Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation
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Systemically sustained thrombin generation in vivo is the hallmark of disseminated intravascular coagulation (DIC). Typically, this is in response to a progressing disease state that is associated with significant cellular injury. The etiology could be infectious or noninfectious, with the main pathophysiological mechanisms involving cross-activation among coagulation, innate immunity, and inflammatory responses. This leads to consumption of both pro- and anticoagulant factors as well as endothelial dysfunction and disrupted homeostasis at the blood vessel wall interface. In addition to the release of tissue plasminogen activator (tPA) and soluble thrombomodulin (sTM) following cellular activation and damage, respectively, there is the release of damage-associated molecular patterns (DAMPs) such as extracellular histones and cell-free DNA. Extracellular histones are increasingly recognized as significantly pathogenic in critical illnesses through direct cell toxicity, the promotion of thrombin generation, and the induction of neutrophil extracellular trap (NET) formation. Clinically, high circulating levels of histones and histone–DNA complexes are associated with multiorgan failure, DIC, and adverse patient outcomes. Their measurements as well as that of other DAMPs and molecular markers of thrombin generation are not yet applicable in the routine diagnostic laboratory. To provide a practical diagnostic tool for acute DIC, a composite scoring system using rapidly available coagulation tests is recommended by the International Society on Thrombosis and Haemostasis. Its usefulness and limitations are discussed alongside the advances and unanswered questions in DIC pathogenesis.
Abstract
Systemically sustained thrombin generation in vivo is the hallmark of disseminated intravascular coagulation (DIC). Typically, this is in response to a progressing disease state that is associated with significant cellular injury. The etiology could be infectious or noninfectious, with the main pathophysiological mechanisms involving cross-activation among coagulation, innate immunity, and inflammatory responses. This leads to consumption of both pro- and anticoagulant factors as well as endothelial dysfunction and disrupted homeostasis at the blood vessel wall interface. In addition to the release of tissue plasminogen activator (tPA) and soluble thrombomodulin (sTM) following cellular activation and damage, respectively, there is the release of damage-associated molecular patterns (DAMPs) such as extracellular histones and cell-free DNA. Extracellular histones are increasingly recognized as significantly pathogenic in critical illnesses through direct cell toxicity, the promotion of thrombin generation, and the induction of neutrophil extracellular trap (NET) formation. Clinically, high circulating levels of histones and histone–DNA complexes are associated with multiorgan failure, DIC, and adverse patient outcomes. Their measurements as well as that of other DAMPs and molecular markers of thrombin generation are not yet applicable in the routine diagnostic laboratory. To provide a practical diagnostic tool for acute DIC, a composite scoring system using rapidly available coagulation tests is recommended by the International Society on Thrombosis and Haemostasis. Its usefulness and limitations are discussed alongside the advances and unanswered questions in DIC pathogenesis.
참고문헌 (66)
- Crawley JT, "The central role of thrombin in hemostasis", J Thromb Haemost, 5(S1), pp.95~101 (2007)
- Taylor FB Jr, "Description of compensated and uncompensated disseminated intravascular coagulation (DIC) responses (non-overt and overt DIC) in baboon models of intravenous and intraperitoneal Escherichia coli sepsis and in the human model of endotoxemia: toward a better definition of DIC", Crit Care Med, 28(9S), pp.S12~S19 (2000)
- Taylor FB Jr, "Scientific Subcommittee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation", Thromb Haemost, 86, pp.1327~1330 (2001)
- Bakhtiari K, "Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation", Crit Care Med, 32, pp.2416~2421 (2004)
- Kjalke M, "Active site-inactivated factors VIIa, Xa, and IXa inhibit individual steps in a cell-based model of tissue factor-initiated coagulation", Thromb Haemost, 80, pp.578~584 (1998)
- Rezaie AR, "Regulation of the protein C anticoagulant and antiinflammatory pathways", Curr Med Chem, 17, pp.2059~2069 (2010)
- Levin EG, "Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells", J Clin Invest, 74, pp.1988~1995 (1984)
- Gelehrter TD, "Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells", J Clin Invest, 77, pp.165~169 (1986)
- Wang W, "A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor", J Biol Chem, 273, pp.27176~27181 (1998)
- Satta N, "Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide", J Immunol, 153, pp.3245~3255 (1994)
- Taylor FB Jr, "Anticoagulant and fibrinolytic activities are promoted, not retarded, in vivo after thrombin generation in the presence of a monoclonal antibody that inhibits activation of protein C", Blood, 79, pp.1720~1728 (1992)
- Aird WC, "Endothelium and haemostasis", Hamostaseologie, 35, pp.11~16 (2015)
- Monahan-Earley R, "Evolutionary origins of the blood vascular system and endothelium", J Thromb Haemost, 11(Sl), pp.46~66 (2013)
- Riewald M, "Activation of endothelial cell protease activated receptor 1 by the protein C pathway", Science, 296, pp.1880~1882 (2002)
- Abeyama K, "The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism", J Clin Invest, 115, pp.1267~1274 (2005)
- Moxon CA, "Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding", J Thromb Haemost, 13, pp.1653~1664 (2015)
- Moxon CA, "Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children", Blood, 122, pp.842~851 (2013)
- Turner L, "Severe malaria is associated with parasite binding to endothelial protein C receptor", Nature, 498, pp.502~505 (2013)
- Engelmann B, "Thrombosis as an intravascular effector of innate immunity", Nat Rev Immunol, 13, pp.34~45 (2013)
- Esmon CT, "Innate immunity and coagulation", J Thromb Haemost, 9(S1), pp.182~188 (2011)
- Ito T, "PAMPs and DAMPs as triggers for DIC", J Intensive Care, 2, pp.67~ (2014)
- Conway EM, "Reincarnation of ancient links between coagulation and complement", J Thromb Haemost, 13(S1), pp.S121~S132 (2015)
- Kim JE, "Circulating levels of DNA-histone complex and dsDNA are independent prognostic factors of disseminated intravascular coagulation", Thromb Res, 135, pp.1064~1069 (2015)
- Nakahara M, "Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism", PLoS One, 8, pp.e75961~ (2013)
- Abrams ST, "Circulating histones are mediators of trauma-associated lung injury", Am J Respir Crit Care Med, 187, pp.160~169 (2013)
- Alhamdi Y, "Circulating histone concentrations differentially affect the predominance of left or right ventricular dysfunction in critical illness", Crit Care Med, 44, pp.e278~e288 (2016)
- Fuchs TA, "Histones induce rapid and profound thrombocytopenia in mice", Blood, 118, pp.3708~3714 (2011)
- Longstaff C, "Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones", J Biol Chem, 288, pp.6946~6956 (2013)
- Martinod K, "Thrombosis: tangled up in NETs", Blood, 123, pp.2768~2776 (2014)
- Yamamichi S, "Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo", Biochem Biophys Res Commun, 409, pp.483~488 (2011)
- Semeraro F, "Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4", Blood, 118, pp.1952~1961 (2011)
- Ammollo CT, "Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation", J Thromb Haemost, 9, pp.1795~1803 (2011)
- Barranco-Medina S, "Histone H4 promotes prothrombin autoactivation", J Biol Chem, 288, pp.35749~35757 (2013)
- Alhamdi Y, "Circulating histones are major mediators of cardiac injury in patients with sepsis", Crit Care Med, 43, pp.2094~2103 (2015)
- Levi M, "Guidelines for the diagnosis and management of disseminated intravascular coagulation", Br J Haematol, 145, pp.24~33 (2009)
- Toh CH, "The scoring system of the Scientific and Standardisation Committee on Disseminated Intravascular Coagulation of the International Society on Thrombosis and Haemostasis: a 5-year overview", J Thromb Haemost, 5, pp.604~606 (2007)
- Gando S, "A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis", Crit Care, 17, pp.R111~ (2013)
- Wada H, "Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis and of the Japanese Ministry of Health and Welfare for overt DIC", Am J Hematol, 74, pp.17~22 (2003)
- Toh CH, "Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation", Blood Coagul Fibrinolysis, 16, pp.69~74 (2005)
- Kinasewitz GT, "Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis", Crit Care Med, 33, pp.2214~2221 (2005)
- Dhainaut JF, "Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure", Crit Care Med, 33, pp.341~348 (2005)
- Levi M, "DIC: which laboratory tests are most useful", Blood Rev, 25, pp.33~37 (2011)
- Kitchen S, "Lipid composition of seven APTT reagents in relation to heparin sensitivity", Br J Haematol, 106, pp.801~808 (1999)
- Wada H, "Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines", J Thromb Haemost, 11, pp.761~767 (2013)
- Kim HK, "Application of the international normalized ratio in the scoring system for disseminated intravascular coagulation", J Thromb Haemost, 8, pp.1116~1118 (2010)
- Thiele T, "Thrombocytopenia in the intensive care unit-diagnostic approach and management", Semin Hematol, 50, pp.239~250 (2013)
- Kim SY, "Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation.", Am J Clin Pathol, 134, pp.634~647 (2010)
- Yaguchi A, "Platelet function in sepsis", J Thromb Haemost, 2, pp.2096~2102 (2004)
- Hyun J, "Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation", Thromb Res, 124, pp.75~79 (2009)
- Ono T, "Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure", Blood, 107, pp.528~534 (2006)
- Alhamdi Y, "Histone-associated thrombocytopenia in patients who are critically ill", JAMA, 315, pp.817~819 (2016)
- Caudrillier A, "Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury", J Clin Invest, 122, pp.2661~2671 (2012)
- Goel R, "Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality", Blood, 125, pp.1470~1476 (2015)
- Yu M, "Screening tests of disseminated intravascular coagulation: guidelines for rapid and specific laboratory diagnosis", Crit Care Med, 28, pp.1777~1780 (2000)
- Mackie IJ, "Guidelines on fibrinogen assays", Br J Haematol, 121, pp.396~404 (2003)
- Toh JM, "The clinical utility of fibrin-related biomarkers in sepsis", Blood Coagul Fibrinolysis, 24, pp.839~843 (2013)
- Nieuwenhuizen W., "Fibrinogen Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis", Thromb Haemost, 77, pp.1031~1033 (1997)
- Dempfle CE, "Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score", Thromb Haemost, 91, pp.812~818 (2004)
- Olson JD, "D-dimer: An overview of hemostasis and fibrinolysis, assays, and clinical applications", Adv Clin Chem, 69, pp.1~46 (2015)
- Qute Choi, "Changes in Plasma Levels of Natural Anticoagulants in Disseminated Intravascular Coagulation: High Prognostic Value of Antithrombin and Protein C in Patients with Underlying Sepsis or Severe Infection", Annals of Laboratory Medicine, 34(2), pp.85~91 (2014), 대한진단검사의학회
- Koyama K, "Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study", Crit Care, 18, pp.R13~ (2014)
- Gando S, "Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome", Thromb Haemost, 75, pp.224~228 (1996)
- Dempfle CE, "Point of care coagulation tests in critically ill patients", Semin Thromb Hemost, 34, pp.445~450 (2008)
- Sivula M, "Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulation", Blood Coagul Fibrinolysis, 20, pp.419~426 (2009)
- Haase N, "Thromboelastography in patients with severe sepsis: a prospective cohort study", Intensive Care Med, 41, pp.77~85 (2015)
- Müller MC, "Utility of thromboelastography and", or thromboelastometry in adults with sepsis: a systematic review, 2014, pp.18, R30~