본문 바로가기
KERD
논문KCI 등재

한국인에서 5-HT1Dβ 유전자다형성과 성격 특성

Polymorphisms in 5-HT1Dβ Receptor Gene and Personality Traits in a Korean Population

0

조회

0

다운로드

0

인용

0

참고문헌

주제분류정신과학

초록

Abstract

Objectives:Recently, there has been a growing enthusiasm in biological approach to personality; the identification of genes responsible for particular personality traits. The aim of this study was to investigate the association between the 5-HT1Dβ G861C polymorphism and personality traits. Methods:We recruited 218 normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the HT1Dβ G861C polymorphism was genotyped by means of polymerase chain reaction and Homogeneous MassEXTEND method. We classified the subject into the GG, CG, and GG groups according to their genotypes. The differences in the temperament factors of the TCI between homozygote group (GG+CC genotype) and heterozygote group (CG genotype) were tested. Results:The heterozygote group had significantly lower Harm avoidance (HA) scores and higher Self-directedness scores(SD) than the homozygote group. Conclusion:In conclusion, we found some associations between the 5-HT1Dβ G861C polymorphism and the personality dimension HA and SD in a normal population.

참고문헌 (30)

  1. "Genes,environment,and personality", 264, pp.1700~1701 (1994)
  2. "A psychobiological modelof temperament and character", 50, pp.975~990 (1993)
  3. "A systematic method for clinical description and classificationof personality variants", 44, pp.573~588 (1987)
  4. paroxetine binding related to impulsive suicide attempts andborderline personality disorder, , 1998, 740~746
  5. "Lowering of serotonin by rapid tryptophan depletion increaseimpulsiveness in normal individuals", 164, pp.385~391 (2002)
  6. "Association of anxiety-related traits with a polymorphism in the serotonintransporter gene regulatory region", 274, pp.1527~1531 (1996)
  7. "Relationship between serotonin and the Temperament and CharacterInventory", 89, pp.29~37 (1998)
  8. "A polymorphism in the serotonin receptor 3A(HTR3A)geneand its association with harm avoidance in women", 60, pp.1017~1023 (2003)
  9. "A human serotonin 1D receptor variant(5HT1Dbeta)encoded by an intronless gene on chromosome 6", 89, pp.5522~5526 (1992)
  10. "Sumatriptan challengein bipolar patients with and without migraine:a neuroendocrinestudy of 5-HT1D receptor function", 17, pp.33~36 (2002)
  11. "5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder:further evidence from a family-basedassociation study", 7, pp.805~809 (2002)
  12. "Linkage of antisocial alcoholism to the serotonin 5-HT1B receptorgene in 2 populations", 55, pp.989~994 (1998)
  13. "The serotonin 5-HT1B receptor gene and attention deficit hyperactivitydisorder", 8, pp.98~102 (2003)
  14. "Polymorphism of the serotonin 5-HT1B receptor gene(HTR1B)associated with minimum lifetime body mass index inwomen with bulimia nervosa", 50, pp.640~643 (2001)
  15. "Substance abuse disorder and major depression areassociated with the human 5-HT1B receptor gene(HTR1B)G861Cpolymorphism", 28, pp.163~169 (2003)
  16. "Clinical study of Korean version Beck AnxietyInventory:comparisons between patients and non-patients groups", 16, pp.185~197 (1997)
  17. "Standization study of Korean version Beck Depression Inventory", 25, pp.487~500 (1986)
  18. "Reliability andvalidity of the Korean version of the temperament and character inventory", 43, pp.235~243 (2002)
  19. "No evidence of an association between 5HT1B receptor genepolymorphism and suicide victims in a Japanese population", 105, pp.343~345 (2001)
  20. "Allelic variation in 5-HT1A receptor expression is associated withanxiety- and depression-related personality traits", 110, pp.1445~1453 (2003)
  21. "5-HT2a receptor polymorphism gene in bipolar disorderand harm avoidance personality trait", 96, pp.360~364 (2000)
  22. "No association between the serotonin transporter gene regulatoryregion polymorphism and the Tridimensional Personality Questionnaire(TPQ)temperament of harm avoidance", 2, pp.224~226 (1997)
  23. "receptorfunction and personality traits in healthy subjects: a negativestudy", 68, pp.235~241 (2002)
  24. "Serotonergic genesand personality traits in the Korean population", 354, pp.2~5 (2004)
  25. "The HTR1B 861G>C receptor polymorphism among patientssuffering from alcoholism,major depression,anxiety disorders andnarcolepsy", 97, pp.1~10 (2000)
  26. "Role of serotonintransporter gene in temperament and character", 13, pp.312~328 (1999)
  27. "serotonin transporter promoter gene polymorphicregion(5-HTTLPR)and personality in female patients with seasonalaffective disorder and in healthy controls", 14, pp.53~58 (2004)
  28. "The neurobiology and pharmacology of depression:acomparative review of serotonin selective andtidepressants", 87, pp.540~552 (1997)
  29. "Prefrontal 5-HT2a receptor binding index,hopelessnessand personality characteristics in attempted suicide", 74, pp.149~158 (2003)
  30. "Relationship ofpsychopathology to the human serotonin 1B genotype and receptorbinding kinetics in post-mortem brain tissue", 21, pp.238~246 (1999)

관련 논문AI추천

이 간행물의 다른 논문 (17건)