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Plasma Factor XIII Activity in Patients with Disseminated Intravascular Coagulation

최종락|송경순|이지혁|송재우
연세대학교의과대학 (Yonsei University College of Medicine)|2006.04|Yonsei Medical Journal|제47권 제2호|pp. 196-200

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참고문헌

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초록

The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n= 29), infection (n=25), inflammation (n=6), heart disease (n=3), thrombosis (n=2), injury (n=2), and other miscellaneous conditions (n=13). FXIII testing was performed using the CoaLinkTM FXIII Incorporation Assay Kit (PeopleBio Inc.). Among 80 patients who were suspected to have DIC based on clinical analysis, 46 (57.5%) fulfilled the overt DIC criteria (DIC score>=5) according to the International Society of Thrombosis and Haemostasis. FXIII levels in the plasma were significantly decreased in overt DIC compared to non-overt DIC patients (mean 75.1% and 199.7% respectively, p<0.0001). Interestingly, we found a significant inverse correlation between DIC scores and FXIII activity. In addition, FXIII activity significantly correlated with other hemostatic markers that included platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, and D-dimer. FXIII levels were significantly lower in patients with liver or renal dysfunction. In conclusion, FXIII cross-linking activity measurements may have differential diagnostic value as well as predictive value in patients who are suspected to have DIC.

Abstract

The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n= 29), infection (n=25), inflammation (n=6), heart disease (n=3), thrombosis (n=2), injury (n=2), and other miscellaneous conditions (n=13). FXIII testing was performed using the CoaLinkTM FXIII Incorporation Assay Kit (PeopleBio Inc.). Among 80 patients who were suspected to have DIC based on clinical analysis, 46 (57.5%) fulfilled the overt DIC criteria (DIC score>=5) according to the International Society of Thrombosis and Haemostasis. FXIII levels in the plasma were significantly decreased in overt DIC compared to non-overt DIC patients (mean 75.1% and 199.7% respectively, p<0.0001). Interestingly, we found a significant inverse correlation between DIC scores and FXIII activity. In addition, FXIII activity significantly correlated with other hemostatic markers that included platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, and D-dimer. FXIII levels were significantly lower in patients with liver or renal dysfunction. In conclusion, FXIII cross-linking activity measurements may have differential diagnostic value as well as predictive value in patients who are suspected to have DIC.

참고문헌 (16)

  1. "Electron microscopy and hydrodynamic properties of factor XIII subunits", pp.551~6
  2. "multifunctional cross-linking enzymes that stabilize tissues", pp.3071~7
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  4. "Factor XIII deficiency and postoperative hemorrhage after neurosurgical procedures", 54, pp.260~266 (2000)
  5. "Factor XIII deficiency: pathogenic mechanisms and clinical significance", 22, pp.419~425 (1996)
  6. "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation", 86, pp.1327~1330 (2001)
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  8. "Changes of factor XIII a and b subunit in patients with disseminated intravascular coagulation syndrome", 44, pp.355~361 (1996)
  9. "Disseminated intravascular coagulation", 341, pp.586~592 (1999)
  10. "Pathogenesis of disseminated intravascular coagulation in sepsis", pp.975~9
  11. "Cinical implications of a validated scoring system for disseminated intravascular coagulation", 32, pp.2548~2549 (2004)
  12. "-Successful treatment with antithrombin III concentrate and a concentrate containing FXIII and native von Willebrand factor", ab(rmal proteolysis), pp.21~7
  13. "Antiplasmin drugs and factor XIII concentrates in the treatment of a patient with acute promyelocytic leukemia", suga(w), pp.1479~82
  14. "Quantitative estimation of coagulation factors in liver disease The diagnostic and prognostic value of factor XIII", pp.646~56
  15. "A contribution to the pathology of acquired plasma factor XIII deficiency", pp.357~61
  16. "Rapid formation of large molecular weight alpha-polymers in cross-linked fibrin induced by high factor XIII concentrations Role of platelet factor XIII", pp.1459~65

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Evaluation of the Diagnostic Performance of Fibrin Monomer in Disseminated Intravascular Coagulation권의훈, 김선희, 김희진, 박경진대한진단검사의학회 · Annals of Laboratory Medicine2011 · 제31권 제3호Changes in Plasma Levels of Natural Anticoagulants in Disseminated Intravascular Coagulation: High Prognostic Value of Antithrombin and Protein C in Patients with Underlying Sepsis or Severe Infection김지은, 김현경, 최규태, 홍기호대한진단검사의학회 · Annals of Laboratory Medicine2014 · 제34권 제2호Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular CoagulationCheng-Hock Toh, Simon T. Abrams, Yasir Alhamdi대한진단검사의학회 · Annals of Laboratory Medicine2016 · 제36권 제6호Clinical Significance of von Willebrand Factor-Cleaving Protease (ADAMTS13) Deficiency in Patients with Sepsis-Induced Disseminated Intravascular Coagulation권희욱, 김영근, 이경아, 이종욱대한감염학회 · Infection and Chemotherapy2009 · 제41권 제2호Relationships of Coagulation Factor XIII Activity with Cell-Type and Stage of Non-Small Cell Lung Cancer신철, 강경호, 김제형, 서인범, 심재정, 유세화, 이상엽, 이승룡, 이승헌, 이은주, 인광호, 허규영연세대학교의과대학 · Yonsei Medical Journal2013 · 제54권 제6호Influence of Blood Coagulation Factors on Thromboelastographic Parameters in Healthy Adults구자윤, 김만진, 김승환, 김현경대한진단검사의학회 · Laboratory Medicine Online2022 · 제12권 제2호

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