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임상적용을 위한 세포치료제로서의 성체 중간엽줄기세포

Adult Mesenchymal Stem Cells for Cell Therapy in Clinical Application

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초록

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

Abstract

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

참고문헌 (73)

  1. Prockop DJ, "Marrow stromal cells as stem cells for nonhematopoietic tissues", Science, 276(5309), pp.71~74 (1997)
  2. Friedenstein AJ, "Fibroblast precursors in normal and irradiated mouse hematopoietic organs", Exp Hematol, 4(5), pp.267~274 (1976)
  3. Friedenstein AJ, "The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells", Cell Tissue Kinet, 3(4), pp.393~403 (1970)
  4. Piersma AH, "Characterization of fibroblastic stromal cells from murine bone marrow", Exp Hematol, 13(4), pp.237~243 (1985)
  5. Caplan AI, "Mesenchymal stem cells", J Orthop Res, 9(5), pp.641~650 (1991)
  6. Friedenstein AJ, "Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers", Cell Tissue Kinet, 20(3), pp.263~272 (1987)
  7. Keating A, "Effect of different promoters on expression of genes introduced into hematopoietic and marrow stromal cells by electroporation", Exp Hematol, 18(2), pp.99~102 (1990)
  8. Thomson JA, "Embryonic stem cell lines derived from human blastocysts", Science, 282(5391), pp.1145~1147 (1998)
  9. Shamblott MJ, "Derivation of pluripotent stem cells from cultured human primordial germ cells", Proc Natl Acad Sci U S A, 95(23), pp.13726~13731 (1998)
  10. Takahashi K, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", Cell, 131(5), pp.861~872 (2007)
  11. Yu J, "Induced pluripotent stem cell lines derived from human somatic cells", Science, 318(5858), pp.1917~1920 (2007)
  12. Park IH, "Reprogramming of human somatic cells to pluripotency with defined factors", Nature, 451(7175), pp.141~146 (2008)
  13. Zuk PA, "Multilineage cells from human adipose tissue: implications for cell-based therapies", Tissue Eng, 7(2), pp.211~228 (2001)
  14. Erices A, "Mesenchymal progenitor cells in human umbilical cord blood", Br J Haematol, 109(1), pp.235~242 (2000)
  15. Rosada C, "The human umbilical cord blood: a potential source for osteoblast progenitor cells", Calcif Tissue Int, 72(2), pp.135~142 (2003)
  16. Williams JT, "Cells isolated from adult human skeletal muscle capable of differentiating into multiple mesodermal phenotypes", Am Surg, 65(1), pp.22~26 (1999)
  17. Kuznetsov SA, "Circulating skeletal stem cells", J Cell Biol, 153(5), pp.1133~1140 (2001)
  18. De Bari C, "Multipotent mesenchymal stem cells from adult human synovial membrane", Arthritis Rheum, 44(8), pp.1928~1942 (2001)
  19. In 't Anker PS, "Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation", Blood, 102(4), pp.1548~1549 (2003)
  20. Gronthos S, "Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo", Proc Natl Acad Sci U S A, 97(25), pp.13625~13630 (2000)
  21. Kuznetsov SA, "Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo", J Bone Miner Res, 12(9), pp.1335~1347 (1997)
  22. Pittenger MF, "Multilineage potential of adult human mesenchymal stem cells", Science, 284(5411), pp.143~147 (1999)
  23. Honczarenko M, "Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors", Stem Cells, 24(4), pp.1030~1041 (2006)
  24. Caplan AI, "The mesengenic process", Clin Plast Surg, 21(3), pp.429~435 (1994)
  25. Dominici M, "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement", Cytotherapy, 8(4), pp.315~317 (2006)
  26. Song IH, "In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo", J Orthop Res, 27(7), pp.916~921 (2009)
  27. Dennis JE, "Osteogenesis in marrow-derived mesenchymal cell porous ceramic composites transplanted subcutaneously: effect of fibronectin and laminin on cell retention and rate of osteogenic expression", Cell Transplant, 1(1), pp.23~32 (1992)
  28. Quarto R, "Repair of large bone defects with the use of autologous bone marrow stromal cells", N Engl J Med, 344(5), pp.385~386 (2001)
  29. Marcacci M, "Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study", Tissue Eng, 13(5), pp.947~955 (2007)
  30. Horwitz EM, "Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone", Proc Natl Acad Sci U S A, 99(13), pp.8932~8937 (2002)
  31. Horwitz EM, "Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta", Nat Med, 5(3), pp.309~313 (1999)
  32. Swieszkowski W, "Repair and regeneration of osteochondral defects in the articular joints", Biomol Eng, 24(5), pp.489~495 (2007)
  33. Chang F, "Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells", J Orthop Res, 26(1), pp.18~26 (2008)
  34. Yan H, "Repair of full-thickness cartilage defects with cells of different origin in a rabbit model", Arthroscopy, 23(2), pp.178~187 (2007)
  35. Wakitani S, "Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports", Cell Transplant, 13(5), pp.595~600 (2004)
  36. Wakitani S, "Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees", J Tissue Eng Regen Med, 1(1), pp.74~79 (2007)
  37. Kuroda R, "Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells", Osteoarthritis Cartilage, 15(2), pp.226~231 (2007)
  38. Makino S, "Cardiomyocytes can be generated from marrow stromal cells in vitro", J Clin Invest, 103(5), pp.697~705 (1999)
  39. Stamm C, "Autologous bone-marrow stem-cell transplantation for myocardial regeneration", Lancet, 361(9351), pp.45~46 (2003)
  40. Meyer GP, "Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial", Circulation, 113(10), pp.1287~1294 (2006)
  41. Wollert KC, "Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial", Lancet, 364(9429), pp.141~148 (2004)
  42. Fuchs S, "Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study", J Am Coll Cardiol, 41(10), pp.1721~1714 (2003)
  43. Chen SL, "Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction", Am J Cardiol, 94(1), pp.92~95 (2004)
  44. Lee JH, "Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation", Exp Cell Res, 307(1), pp.174~182 (2005)
  45. Xu M, "In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function", J Mol Cell Cardiol, 42(2), pp.441~448 (2007)
  46. Nagaya N, "Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy", Circulation, 112(8), pp.1128~1135 (2005)
  47. Araki T, "Brain electric activity for active inhibition of auditory irrelevant information", Neurosci Lett, 374(1), pp.11~16 (2005)
  48. Wang XJ, "The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases", Biochem Biophys Res Commun, 359(2), pp.189~193 (2007)
  49. Burt RK, "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases", JAMA, 299(8), pp.925~936 (2008)
  50. Kopen GC, "Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains", Proc Natl Acad Sci U S A, 96(19), pp.10711~10716 (1999)
  51. Redmond DE Jr, "Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells", Proc Natl Acad Sci U S A, 104(29), pp.12175~12180 (2007)
  52. Yasuhara T, "Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease", J Neurosci, 26(48), pp.12497~12511 (2006)
  53. Roberts TJ, "Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease", Neuroscience, 139(4), pp.1187~1199 (2006)
  54. Lee ST, "Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model", Neurosci Res, 52(3), pp.243~249 (2005)
  55. Tuszynski MH, "A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease", Nat Med, 11(5), pp.551~555 (2005)
  56. Copray S, "Olig2 overexpression induces the in vitro differentiation of neural stem cells into mature oligodendrocytes", Stem Cells, 24(4), pp.1001~1010 (2006)
  57. Karimi-Abdolrezaee S, "Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury", J Neurosci, 26(13), pp.3377~3389 (2006)
  58. Iwanami A, "Transplantation of human neural stem cells for spinal cord injury in primates", J Neurosci Res, 80(2), pp.182~190 (2005)
  59. Cao Q, "Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells", J Neurosci, 25(30), pp.6947~6957 (2005)
  60. Chu K, "Combined treatment of vascular endothelial growth factor and human neural stem cells in experimental focal cerebral ischemia", Neurosci Res, 53(4), pp.384~390 (2005)
  61. Jeong SW, "Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage", Stroke, 34(9), pp.2258~2263 (2003)
  62. Chen J, "Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat", J Neurosci Res, 73(6), pp.778~786 (2003)
  63. Javazon EH, "Mesenchymal stem cells: paradoxes of passaging", Exp Hematol, 32(5), pp.414~425 (2004)
  64. Di Nicola M, "Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli", Blood, 99(10), pp.3838~3843 (2002)
  65. Bartholomew A, "Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo", Exp Hematol, 30(1), pp.42~48 (2002)
  66. Krampera M, "Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide", Blood, 101(9), pp.3722~3729 (2003)
  67. Le Blanc K, "Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex", Scand J Immunol, 57(1), pp.11~20 (2003)
  68. Corcione A, "Human mesenchymal stem cells modulate B-cell functions", Blood, 107(1), pp.367~372 (2006)
  69. Jiang XX, "Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells", Blood, 105(10), pp.4120~4126 (2005)
  70. Beyth S, "Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness", Blood, 105(5), pp.2214~2219 (2005)
  71. Aggarwal S, "Human mesenchymal stem cells modulate allogeneic immune cell responses", Blood, 105(4), pp.1815~1822 (2005)
  72. Zappia E, "Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy", Blood, 106(5), pp.1755~1761 (2005)
  73. Lazarus HM, "Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients", Biol Blood Marrow Transplant, 11(5), pp.389~398 (2005)

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