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헬리코박터 파일로리 감염과 소화기 질환

Helicobacter Pylori Infection and Related Gastrointestinal Diseases

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주제분류내과학

초록

H. pylori는 가장 흔한 세균성 감염균 중 하나로 다양한 소화기 질환을 일으키지만 여전히 인류가 극복하지 못한 감염균이다. 만성 위염과 소화성 궤양, 위 변연부 B세포 림프종및 위암 등의 소화기 질환과의 연관성은 명확해 보이지만, 기능성 소화불량, 위식도역류질환, 바렛식도 및 식도 선암과의관계는 추가적인 연구가 필요하다(Fig. 1). H. pylori 독성인자의 유전적 다양성과 숙주요인, 기타 환경인자들의 다양한 반응에 따라 질병의 발생여부와 임상경과가 결정되는 것으로추측된다. 우리나라는 위암 발병률이 가장 높은 국가 중에 하나이며 국내 H. pylori 제균치료 성적 역시 감소추세를 보이고 있어, 최선의 제균치료 약제를 개발하고 H. pylori 감염을예방하는 것이 필요하다.

Abstract

Helicobacter pylori is among the most common bacterial pathogens, but it has not yet been conquered. It is related to various gastrointestinal diseases, including chronic gastritis, peptic ulcer, gastric marginal zone B cell lymphoma, and gastric cancer. The association between Helicobacter pylori infection and functional dyspepsia or gastroesophageal reflux disease is not clear. Numerous factors determine disease course and outcome, such as bacterial virulence, genotype, host immunity, and environmental factors. The eradication of Helicobacter pylori in associated gastrointestinal diseases is important for the treatment and prevention of recurrent or severe outcomes, especially in Korea where gastric cancer is prevalent.

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