Early Marker of Myocardial Deformation in Children with Duchenne Muscular Dystrophy Assessed Using Echocardiographic Myocardial Strain Analysis
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Purpose: As cardiomyopathy is more prevalent and currently the leading cause of death in Duchenne muscular dystrophy (DMD),early detection of myocardial involvement is important. The purpose of this study was to analyze myocardial strain in DMD children,for the possibility of early detection of myocardial dysfunction. Materials and Methods: We reviewed medical records of DMD patients who were >10 years of age (15.6±1.6 years, 12.5–18 years),from March 2013 to June 2014. Data of 24 DMD children who underwent echocardiography with three-layer specific myocardialstrain were compared with 24 controls (age: 9.3±4.0 years, 5.5–17 years). Results: Epicardial longitudinal strain was lower in DMD (DMD: -9.3±3.8%; control: -12.3±4.3%; p=0.012). Radial strain (DMD:24.1±11.1%; control: 37.3±25.9%; p=0.027) and strain rate (SR) (DMD: 1.68±0.91; control: 2.42±0.84; p=0.006) on parasternal shortaxis view were lower in DMD. Circumferential strains in the endocardium (DMD: -17.5±4.7%; control: -24.2±5.3%; p<0.001), myocardium(DMD: -12.7±3.8%; control: -18.0±4.0%; p<0.001), and epicardium (DMD: -8.4±4.0%; control: -12.2±5.0%; p=0.006) weresignificantly decreased in DMD. Circumferential SRs were lower in the endocardial (DMD: -1.46±0.38; control: -1.78±0.27;p=0.002) and myocardial layers (DMD: 1.02±0.27; control: -1.28±0.22; p=0.001). Conclusion: In DMD patients, deteriorations in myocardial circumferential strain might be an indicator for predicting cardiomyopathy.
Abstract
Purpose: As cardiomyopathy is more prevalent and currently the leading cause of death in Duchenne muscular dystrophy (DMD),early detection of myocardial involvement is important. The purpose of this study was to analyze myocardial strain in DMD children,for the possibility of early detection of myocardial dysfunction. Materials and Methods: We reviewed medical records of DMD patients who were >10 years of age (15.6±1.6 years, 12.5–18 years),from March 2013 to June 2014. Data of 24 DMD children who underwent echocardiography with three-layer specific myocardialstrain were compared with 24 controls (age: 9.3±4.0 years, 5.5–17 years). Results: Epicardial longitudinal strain was lower in DMD (DMD: -9.3±3.8%; control: -12.3±4.3%; p=0.012). Radial strain (DMD:24.1±11.1%; control: 37.3±25.9%; p=0.027) and strain rate (SR) (DMD: 1.68±0.91; control: 2.42±0.84; p=0.006) on parasternal shortaxis view were lower in DMD. Circumferential strains in the endocardium (DMD: -17.5±4.7%; control: -24.2±5.3%; p<0.001), myocardium(DMD: -12.7±3.8%; control: -18.0±4.0%; p<0.001), and epicardium (DMD: -8.4±4.0%; control: -12.2±5.0%; p=0.006) weresignificantly decreased in DMD. Circumferential SRs were lower in the endocardial (DMD: -1.46±0.38; control: -1.78±0.27;p=0.002) and myocardial layers (DMD: 1.02±0.27; control: -1.28±0.22; p=0.001). Conclusion: In DMD patients, deteriorations in myocardial circumferential strain might be an indicator for predicting cardiomyopathy.
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