abstract
Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-celllymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, andhis serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolonehad provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should beadministered with caution, particularly in patients with periodic paralysis.
참고문헌 (10)
- Finsterer J, "Primary periodic paralyses", Acta Neurol Scand, 117, pp.145~158 (2008)
- Fontaine B, "Hypokalemic periodic paralysis: a model for a clinical and research approach to a rare disorder", Neurotherapeutics, 4, pp.225~232 (2007)
- Wongraoprasert S, "Thyrotoxic periodic paralysis induced by pulse methylprednisolone", Intern Med, 46, pp.1431~1433 (2007)
- Sternberg D, "GeneReviews R" (2002), University of Washington
- Streeten DH, "Use of corticotropin- induced potassium changes in the diagnosis of both hypo- and hyperkalemic periodic paralysis", Eur Neurol, 33, pp.103~108 (1993)
- Brillon DJ, "Effect of cortisol on energy expenditure and amino acid metabolism in humans", Am J Physiol, 268, pp.E501~513 (1995)
- Tassone H, "The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature", J Emerg Med, 26, pp.157~161 (2004)
- Ikeda K, "Acetazolamide- induced muscle weakness in hypokalemic periodic paralysis", Intern Med, 41, pp.743~745 (2002)
- Arzel-Hezode M, "Glucocorticoids may trigger attacks in several types of periodic paralysis", Neuromuscul Disord, 19, pp.217~219 (2009)
- Miyashita Y, "Ventricular fibrillation due to severe hypokalemia induced by steroid treatment in a patient with thyrotoxic periodic paralysis", Intern Med, 45, pp.11~13 (2006)