카바페넴 내성 장내세균: 감염 관리를 위한 신속한 검사실 진단 및 감시 배양
Carbapenem-Resistant Enterobacteriaceae: Rapid Laboratory Diagnosis and Surveillance Culture for Infection Control
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Carbapenem-resistant Enterobacteriaceae (CRE) are increasing rapidly worldwide and in South Korea, which is a major problem for patient treatment and infection control. CRE is mainly due to carbapenem-hydrolyzing β-lactamase, which spreads through genetic mobile elements. Therefore, the rapid detection of carbapenemase-producing CRE (CP-CRE) and carrier surveillance are very important for infection control. Most clinical microbiology laboratories use automated real-time PCR methods for the rapid detection of CP-CRE; in some cases, additional accurate molecular tests are necessary. For the surveillance of risk groups, the complementary use of liquid culture and real-time PCR methods is important, taking into consideration their advantages and disadvantages. Furthermore, the expansion of surveillance targets is also necessary.
Abstract
Carbapenem-resistant Enterobacteriaceae (CRE) are increasing rapidly worldwide and in South Korea, which is a major problem for patient treatment and infection control. CRE is mainly due to carbapenem-hydrolyzing β-lactamase, which spreads through genetic mobile elements. Therefore, the rapid detection of carbapenemase-producing CRE (CP-CRE) and carrier surveillance are very important for infection control. Most clinical microbiology laboratories use automated real-time PCR methods for the rapid detection of CP-CRE; in some cases, additional accurate molecular tests are necessary. For the surveillance of risk groups, the complementary use of liquid culture and real-time PCR methods is important, taking into consideration their advantages and disadvantages. Furthermore, the expansion of surveillance targets is also necessary.
참고문헌 (10)
- Gupta N, "Carbapenem-resistant Enterobacteriaceae : epidemiology and prevention", Clin Infect Dis, 53, pp.60~67 (2011)
- Nordmann P, "Global spread of Carbapenemaseproducing Enterobacteriaceae", Emerg Infect Dis, 17, pp.1791~1798 (2011)
- 이효진, "Carbapenem-resistant Enterobacteriaceae: Prevalence and Risk Factors in a Single Community-Based Hospital in Korea", Infection and Chemotherapy, 48(3), pp.166~173 (2016), 대한감염학회
- Young Ah Kim, "Epidemiology and treatment of antimicrobialresistant gram-negative bacteria in Korea", The Korean Journal of Internal Medicine, 33(2), pp.247~255 (2018), 대한내과학회[DOI]
- Potter RF, "The rapid spread of carbapenem-resistant enterobacteriaceae", Drug Resist Updat, 29, pp.30~46 (2016)
- Falagas ME, "Risk factors of carbapenem-resistant Klebsiella pneumoniae infections : a matched case control study", J Antimicrob Chemother, 60, pp.1124~1130 (2007)
- Vardakas KZ, "Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit", J Infect, 70, pp.592~599 (2015)
- Iovleva A, "Carbapenem-resistant Enterobacteriaceae", Clin Lab Med, 37, pp.303~315 (2017)
- 이창섭, "Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens", Infection and Chemotherapy, 46(3), pp.149~164 (2014), 대한감염학회
- Tamma PD, "Comparing the outcomes of patients with carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae Bacteremia", Clin Infect Dis, 64, pp.257~264 (2017)