알레르기성 기도 질환의 동물모델에서 줄기 세포 치료
Stem cell therapy in animal models of allergic airway diseases
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Allergic airway diseases are characterized by T-helper type 2 (Th2)-skewed eosinophilic infl ammation, mucus hypersecretion, and airway hyperresponsiveness. The excessive activation of Th2 cells due to insufficient suppression of regulatory T cells (Tregs) is thought to play a major role in the initiation and development of allergic airway disease. Several studies have shown that stem cells provide a signifi cant reduction in allergic airway infl ammation and improve lung function in animal models. The immunomodula- tory eff ects of stem cells in allergic airway disease may be mediated by the up-regulation of Tregs and increases in several soluble factors, such as prostaglandin E2, transforming growth factor-β, interleukin-10, and indoleamine 2, 3-dioxygenase. This review ex- amines the current understanding of the immunomodulatory properties of stem cells and its therapeutic implication in allergic air- way disease. Furthermore, we will discuss mechanisms by which stem cells inhibit allergic airway infl ammation via immunomodula- tion from a Th2- to a Th1-biased response.
Abstract
Allergic airway diseases are characterized by T-helper type 2 (Th2)-skewed eosinophilic infl ammation, mucus hypersecretion, and airway hyperresponsiveness. The excessive activation of Th2 cells due to insufficient suppression of regulatory T cells (Tregs) is thought to play a major role in the initiation and development of allergic airway disease. Several studies have shown that stem cells provide a signifi cant reduction in allergic airway infl ammation and improve lung function in animal models. The immunomodula- tory eff ects of stem cells in allergic airway disease may be mediated by the up-regulation of Tregs and increases in several soluble factors, such as prostaglandin E2, transforming growth factor-β, interleukin-10, and indoleamine 2, 3-dioxygenase. This review ex- amines the current understanding of the immunomodulatory properties of stem cells and its therapeutic implication in allergic air- way disease. Furthermore, we will discuss mechanisms by which stem cells inhibit allergic airway infl ammation via immunomodula- tion from a Th2- to a Th1-biased response.
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