고인슐린혈증에 의해 유발된 저칼륨혈증 주기성 마비 1예
A case of hypokalemic perodic paralysis induced by hyperinsulinemia
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초록
본 저자들은 유전성 혹은 갑상선 중독증이 아닌 고인슐린혈증에 의한 저칼륨혈증성 주기성 마비로 내원한 39세 남자 환자를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Hypokalemia periodic paralysis, a clinical syndrome characterised by systemic weakness and low serum potassium, is a rare but treatable cause of acute weakness. Attacks of flaccid paralysis can be associated with hypokalemia triggered by insulin. Insulin reduce the conductance of the inward rectifier K+ channel for outward-flowing currents. Therefore, insulin potentiates depolarization of hypokalmeic periodic paralysis. We have experienced a case of hypokalemic periodic paralysis induced by hyperinsulinemia in 38-year old man, with complaint of intermittent paralysis of extremities. On admission, serum K+ was 2.1 mEq/L. He was no family history of muscle weakness. Thyroid function was normal. Serum levels of aldosterone, renin and cortisol were normal. Random plasma glucose level was 129 mg/dL and serum insulin was 131 uIU/mL. Shortly after intravenous supplementation of potassium, muscle weakness was improved. Oral glucose tolerance test revealed impaired glucose tolerance and hyperresponse of insulin and phosphate.(Korean J Med 68:692-696, 2005)
참고문헌 (17)
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