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신장 질환에서 생체표지자로서의 소변의 세포외 소포체의 역할

Urinary Extracellular Vesicles as Biomarkers of Kidney Disease

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초록

Extracellular vesicles (EVs) are membrane-bound vesicles produced and released into the extracellular fluid by cells under physiological and stressful conditions. They play a role as intracellular communicators by carrying and delivering biomolecules, such as proteins, lipids, or nucleic acids. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease, as they can originate from diverse cell types, including glomerular podocytes, tubular epithelial cells, or endothelial cells. Accumulating evidence has emphasized the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implications as a therapeutic option in significant kidney diseases. (Korean

Abstract

Extracellular vesicles (EVs) are membrane-bound vesicles produced and released into the extracellular fluid by cells under physiological and stressful conditions. They play a role as intracellular communicators by carrying and delivering biomolecules, such as proteins, lipids, or nucleic acids. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease, as they can originate from diverse cell types, including glomerular podocytes, tubular epithelial cells, or endothelial cells. Accumulating evidence has emphasized the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implications as a therapeutic option in significant kidney diseases. (Korean

참고문헌 (32)

  1. Camussi G, "Exosomes", microvesicles as a mechanism of cell-to-cell communication, 2010, pp.78, 838~848
  2. Krause M, "Exosomes as renal inductive signals in health and disease, and their application as diagnostic markers and therapeutic agents", Front Cell Dev Biol, 3, pp.65~ (2015)
  3. du Cheyron D, "Urinary measurement of Na+", H+ exchanger isoform 3(NHE3)protein as new marker of tubule injury in critically ill patients with ARF, 2003, pp.42, 497~506
  4. Zhang W, "Extracellular vesicles in diagnosis and therapy of kidney diseases", Am J Physiol Renal Physiol., 311, pp.F844~F851 (2016)
  5. Wolf P, "The nature and significance of platelet products in human plasma", Br J Haematol, 13, pp.269~288 (1967)
  6. van der Pol E, "Classification, functions, and clinical relevance of extracellular vesicles", Pharmacol Rev, 64, pp.676~705 (2012)
  7. Oosthuyzen W, "Quantification of human urinary exosomes by nanoparticle tracking analysis", J Physiol, 591, pp.5833~5842 (2013)
  8. Merchant ML, "Isolation and characterization of urinary extracellular vesicles : implications for biomarker discovery", Nat Rev Nephrol, 13, pp.731~749 (2017)
  9. Alvarez ML, "Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers", Kidney Int, 82, pp.1024~1032 (2012)
  10. Xu R, "Extracellular vesicle isolation and characterization : toward clinical application", J Clin Invest, 126, pp.1152~1162 (2016)
  11. Sun IO, "Urinary extracellular vesicles as biomarkers of kidney disease : from diagnostics to therapeutics", Diagnostics(Basel), 10, pp.311~ (2020)
  12. Sun IO, "Extracellular vesicles : a novel window into kidney function and disease", Curr Opin Nephrol Hypertens, 29, pp.613~619 (2020)
  13. Zhou H, "Urinary exosomal transcription factors, a new class of biomarkers for renal disease", Kidney Int, 74, pp.613~621 (2008)
  14. Panich T, "Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury", BMC Nephrol, 18, pp.10~ (2017)
  15. Sonoda H, "Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury", Am J Physiol Renal Physiol., 297, pp.F1006~F1016 (2009)
  16. Zhou H, "Urinary exosomal Wilms' tumor-1 as a potential biomarker for podocyte injury", Am J Physiol Renal Physiol., 305, pp.F553~F559 (2013)
  17. Moon PG, "Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy", Proteomics, 11, pp.2459~2475 (2011)
  18. Feng Y, "Urinary Exosomes and exosomal CCL2 mRNA as biomarkers of active histologic injury in IgA nephropathy", Am J Pathol, 188, pp.2542~2552 (2018)
  19. Sun H, "Urinary exosomes as a novel biomarker for evaluation of α-lipoic acid's protective effect in early diabetic nephropathy", J Clin Lab Anal., 31, pp.e22129~ (2017)
  20. Burger D, "Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury", J Am Soc Nephrol, 25, pp.1401~1407 (2014)
  21. Jia Y, "miRNAs in urine extracellular vesicles as predictors of early-stage diabetic nephropathy", J Diabetes Res, 2016, pp.7932765~ (2016)
  22. Kwon SH, "Differential expression of microRNAs in urinary extracellular vesicles obtained from hypertensive patients", Am J Kidney Dis, 68, pp.331~332 (2016)
  23. Kwon SH, "Elevated urinary podocytederived extracellular microvesicles in renovascular hypertensive patients", Nephrol Dial Transplant, 32, pp.800~807 (2017)
  24. Sun IO, "Loss of renal peritubular capillaries in hypertensive patients is detectable by urinary endothelial microparticle levels", Hypertension, 72, pp.1180~1188 (2018)
  25. Hogan MC, "Characterization of PKD protein-positive exosome-like vesicles", J Am Soc Nephrol, 20, pp.278~288 (2009)
  26. Hogan MC, "Identification of biomarkers for PKD1 using urinary exosomes", J Am Soc Nephrol, 26, pp.1661~1670 (2015)
  27. Heyer CM, "Predicted mutation strength of nontruncating PKD1 mutations aids genotypephenotype correlations in autosomal dominant polycystic kidney disease", J Am Soc Nephrol, 27, pp.2872~2884 (2016)
  28. Bruschi M, "Proteomic analysis of urinary microvesicles and exosomes in medullary sponge kidney disease and autosomal dominant polycystic kidney disease", Clin J Am Soc Nephrol, 14, pp.834~843 (2019)
  29. Alvarez S, "Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation", Transplant Proc, 45, pp.3719~3723 (2013)
  30. Park J, "Integrated kidney exosome analysis for the detection of kidney transplant rejection", ACS Nano, 11, pp.11041~11046 (2017)
  31. Bruno S, "Mesenchymal stem cell-derived microvesicles protect against acute tubular injury", J Am Soc Nephrol, 20, pp.1053~1067 (2009)
  32. Eirin A, "Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation", Kidney Int, 92, pp.114~124 (2017)

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