본문 바로가기
KERD
논문KCI 등재

Telomerase reverse transcriptase in the regulation of gene expression

Yu-Sheng Cong|Junzhi Zhou|Deqiang Ding|Miao Wang
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2014.01|BMB Reports|제47권 제1호|pp. 8-14

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

Gene expressionTelomeraseTERT
주제분류화학

초록

Telomerase plays a pivotal role in the pathology of aging andcancer by maintaining genome integrity, controlling cellproliferation, and regulating tissue homeostasis. Telomerase isessentially composed of an RNA component, Telomerase RNAor TERC, which serves as a template for telomeric DNA synthesis,and a catalytic subunit, telomerase reverse transcriptase(TERT). The canonical function of TERT is the synthesis oftelomeric DNA repeats, and the maintenance of telomerelength. However, accumulating evidence indicates that TERTmay also have some fundamental functions that are independentof its enzymatic activity. Among these telomere-independentactivities of hTERT, the role of hTERT in genetranscription has been investigated in detail. Transcriptionalregulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT ingene transcription. This mini-review will focus on the role ofhTERT in gene transcription regulation, and discuss its possiblemechanisms.

Abstract

Telomerase plays a pivotal role in the pathology of aging andcancer by maintaining genome integrity, controlling cellproliferation, and regulating tissue homeostasis. Telomerase isessentially composed of an RNA component, Telomerase RNAor TERC, which serves as a template for telomeric DNA synthesis,and a catalytic subunit, telomerase reverse transcriptase(TERT). The canonical function of TERT is the synthesis oftelomeric DNA repeats, and the maintenance of telomerelength. However, accumulating evidence indicates that TERTmay also have some fundamental functions that are independentof its enzymatic activity. Among these telomere-independentactivities of hTERT, the role of hTERT in genetranscription has been investigated in detail. Transcriptionalregulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT ingene transcription. This mini-review will focus on the role ofhTERT in gene transcription regulation, and discuss its possiblemechanisms.

참고문헌 (57)

  1. Blackburn, E. H., "Recognition and elongation of telomeres by telomerase", Genome, 31, pp.553~560 (1989)
  2. Verdun, R. E., "Replication and protection of telomeres", Nature, 447, pp.924~931 (2007)
  3. Harley, C. B., "Telomerase and cancer therapeutics", Nat. Rev. Cancer, 8, pp.167~179 (2008)
  4. Jaskelioff, M., "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice", Nature, 469, pp.102~106 (2011)
  5. Dokal, I., "Dyskeratosis congenita", Hematology Am. Soc. Hematol. Educ. Program, 2011, pp.480~486 (2011)
  6. Ghosh, A., "Telomerase directly regulates NF-kappa B-dependent transcription", Nat. Cell Biol, 14, pp.1270~1281 (2012)
  7. Ding, D., "Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NFkappaB- dependent transcription", FASEB J, 27, pp.4375~4383 (2013)
  8. Park, J. I., "Telomerase modulates Wnt signalling by association with target gene chromatin", Nature, 460, pp.66~72 (2009)
  9. Choi, J. K., "TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program", Plos. Genet, 4, pp.0124~0138 (2008)
  10. Zhou, J., "Endoplasmic reticulum stress activates telomerase", Aging Cell (2013)[DOI]
  11. Fu, W., "The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function", J. Mol. Neurosci, 14, pp.3~15 (2000)
  12. Haendeler, J., "Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage", Arterioscler. Thromb. Vasc. Biol, 29, pp.929~935 (2009)
  13. Indran, I. R., "hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells", Cancer Res, 71, pp.266~276 (2011)
  14. Kovalenko, O. A., "A mutant telomerase defective in nuclear- cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction", Aging Cell, 9, pp.203~219 (2010)
  15. Cong, Y, "Actions of human telomerase beyond telomeres", Cell Res, 18, pp.725~732 (2008)
  16. Smith, L. L., "Telomerase modulates expression of growth-controlling genes and enhances cell proliferation", Nat. Cell Biol, 5, pp.474~479 (2003)
  17. Lindvall, C., "Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene", Cancer Res, 63, pp.1743~1747 (2003)
  18. Park, Y. P., "Up-regulation of Mac-2 binding protein by hTERT in gastric cancer", Int. J. Cancer, 120, pp.813~820 (2007)
  19. Jagadeesh, S., "Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1", Biochem. Biophys. Res. Commun, 347, pp.774~780 (2006)
  20. Perrault, S. D., "Global gene expression response to telomerase in bovine adrenocortical cells", Biochem. Biophys. Res. Commun, 335, pp.925~936 (2005)
  21. Young, J. I., "Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I", J. Biol. Chem, 278, pp.19904~19908 (2003)
  22. Masutomi, K., "The telomerase reverse transcriptase regulates chromatin state and DNA damage responses", Proc. Natl. Acad. Sci. U. S. A, 102, pp.8222~8227 (2005)
  23. Hanahan, D, "The hallmarks of cancer", Cell, 100, pp.57~70 (2000)
  24. Stewart, S. A., "Telomerase contributes to tumorigenesis by a telomere length-independent mechanism", Proc. Natl. Acad. Sci. U. S. A, 99, pp.12606~12611 (2002)
  25. Perkins, N. D., "The diverse and complex roles of NF-kappaB subunits in cancer", Nat. Rev. Cancer, 12, pp.121~132 (2012)
  26. Oeckinghaus, A., "Crosstalk in NF-kappaB signaling pathways", Nat. Immunol, 12, pp.695~708 (2011)
  27. Yin, L., "NF-kappa B regulates transcription of the mouse telomerase catalytic subunit", J. Biol. Chem, 275, pp.36671~36675 (2000)
  28. Akiyama, M., "Cytokines modulate telomerase activity in a human multiple myeloma cell line", Cancer Res, 62, pp.3876~3882 (2002)
  29. Zuo, Q. P., "NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepG(2) hepatoma cell line", Eur. J.Pharmacol, 672, pp.113~120 (2011)
  30. Ghosh, A., "Telomerase directly regulates NF-kappaB-dependent transcription", Nat. Cell Biol, 14, pp.1270~1281 (2012)
  31. Rentoukas, E., "Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome", PLoS One, 7, pp.e35739~ (2012)
  32. Gizard, F., "Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages", Arterioscler. Thromb. Vasc. Biol, 31, pp.245~252 (2011)
  33. Zhou, L., "Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity", Biochem. Biophys. Res. Commun, 386, pp.739~743 (2009)
  34. Liu, Z., "Telomerase reverse transcriptase promotes epithelial- mesenchymal transition and stem cell-like traits in cancer cells", Oncogene, 32, pp.4203~4213 (2013)
  35. Anastas, J. N., "WNT signalling pathways as therapeutic targets in cancer", Nat. Rev. Cancer, 13, pp.11~26 (2013)
  36. Behrens, J., "Functional interaction of beta-catenin with the transcription factor LEF-1", Nature, 382, pp.638~642 (1996)
  37. Clevers, H., "Wnt", beta-catenin signaling in development and disease, 2006, pp.127, 469~480
  38. Sarin, K. Y., "Conditional telomerase induction causes proliferation of hair follicle stem cells", Nature, 436, pp.1048~1052 (2005)
  39. Flores, I., "Effects of telomerase and telomere length on epidermal stem cell behavior", Science, 309, pp.1253~1256 (2005)
  40. Okamoto, N., "Maintenance of tumor initiating cells of defined genetic composition by nucleostemin", Proc. Natl. Acad. Sci. U. S. A, 108, pp.20388~20393 (2011)
  41. Zhang, Q., "STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes", Blood, 108, pp.1058~1064 (2006)
  42. Park, O. K., "In vitro activation of Stat3 by epidermal growth factor receptor kinase", Proc. Natl. Acad. Sci. U. S. A, 93, pp.13704~13708 (1996)
  43. Strong, M. A., "Phenotypes in mTERT(+)", (-) and mTERT(-), Mol. Cell. Biol, pp.2011, 31[DOI]
  44. Listerman, I., "An investigation of the effects of the telomerase core protein TERT on Wnt signaling in human breast cancer cells", Mol. Cell. Biol, pp.00844~00913 (2013)[DOI]
  45. Ding, D., "Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer", FEBS. J, 280, pp.3205~3211 (2013)
  46. Hoffmeyer, K., "Wnt", beta-catenin signaling regulates telomerase in stem cells and cancer cells, 2012, pp.336, 1549~1554
  47. Maida, Y., "An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA", Nature, 461, pp.230~235 (2009)
  48. Ridanpaa, M., "Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage- hair hypoplasia", Cell, 104, pp.195~203 (2001)
  49. Chang, D. D., "A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA", Science, 235, pp.1178~1184 (1987)
  50. Rosenbluh, J., "RMRP is a non-coding RNA essential for early murine development", PLoS One, 6, pp.e26270~ (2011)
  51. Sharma, N. K., "Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria", Nucleic Acids Res, 40, pp.712~725 (2012)
  52. Haendeler, J., "Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage", Arterioscler. Thromb. Vasc. Biol, 29, pp.929~935 (2009)
  53. Indran, I. R., "hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function and inhibits ROS-mediated apoptosis in cancer cells", Cancer Res, 71, pp.266~276 (2011)
  54. Massard, C., "hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway", Oncogene, 25, pp.4505~4514 (2006)
  55. Indran, I. R., "Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase", Mol. Aspects. Med, 31, pp.21~28 (2010)
  56. Bagheri, S., "Genes and pathways downstream of telomerase in melanoma metastasis", Proc. Natl. Acad. Sci. U. S. A, 103, pp.11306~11311 (2006)
  57. Li, S., "Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA", J. Biol. Chem, 280, pp.23709~23717 (2005)

관련 논문AI추천

Implications of telomerase reverse transcriptase in tumor metastasisJunzhi Zhou, Yongkang Zou, Yu-Sheng Cong생화학분자생물학회 · BMB Reports2020 · 제53권 제9호Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models성영훈, 이한웅, Muhammad Ali연세대학교의과대학 · Yonsei Medical Journal2014 · 제55권 제1호New Functions for TelomeraseWilliam C. Hahn대한암학회 · Cancer Research and Treatment2003 · 제35권 제6호Expressional Profiling of Telomerase and Telomere-Associated Molecules in the Rat Testis and Seminal Vesicle during Postnatal Developmental Period백행운, 서희정, 이기호, 이성규, 전용필, 전태훈, 최인호한국축산학회 · 한국축산학회지2011 · 제53권 제3호Multi-level remodeling of transcriptional landscapes in aging and longevityAlexandre Goumba, Bérénice A. Benayoun, Juan I. Bravo, Nirmal Kumar Sampathkumar, Prakroothi S. Danthi, Rochelle W. Lai, Ryan Lu생화학분자생물학회 · BMB Reports2019 · 제52권 제1호Relationship between Telomere Maintenance and Liver DiseaseAbbey Barnard, Ashley Moch, Sammy Saab거트앤리버 소화기연관학회협의회 · Gut and Liver2019 · 제13권 제1호

이 간행물의 다른 논문 (7건)

Role of vascular smooth muscle cell in the inflammation of atherosclerosis박성하, 임소연pp. 1-7Mutation of the lbp-5 gene alters metabolic output in Caenorhabditis elegans최은영, 백융기, Mo Xupp. 15-20Znf45l affects primitive hematopoiesis by regulating transforming growth factor-β signalingDachang Tao, Yongxin Ma, Sizhong Zhang, Shasha Bian, Ping Yang, Huaqin Sun, Huijuan Chen, Yunqiang Liupp. 21-26Over-expression of BvMTSH, a fusion gene for maltooligosyltrehalose synthase and maltooligosyltrehalose trehalohydrolase, enhances drought tolerance in transgenic riceYoun Hab Lee, 김정호, 이사라, 이충환, 정종주, 주정수, 최해정, 최양도, 송상익pp. 27-32Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancerWei Zhang, Xiaoyan Xin, BiLiang Chen, Xiuchun Qiu, Kuo Jian, Jia Li, Meng Li, Li Wei, Qiang Haopp. 33-38
원문 보기