본문 바로가기
KERD
논문KCI 등재

호흡기 질환에서의 중간엽 줄기 세포의 치료

Mesenchymal Stem Cell Therapy in Pulmonary Disease

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

중간엽 줄기 세포가 일상적인 임상 진료에 이용되기에는넘어야 할 장벽들이 아직 많다. 여러 가지 장기 세포로 분화하는 능력의 발견은 향후 장기 이식을 대체할 수 있으리라는장밋빛 미래도 기대하게 하였다. 그러나 투여한 중간엽 줄기세포가 곧바로 상피 세포로 재생될 것이라는 예상과는 달리다소 회의적인 후속 연구들이 발표되면서 현재는 그 기대감이 많이 줄어든 것이 사실이다. 중간엽 줄기 세포의 경우 일반적으로 암 발생의 위험이 적은 것으로 알려져 있지만 장기적인 연구가 더 필요하며, 아직은 증상 완화만이 치료의 큰부분을 차지하는 난치성 폐 질환에서 보조적인 요법으로 고려해 볼 수 있다.

Abstract

Stem cells are undifferentiated cells that are clonal, self-renewing, and can differentiate into multiple cell types (known as potency). Among stem cells, there are embryonal stem cells, induced pluripotent stem cells, mesenchymal stem cells (MSCs), and hematopoietic stem cells. MSCs are fibroblast-like non-hematopoietic stem cells that can differentiate into various tissue types, including bone, muscle, liver, lung, and cartilage. MSCs can be isolated from bone marrow, adipose tissue, placenta, or umbilical cord blood, among other tissues. MSCs are adherent under tissue culture conditions and express several cell surface markers, including CD105, CD73, and CD90. However, MSCs show negative expression for CD45, CD34, CD14, CD11b, CD79α, CD19, and HLA-DR. This article aims to explain the current definition of MSCs, describe therapies for which MSCs may be used, and review recent lung disease clinical trials.

참고문헌 (29)

  1. Friedenstein AJ, "Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues", Transplantation, 6, pp.230~247 (1968)
  2. Yang J, "Cell-based therapy in lung regenerative medicine", Regen Med Res, 2, pp.7~ (2014)
  3. Kolios G, "Introduction to stem cells and regenerative medicine", Respiration, 85, pp.3~10 (2013)
  4. Kim YI, "Cell Biological Characteristics of Adult Stem Cells", J Korean Med Assoc, 48, pp.993~1002 (2005)
  5. Dominici M, "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement", Cytotherapy, 8, pp.315~317 (2006)
  6. Weiss DJ, "An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases", Ann Am Thorac Soc, 12, pp.S79~S97 (2015)
  7. Sueblinvong V, "Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells", Am J Respir Crit Care Med, 177, pp.701~711 (2008)
  8. Mendez JJ, "Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds", Tissue Eng Part A, 20, pp.1735~1746 (2014)
  9. De Paepe ME, "Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells", Am J Pathol, 178, pp.1329~1339 (2011)
  10. Loi R, "Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells", Am J Respir Crit Care Med, 173, pp.171~179 (2006)
  11. Weiss DJ, "Stem cells and cell therapies in lung biology and lung diseases", Proc Am Thorac Soc, 8, pp.223~272 (2011)
  12. Schweitzer KS, "Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking", Am J Respir Crit Care Med, 183, pp.215~225 (2011)
  13. Prockop DJ, "Repair of tissues by adult stem", progenitor cells (MSCs): controversies, myths, and changing paradigms, 2009, pp.17, 939~946
  14. Weiss DJ, "Concise review: current status of stem cells and regenerative medicine in lung biology and diseases", Stem Cells, 32, pp.16~25 (2014)
  15. Stabler CT, "Mesenchymal stem cells for therapeutic applications in pulmonary medicine", Br Med Bull, 115, pp.45~56 (2015)
  16. Rehman J, "Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells", Circulation, 109, pp.1292~1298 (2004)
  17. Le Blanc K, "Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells", Lancet, 363, pp.1439~1441 (2004)
  18. Keating A, "Mesenchymal stromal cells: new directions", Cell Stem Cell, 10, pp.709~716 (2012)
  19. Prockop DJ, "Medical therapies with adult stem", pro-genitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations, 2012, pp.113, 1460~1469
  20. Vestbo J, "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary", Am J Respir Crit Care Med, 187, pp.347~365 (2013)
  21. Ribeiro-Paes JT, "Unicentric study of cell therapy in chronic obstructive pulmonary disease", pulmonary emphysema, 2011, pp.6, 63~71
  22. Weiss DJ, "A placebo-controlled, randomized trial of mesenchymal stem cells in COPD", Chest, 143, pp.1590~1598 (2013)
  23. Antunes MA, "Mesenchymal stem cell trials for pulmonary diseases", J Cell Biochem, 115, pp.1023~1032 (2014)
  24. ARDS Definition Task Force, "Acute respiratory distress syndrome: the Berlin Definition", JAMA, 307, pp.2526~2533 (2012)
  25. Zheng G, "Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study", Respir Res, 15, pp.39~ (2014)
  26. Raghu G, "An official ATS", ERS, ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management, pp.Am J Respir Crit Care Med, 2011[DOI]
  27. Raghu G, "An Official ATS", ERS, ALAT Clinical Practice Guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 Clinical Practice Guideline, pp.Am J Respir Crit Care Med, 2015[DOI]
  28. Tzouvelekis A, "A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis", J Transl Med, 11, pp.171~ (2013)
  29. Chambers DC, "A phase 1b study of placenta-derived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis", Respirology, 19, pp.1013~1018 (2014)

관련 논문AI추천

이 간행물의 다른 논문 (12건)