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Respiratory Muscle Strength and Cough Capacity in Patients with Duchenne Muscular Dystrophy

강성웅|문재호|강연승|손홍석|박정현
연세대학교의과대학 (Yonsei University College of Medicine)|2006.04|Yonsei Medical Journal|제47권 제2호|pp. 184-190

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초록

The function of inspiratory muscles is crucial for effective cough as well as expiratory muscles in patients with Duchenne muscular dystrophy (DMD). However, there is no report on the correlation between cough and inspiratory muscle strength. To investigate the relationships of voluntary cough capacity, assisted cough techniques, and inspiratory muscle strength as well as expiratory muscle strength in patients with DMD (n= 32). The vital capacity (VC), maximum insufflation capacity (MIC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) were measured. Unassisted peak cough flow (UPCF) and three different techniques of assisted PCF were evaluated. The mean value of MICs (1918±586 mL) was higher than that of VCs (1474±632mL) (p< 0.001). All three assisted cough methods showed significantly higher value than unassisted method (212±52L/min) (F= 66.13, p<0.001). Combined assisted cough technique (both manual and volume assisted PCF; 286±41L/min) significantly exceeded manual assisted PCF (MPCF; 246±49L/ min) and volume assisted PCF (VPCF; 252±45L/min) (F= 66.13, p<0.001). MIP (34±13cmH2O) correlated significantly with both UPCF and all three assisted PCFs as well as MEP (27±10cmH2O) (p<0.001). Both MEP and MIP, which are the markers of respiratory muscle weakness, should be taken into account in the study of cough effectiveness.

Abstract

The function of inspiratory muscles is crucial for effective cough as well as expiratory muscles in patients with Duchenne muscular dystrophy (DMD). However, there is no report on the correlation between cough and inspiratory muscle strength. To investigate the relationships of voluntary cough capacity, assisted cough techniques, and inspiratory muscle strength as well as expiratory muscle strength in patients with DMD (n= 32). The vital capacity (VC), maximum insufflation capacity (MIC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) were measured. Unassisted peak cough flow (UPCF) and three different techniques of assisted PCF were evaluated. The mean value of MICs (1918±586 mL) was higher than that of VCs (1474±632mL) (p< 0.001). All three assisted cough methods showed significantly higher value than unassisted method (212±52L/min) (F= 66.13, p<0.001). Combined assisted cough technique (both manual and volume assisted PCF; 286±41L/min) significantly exceeded manual assisted PCF (MPCF; 246±49L/ min) and volume assisted PCF (VPCF; 252±45L/min) (F= 66.13, p<0.001). MIP (34±13cmH2O) correlated significantly with both UPCF and all three assisted PCFs as well as MEP (27±10cmH2O) (p<0.001). Both MEP and MIP, which are the markers of respiratory muscle weakness, should be taken into account in the study of cough effectiveness.

참고문헌 (26)

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관련 논문AI추천

How Respiratory Muscle Strength Correlates with Cough Capacity in Patients with Respiratory Muscle Weakness강성웅, 김동현, 박중현, 이상철, 최원아연세대학교의과대학 · Yonsei Medical Journal2010 · 제51권 제3호Analysis of Pulmonary Function Test in Korean Patients With Duchenne Muscular Dystrophy: Comparison of Foreign and Korean Reference Data김상훈, Je-Sang Lee, Myung Jun Shin, Soo-Yeon Kim, Tae Sik Bang, Woo Hyuk Choi, Yong Beom Shin대한재활의학회 · Annals of Rehabilitation Medicine2016 · 제40권 제5호Assisted Cough and Pulmonary Compliance in Patients with Duchenne Muscular Dystrophy강성웅, 강연승, 문재호, 유태원연세대학교의과대학 · Yonsei Medical Journal2005 · 제46권 제2호뒤시엔느 근 이영양증 환자에서 기능 수준과 측정 자세에 따른 최대호기유량, 1초간노력성호기량 및 최대기침유량의 변화김기송, 신헌석한국전문물리치료학회 · 한국전문물리치료학회지2009 · 제16권 제3호Clinical Implications of Routine Monitoring of Pulmonary Function and Ventilation in Patients with Duchenne Muscular Dystrophy강성웅, 이장우, 조한얼, 최원아연세대학교의과대학 · Yonsei Medical Journal2022 · 제63권 제6호A Comparison of Cough Assistance Techniques in Patients with Respiratory Muscle Weakness강성웅, 김선미, 원유희, 최원아연세대학교의과대학 · Yonsei Medical Journal2016 · 제57권 제6호

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