Aldehyde Dehydrogenase 2 (ALDH2) Polymorphism and the Risk of Alcoholic Liver Cirrhosis among East Asians: A Meta-Analysis
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Purpose: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations betweenthe ALDH2 polymorphism and the risk of ALC. Materials and Methods: Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databasesup to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. Results: A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphismwas associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61–0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. Conclusion: The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
Abstract
Purpose: The aldehyde dehydrogenase 2 (ALDH2) gene has been implicated in the development of alcoholic liver cirrhosis (ALC) in East Asians. However, the results are inconsistent. In this study, a meta-analysis was performed to assess the associations betweenthe ALDH2 polymorphism and the risk of ALC. Materials and Methods: Relevant studies were retrieved by searching PubMed, Web of Science, CNKI, Wanfang and Veipu databasesup to January 10, 2015. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using either the fixed- or random effects model. Results: A total of twelve case-control studies included 1003 cases and 2011 controls were included. Overall, the ALDH2 polymorphismwas associated with a decreased risk of ALC (*1/*2 vs. *1/*1: OR=0.78, 95% CI: 0.61–0.99). However, in stratification analysis by country, we failed to detect any association among Chinese, Korean or Japanese populations. Conclusion: The pooled evidence suggests that ALDH2 polymorphism may be an important protective factor for ALC in East Asians.
참고문헌 (40)
- Rehm J, "Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders", Lancet, 373, pp.2223~2233 (2009)
- O’Shea RS, "Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease", Hepatology, 51, pp.307~328 (2010)
- Monzoni A, "Genetic determinants of ethanol-induced liver damage", Mol Med, 7, pp.255~262 (2001)
- Stickel F, "Genetic determinants of alcoholic liver disease", Gut, 61, pp.150~159 (2012)
- Yoshida A, "Human aldehyde dehydrogenase gene family", Eur J Biochem, 251, pp.549~557 (1998)
- Mizoi Y, "Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism", Alcohol Alcohol, 29, pp.707~710 (1994)
- Goedde HW, "Distribution of ADH2 and ALDH2 genotypes in different populations", Hum Genet, 88, pp.344~346 (1992)
- Chao YC, "Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients", Hepatology, 19, pp.360~366 (1994)
- Chao YC, "Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients", Hepatology, 25, pp.112~117 (1997)
- Chao YC, "Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis", Am J Gastroenterol, 95, pp.2958~2964 (2000)
- Chao YC, "Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver", Alcohol Alcohol, 38, pp.431~436 (2003)
- 기주영, "알코올 대사 효소들의 유전적 다형성이 음주 행태 및 간경변증 발생에 미치는 영향", Clinical and Molecular Hepatology, 9(2003), pp.89~97 (2003), 대한간학회
- 김명식, "알코올성 췌장염과 간경변 환자에서 알코올대사효소와 시토카인의 유전자 다형성", 대한소화기학회지, 43(6), pp.355~363 (2004), 대한소화기학회
- Lee HC, "Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population", J Korean Med Sci, 16, pp.745~750 (2001)
- Nagata N, "Relationship between serum levels of anti-low-density lipoproteinacetaldehyde-adduct antibody and aldehyde dehydrogenase 2heterozygotes in patients with alcoholic liver injury", Alcohol Clin Exp Res, 23(4 Suppl), pp.24S~28S (1999)
- Nagata N, "Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury", Alcohol Clin Exp Res, 26(8 Suppl), pp.11S~14S (2002)
- Yamauchi M, "Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis", Hepatology, 22(4 Pt 1), pp.1136~1142 (1995)
- Yamauchi M, "Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis", J Hepatol, 23, pp.519~523 (1995)
- Yokoyama A, "Genetic polymorphisms of alcohol dehydrogenase1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men", Alcohol Clin Exp Res, 37, pp.1391~1401 (2013)
- Day CP, "Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage", Hepatology, 14, pp.798~801 (1991)
- Frenzer A, "Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcoholinduced cirrhosis and chronic pancreatitis", Gastroenterol Hepatol, 17, pp.177~182 (2002)
- García-Bañuelos J, "Genetic polymorphisms of genes coding to alcohol-metabolizing enzymes in western Mexicans: association of CYP2E1*c2", CYP2E1*5B allele with cirrhosis and liver function, 2012, pp.36, 425~431
- Kato S, "Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism", Scand J Gastroenterol, 38, pp.886~893 (2003)
- Ohhira M, "Hepatocellular carcinoma associated with alcoholic liver disease:a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2", Alcohol Clin Exp Res, 20(9 Suppl), pp.378A~382A (1996)
- Tanaka F, "High incidence of ADH2*1", ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease, 1996, pp.23, 234~239
- Lau J, "Quantitative synthesis in systematic reviews", Ann Intern Med, 127, pp.820~826 (1997)
- Mantel N, "Statistical aspects of the analysis of data from retrospective studies of disease", J Natl Cancer Inst, 22, pp.719~748 (1959)
- DerSimonian R, "Meta-analysis in clinical trials", Control Clin Trials, 7, pp.177~188 (1986)
- Begg CB, "Operating characteristics of a rank correlation test for publication bias", Biometrics, 50, pp.1088~1101 (1994)
- Egger M, "Bias in metaanalysis detected by a simple, graphical test", BMJ, 315, pp.629~634 (1997)
- Eriksson CJ, "The role of acetaldehyde in the actions of alcohol (update 2000)", Alcohol Clin Exp Res, 25(5 Suppl ISBRA), pp.15S32S~ (2001)
- Yoshida A, "Genetics of human alcohol-metabolizing enzymes", Prog Nucleic Acid Res Mol Biol, 40, pp.255~287 (1991)
- Goedde HW, "Alcoholism: Biomedical and Genetic Aspects", pp.21~56 (1989), Pergamon Press
- Zintzaras E, "Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?", Hepatology, 43, pp.352~361 (2006)
- Li D, "Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians", Hum Genet, 131, pp.725~737 (2012)
- Enomoto N, "Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes", Alcohol Clin Exp Res, 15, pp.141~144 (1991)
- Thomasson HR, "Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men", Am J Hum Genet, 48, pp.677~681 (1991)
- Murayama M, "Clinical characteristics and disease course of alcoholics with inactive aldehyde dehydrogenase-2", Alcohol Clin Exp Res, 22, pp.524~527 (1998)
- Nuutinen H, "Determinants of blood acetaldehyde level during ethanol oxidation in chronic alcoholics", Alcohol Clin Exp Res, 7, pp.163~168 (1983)
- Yokoyama A, "Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men", Alcohol Clin Exp Res, 34, pp.1246~1256 (2010)
