헬리코박터 파일로리 감염의 진단과 치료: 국내 및 국외의 진료 지침
Diagnosis and Treatment of Helicobacter Pylori Infection: Korean and Overseas Guidelines
1
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
2009년 H. pylori 진단 및 치료에 대한 개정된 국내 진료지침이 도출된 지 4년만에 새로운 개정안이 발표되었다. 이번 진료지침에서는 위암의 전구 병변으로 인정되고 있는 위축성 위염 및 장상피 화생에서도 제균 치료의 필요성이 일부언급되었고, 제균 치료의 방법으로 증가하는 clarithromycin 의 내성률을 고려하여 bismuth 포함 사제 요법을 대체 가능한 일차 치료 요법으로 제시하였다. 또한, 제균 치료 실패 시선택할 수 있는 대안으로 순차 치료, 동시 치료 등의 요법을추가하였다. 최근 증가하는 항생제 내성률을 고려하였을 때, 이차 치료에도 불구하고 제균이 되지 않은 경우 국외의 진료지침에서는 CYP2C19 다형성 및 항생제 내성 검사 등을통한 맞춤형 치료를 시도하고 있으며, 국내에서도 이에 대한적극적인 연구가 필요할 것으로 생각된다.
Abstract
The Korean College of Helicobacter and Upper Gastrointestinal Research proposed revised guidelines for the diagnosis and treatment of Helicobacter pylori infection in 2013. These new guidelines were developed using an adaptation process, and addressed the revised recommendations especially in the changes of indication and treatment of H. pylori infection in Korea. They included 19 statements: 11 on the indications for tests and treatment, four for the diagnosis, and four for the treatment. A critical difference between the new and previous guidelines was that the proposed treatment regimen was more detailed, in consideration of the increasing resistance to antibiotics in Korea. Although clarithromycin-containing triple therapy was proposed as the first-line treatment option, per the previous guidelines, a bismuth-based quadruple regimen was also proposed as an effective alternative. In the case of treatment failure following bismuth quadruple therapy, second-line treatment should be based on two or more antibiotics that had not been used previously. Several overseas guidelines – from America, Europe, Canada, Japan, and the Asia-Pacific region – have been published concerning H. pylori infection; they indicate regional differences in epidemiology, antibiotic susceptibility, and national health insurance systems. This review compares the guidelines for H. pylori infection among these regions.
참고문헌 (98)
- Korean H, "Diagnosis and treatment of Helicobacter pylori infection in Korea", Korean J Gastroenterol, 32, pp.275~289 (1998)
- Yim JY, "Seroprevalence of Helicobacter pylori in South Korea", Helicobacter, 12, pp.333~340 (2007)
- Niv Y, "H pylori recurrence after successful eradication", World J Gastroenterol, 14, pp.1477~1478 (2008)
- Kim MS, "Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea", Helicobacter, 18, pp.135~142 (2013)
- Aesun Shin, "Gastric Cancer Epidemiology in Korea", Journal of Gastric Cancer, 11(3), pp.135~140 (2011), 대한위암학회
- Chang WK, "Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study", J Gastroenterol, 36, pp.816~822 (2001)
- 조수정, "Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea", Gut and Liver, 4(4), pp.466~474 (2010), 거트앤리버 발행위원회
- Lee SA, "Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer", J Epidemiol, 13, pp.162~168 (2003)
- Shin A, "A nested case-control study of the association of Helicobacter pylori infection with gastric adenocarcinoma in Korea", Br J Cancer, 92, pp.1273~1275 (2005)
- Kim N, "Helicobacter pylori infection and development of gastric cancer in Korea: long-term follow-up", J Clin Gastroenterol, 42, pp.448~454 (2008)
- 김상균, "한국인 헬리코박터 파일로리 감염의 진단과 치료 임상 진료지침 개정안 2013", 대한소화기학회지, 62(1), pp.3~26 (2013), 대한소화기학회
- Fervers B, "Guideline adaptation: an appealing alternative to de novo guideline development", Ann Intern Med, 148, pp.563~565 (2008)
- 김나영, "헬리코박터 파일로리 감염의 진단 및 치료 가이드라인", 대한소화기학회지, 54(5), pp.269~278 (2009), 대한소화기학회
- Chey WD, "American College of Gastroenterology guideline on the management of Helicobacter pylori infection", Am J Gastroenterol, 102, pp.1808~1825 (2007)
- Malfertheiner P, "Management of Helicobacter pylori infection--the Maastricht IV", Florence Consensus Report, 2012, pp.61, 646~664
- Fock KM, "Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection", J Gastroenterol Hepatol, 24, pp.1587~1600 (2009)
- Asaka M, "Guidelines for the management of Helicobacter pylori infection in Japan: 2009revised edition", Helicobacter, 15, pp.1~20 (2010)
- Hunt R, "Canadian Helicobacter Study Group Consensus Conference: Update on the management of Helicobacter pylori--an evidence-based evaluation of six topics relevant to clinical outcomes in patients evaluated for H pylori infection", Can J Gastroenterol, 18, pp.547~554 (2004)
- Guyatt GH, "Grades of recommendation for antithrombotic agents:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)", Chest, 133(6 Suppl), pp.123S~131S (2008)
- Schünemann HJ, "Grading quality of evidence and strength of recommendations for diagnostic tests and strategies", BMJ, 336, pp.1106~1110 (2008)
- Leodolter A, "A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori-associated gastric or duodenal ulcer", Aliment Pharmacol Ther, 15, pp.1949~1958 (2001)
- Sharma VK, "Helicobacter pylori eradication is superior to ulcer healing with or without maintenance therapy to prevent further ulcer haemorrhage", Aliment Pharmacol Ther, 15, pp.1939~1947 (2001)
- Miwa H, "Recurrent peptic ulcers in patients following successful Helicobacter pylori eradication:a multicenter study of 4940 patients", Helicobacter, 9, pp.9~16 (2004)
- Wotherspoon AC, "Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori", Lancet, 342, pp.575~577 (1993)
- Bayerdörffer E, "Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group", Lancet, 345, pp.1591~1594 (1995)
- Uemura N, "Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer", Cancer Epidemiol Biomarkers Prev, 6, pp.639~642 (1997)
- Fukase K, "Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer:an open-label, randomised controlled trial", Lancet, 372, pp.392~397 (2008)
- Maehata Y, "Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer", Gastrointest Endosc, 75, pp.39~46 (2012)
- van Grieken NC, "Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication", Digestion, 69, pp.27~33 (2004)
- Lu B, "Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: a 3-year follow-up study", World J Gastroenterol, 11, pp.6518~6520 (2005)
- Salih BA, "A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology", Dig Dis Sci, 50, pp.1517~1522 (2005)
- Wang J, "Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication:a meta-analysis", Digestion, 83, pp.253~260 (2011)
- Rokkas T, "Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis", Eur J Gastroenterol Hepatol, 22, pp.1128~1133 (2010)
- Chang YW, "Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients", Int J Cancer, 101, pp.469~474 (2002)
- Shin CM, "Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer", J Clin Gastroenterol, 44, pp.e34~39 (2010)
- Lassen AT, "Helicobacter pylori test and eradicate versus prompt endoscopy for management of dyspeptic patients: 6.7 year follow up of a randomised trial", Gut, 53, pp.1758~1763 (2004)
- Arents NL, "Approach to treatment of dyspepsia in primary care: a randomized trial comparing “test-and-treat” with prompt endoscopy", Arch Intern Med, 163, pp.1606~1612 (2003)
- Duggan AE, "Clinical trial: a randomized trial of early endoscopy, Helicobacter pylori testing and empirical therapy for the management of dyspepsia in primary care", Aliment Pharmacol Ther, 29, pp.55~68 (2009)
- Mahadeva S, "Cost-effectiveness of and satisfaction with a Helicobacter pylori “test and treat” strategy compared with prompt endoscopy in young Asians with dyspepsia", Gut, 57, pp.1214~1220 (2008)
- Delaney B, "Initial management strategies for dyspepsia", Cochrane Database Syst Rev, pp.CD001961~ (2005)
- 정혜경, "기능성 소화불량증의 진단: 체계적인 문헌고찰", 대한소화기학회지, 55(5), pp.296~307 (2010), 대한소화기학회
- 신명희, "서울시 암 발생률의 10년간 추이: 1993-2002", 예방의학회지, 41(2), pp.92~99 (2008), 대한예방의학회
- Bai Y, "Alarm features and age for predicting upper gastrointestinal malignancy in Chinese patients with dyspepsia with high background prevalence of Helicobacter pylori infection and upper gastrointestinal malignancy:an endoscopic database review of 102,665 patients from 1996 to 2006", Gut, 59, pp.722~728 (2010)
- Froehlich F, "Helicobacter pylori eradication treatment does not benefit patients with nonulcer dyspepsia", Am J Gastroenterol, 96, pp.2329~2336 (2001)
- Blum AL, "Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group", N Engl J Med, 339, pp.1875~1881 (1998)
- Talley NJ, "Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia", N Engl J Med, 341, pp.1106~1111 (1999)
- McColl K, "Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia", N Engl J Med, 339, pp.1869~1874 (1998)
- Harvey RF, "Clinical trial: prolonged beneficial effect of Helicobacter pylori eradication on dyspepsia consultations - the Bristol Helicobacter Project", Aliment Pharmacol Ther, 32, pp.394~400 (2010)
- 윤병철, "기능성 소화불량증에서 Helicobacter pylori 감염의 치료", 대한내과학회지, 75(5), pp.492~495 (2008), 대한내과학회
- el-Omar EM, "Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease", Gastroenterology, 109, pp.681~691 (1995)
- Feldman M, "Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux", Am J Physiol, 277(6 Pt 1), pp.G1159~1164 (1999)
- Koike T, "Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion", Gut, 49, pp.330~334 (2001)
- Iijima K, "Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication", Gut, 46, pp.20~26 (2000)
- Qian B, "Effects of Helicobacter pylori eradication on gastroesophageal reflux disease", Helicobacter, 16, pp.255~265 (2011)
- Yaghoobi M, "Is there an increased risk of GERD after Helicobacter pylori eradication?:a meta-analysis", Am J Gastroenterol, 105, pp.1007~1014 (2010)
- Pilotto A, "Helicobacter pylori infection and the prevention of peptic ulcer with proton pump inhibitors in elderly subjects taking low-dose aspirin", Dig Liver Dis, 36, pp.666~670 (2004)
- Lanas A, "Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low-dose aspirin", Aliment Pharmacol Ther, 16, pp.779~786 (2002)
- Chan FK, "Effects of Helicobacter pylori infection on long-term risk of peptic ulcer bleeding in low-dose aspirin users", Gastroenterology, 144, pp.528~535 (2013)
- Chan FK, "Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial", Lancet, 359, pp.9~13 (2002)
- Labenz J, "Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients:a randomised, double blind, placebo controlled, clinical trial", Gut, 51, pp.329~335 (2002)
- Vergara M, "Meta-analysis:role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users", Aliment Pharmacol Ther, 21, pp.1411~1418 (2005)
- Lai KC, "Effect of treatment of Helicobacter pylori on the prevention of gastroduodenal ulcers in patients receiving long-term NSAIDs: a double-blind, placebo-controlled trial", Aliment Pharmacol Ther, 17, pp.799~805 (2003)
- de Leest HT, "Eradication of Helicobacter pylori does not reduce the incidence of gastroduodenal ulcers in patients on long-term NSAID treatment:double-blind, randomized, placebo-controlled trial", Helicobacter, 12, pp.477~485 (2007)
- Kurtoglu E, "Helicobacter pylori infection in patients with autoimmune thrombocytopenic purpura", World J Gastroenterol, 10, pp.2113~2115 (2004)
- Gisbert JP, "Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection -- a critical review", Aliment Pharmacol Ther, 20, pp.1001~1017 (2004)
- Laine L, "Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori", Ann Intern Med, 129, pp.547~550 (1998)
- Graham DY, "Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors", Am J Gastroenterol, 98, pp.1005~1009 (2003)
- Levine A, "Masking of 13C urea breath test by proton pump inhibitors is dependent on type of medication: comparison between omeprazole, pantoprazole, lansoprazole and esomeprazole", Aliment Pharmacol Ther, 20, pp.117~122 (2004)
- Choi J, "Prospective evaluation of a new stool antigen test for the detection of Helicobacter pylori, in comparison with histology, rapid urease test, (13)C-urea breath test, and serology", J Gastroenterol Hepatol, 26, pp.1053~1059 (2011)
- Gisbert JP, "Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review", Helicobacter, 9, pp.347~368 (2004)
- Gisbert JP, "Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection:a systematic review and meta-analysis", Am J Gastroenterol, 101, pp.1921~1930 (2006)
- Gatta L, "Effect of proton pump inhibitors and antacid therapy on 13C urea breath tests and stool test for Helicobacter pylori infection", Am J Gastroenterol, 99, pp.823~829 (2004)
- Kokkola A, "Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis:comparison of histology, 13C-urea breath test, and serology", Scand J Gastroenterol, 35, pp.138~141 (2000)
- Gisbert JP, "Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis", Am J Gastroenterol, 101, pp.848~863 (2006)
- Ricci C, "Diagnosis of Helicobacter pylori:invasive and non-invasive tests", Best Pract Res Clin Gastroenterol, 21, pp.299~313 (2007)
- Fallone CA, "Hematoxylin and eosin staining of gastric tissue for the detection of Helicobacter pylori", Helicobacter, 2, pp.32~35 (1997)
- MacOni G, "Is routine histological evaluation an accurate test for Helicobacter pylori infection?", Aliment Pharmacol Ther, 13, pp.327~331 (1999)
- el-Zimaity HM, "Accurate diagnosis of Helicobacter pylori with biopsy", Gastroenterol Clin North Am, 29, pp.863~869 (2000)
- Kim CG, "Biopsy site for detecting Helicobacter pylori infection in patients with gastric cancer", J Gastroenterol Hepatol, 24, pp.469~474 (2009)
- Satoh K, "Biopsy sites suitable for the diagnosis of Helicobacter pylori infection and the assessment of the extent of atrophic gastritis", Am J Gastroenterol, 93, pp.569~573 (1998)
- Perri F, "Helicobacter pylori antigen stool test and 13C-urea breath test in patients after eradication treatments", Am J Gastroenterol, 97, pp.2756~2762 (2002)
- Matthews GM, "13C-urea breath test: reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis", J Gastroenterol Hepatol, 20, pp.270~274 (2005)
- 권기태, "Helicobacter pylori 제균요법 전과 후에 시행한 Helicobacter pylori stool antigen의 진단적 가치", 대한소화기학회지, 44(4), pp.199~205 (2004), 대한소화기학회
- Lee JY, "Usefulness of PyloriTek test for Helicobacter pylori detection after eradication therapy", Korean J Gastroenterol, 35, pp.170~177 (2000)
- Lam SK, "Report of the 1997 Asia Pacific Consensus Conference on the management of Helicobacter pylori infection", J Gastroenterol Hepatol, 13, pp.1~12 (1998)
- Katelaris PH, "A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE Study", Gastroenterology, 123, pp.1763~1769 (2002)
- Kim BG, "Comparison of 7-day and 14-day proton pump inhibitor-containing triple therapy for Helicobacter pylori eradication: neither treatment duration provides acceptable eradication rate in Korea", Helicobacter, 12, pp.31~35 (2007)
- Fuccio L, "Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication", Ann Intern Med, 147, pp.553~562 (2007)
- Paoluzi P, "2-week triple therapy for Helicobacter pylori infection is better than 1-week in clinical practice: a large prospective single-center randomized study", Helicobacter, 11, pp.562~568 (2006)
- Lee JW, "Prevalence of primary and secondary antimicrobial resistance of Helicobacter pylori in Korea from 2003 through 2012", Helicobacter, 18, pp.206~214 (2013)
- Chung JW, "Second-line Helicobacter pylori eradication: a randomized comparison of 1-week or 2-week bismuth-containing quadruple therapy", Helicobacter, 16, pp.289~294 (2011)
- Lee BH, "Bismuth-containing quadruple therapy as second-line treatment for Helicobacter pylori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea", Helicobacter, 15 (2010)
- Gisbert JP, "Sequential therapy for Helicobacter pylori eradication:a critical review", J Clin Gastroenterol, 44, pp.313~325 (2010)
- De Francesco V, "Clarithromycinresistant genotypes and eradication of Helicobacter pylori", Ann Intern Med, 144, pp.94~100 (2006)
- Kim SY, "Comparative study of Helicobacter pylori eradication rates with 5-day quadruple “concomitant” therapy and 7-day standard triple therapy", J Clin Gastroenterol, 47, pp.21~24 (2013)
- Lim JH, "Clinical outcomes of twoweek sequential and concomitant therapies for Helicobacter pylori eradication: a randomized pilot study", Helicobacter, 18, pp.180~186 (2013)
- 이선영, "헬리코박터 치료의 새로운 가이드라인: 한국과 일본의 비교", 대한소화기학회지, 63(3), pp.151~157 (2014), 대한소화기학회
- Lee SY, "Current progress toward eradicating Helicobacter pylori in East Asian countries: differences in the 2013 revised guidelines between China, Japan, and South Korea", World J Gastroenterol, 20, pp.1493~1502 (2014)
