저칼륨증 없이 나타난 갑상샘중독주기마비 1예
Throtoxic Periodic Paralysis without Hypokalemia
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Thyrotoxic periodic paralysis (PP) is the most common acquired form of PP in Asian populations, and its cardinal and biochemical abnormality is hypokalemia. We describe a 39-year-old man who had acute bilateral limb motor weakness and paresthesia, and showed normokalemia during attack. Thyroid studies showed subclinical thyrotoxic Goiter. Control of the hyperthyroidism nearly eliminated his PP. Regardless of normokalemia, our patient might be a case of hypokalemic PP because of improvement from anti-thyroid medication.
Abstract
Thyrotoxic periodic paralysis (PP) is the most common acquired form of PP in Asian populations, and its cardinal and biochemical abnormality is hypokalemia. We describe a 39-year-old man who had acute bilateral limb motor weakness and paresthesia, and showed normokalemia during attack. Thyroid studies showed subclinical thyrotoxic Goiter. Control of the hyperthyroidism nearly eliminated his PP. Regardless of normokalemia, our patient might be a case of hypokalemic PP because of improvement from anti-thyroid medication.
참고문헌 (10)
- Ptacek LJ, "Ion channel disorders of muscle. In:Karpati G, Hilton-Jones D, Griggs RC, eds. Disorders ofvoluntary muscle", pp.604~635 (2001), Cambridge University Press
- Ober KP, "Thyrotoxic periodic paralysis in the United States:Report of 7 cases and review of the literature", Medicine, 71, pp.109~120 (1992)
- Vicart S., "New mutations ofSCN4A cause a potassium-sensitive normokalemic periodicparalysis", Neurology, 63, pp.2120~2127 (2004)
- González-Treviño O., "Normokalemic thyrotoxicperiodic paralysis: a new therapeutic strategy", Thyroid, 9, pp.61~63 (1999)
- Wu CC, "An unrecognized causeof paralysis in ED: thyrotoxic normokalemic periodic paralysis", Am J Emerg Med, 21, pp.71~73 (2003)
- McManis PG, "The exercise test inperiodic paralysis", Muscle Nerve, 9, pp.704~710 (1986)
- Tsuan-Shih Yu, "Potassuim chloride supplementation alone may not improvehypokalemia in thyrotoxic hypokalemic periodic paralysis", J Emerg Med, 32, pp.263~265 (2007)
- Sterns RH, "Internal potassiumbalance and the control of the plasma potassium concentration", Medicine, 60, pp.339~354 (1981)
- Kuwabara S., "Axonal hyperpolarizationassociated with acute hypokalemia: multiple excitabilitymeasurements as indicators of the membrane potential ofhuman axons", Muscle Nerve, 26, pp.283~287 (2002)
- Inshasi JS, "Dysfunctionof sensory nerves during attacks of hypokalemic periodicparalysis", Neuromuscular Disord, 9, pp.227~231 (1999)