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Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

김세주|김영신|이홍식|김찬형
연세대학교의과대학 (Yonsei University College of Medicine)|2006.12|Yonsei Medical Journal|제47권 제6호|pp. 787-792

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참고문헌

주제분류의학일반

초록

Abstract

Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.

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관련 논문AI추천

한국인에서 도파민 D4 수용체 다형성과 Novelty Seeking 성격 특성의 연관성김린, 강화연, 변영찬, 서광윤, 이민수, 이헌정, 이홍석대한신경정신의학회 · 신경정신의학2002 · 제41권 제4호한국인에서 5-HT1Dβ 유전자다형성과 성격 특성김성준, 김세주, 김찬형, 이홍식, 조대연, 최낙경, 홍현주대한신경정신의학회 · 신경정신의학2005 · 제44권 제2호도파민 D2 수용체 다형성과 보상의존성 성격특성과의 관련성김린, 강이헌, 곽강호, 서광윤, 이민수, 이헌정대한생물정신의학회 · 생물정신의학2004 · 제11권 제1호한국 여성에서 5-HTTLPR 유전자 다형성과 성격특성의 연관성이소희, 이승민, 최종혁, 함병주대한생물정신의학회 · 생물정신의학2007 · 제14권 제4호Brain-Derived Neurotrophic Factor (BNDF) Val66Met 유전자 다형성과 성격 특성에 대한 연합연구류성곤, 안희범, 이민수, 조수민, 최명진, 최인근, 함병주대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호한국인 주의력결핍 과잉행동장애와 도파민 D5 수용체 유전자 다형성의 관련성 : 가족기반 연구 및 환자-대조군 연구강대희, 김붕년, 박태원, 배치운, 백소영, 서영주, 유일한, 유희정, 임명호, 조수철, 조은정대한신경정신의학회 · 신경정신의학2005 · 제44권 제1호

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