Correlation between Infection with Multiple Respiratory Viruses and Length of Hospital Stay in Patients from Cheonan, Korea
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The length of hospital stay (LOS) for patients with respiratory virus infections has been reported to depend the virus type and infection severity. However, the impact of co-infections remains unclear. Patients with suspected respiratory virus infections, who visited Dankook University Hospital between December 2006 and February 2014, were included to examine the relationship between co-infections and LOS. Multiplex reverse transcriptase-polymerase chain reactions were used to identify the causative viruses. LOS was analyzed with respect to sex, age, virus, and co-infection. During this period, 5,310 out of the 8,860 patients (59.9%; median age, 1.5 years) were respiratory virus-positive. In respiratory virus-positive patients with single, double, and three-or-more infections, the average LOS was 7.3, 6.7, and 6.6 days, respectively. Longer LOS was observed for older patients and those with human coronavirus OC43 infections compared with adenovirus or respiratory syncytial virus A infections. LOS differed significantly according to age, virus type, and co-infection, but not between double and three or more infections.
Abstract
The length of hospital stay (LOS) for patients with respiratory virus infections has been reported to depend the virus type and infection severity. However, the impact of co-infections remains unclear. Patients with suspected respiratory virus infections, who visited Dankook University Hospital between December 2006 and February 2014, were included to examine the relationship between co-infections and LOS. Multiplex reverse transcriptase-polymerase chain reactions were used to identify the causative viruses. LOS was analyzed with respect to sex, age, virus, and co-infection. During this period, 5,310 out of the 8,860 patients (59.9%; median age, 1.5 years) were respiratory virus-positive. In respiratory virus-positive patients with single, double, and three-or-more infections, the average LOS was 7.3, 6.7, and 6.6 days, respectively. Longer LOS was observed for older patients and those with human coronavirus OC43 infections compared with adenovirus or respiratory syncytial virus A infections. LOS differed significantly according to age, virus type, and co-infection, but not between double and three or more infections.
참고문헌 (31)
- Asner SA, "Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis", PLoS One, 9, pp.e99392~ (2014)
- Nascimento MS, "High rate of viral identification and coinfections in infants with acute bronchiolitis", Clinics, 65, pp.1133~1137 (2010)
- Chawla R, "Predictors of mortality and length of stay in hospitalized cases of 2009 influenza A (H1N1): Experiences of a tertiary care center", Indian J Crit Care Med, 17, pp.275~282 (2013)
- Goka E, "Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalisation and mortality", Influenza Other Respir Viruses, 7, pp.1079~1087 (2013)
- Calvo C, "Multiple simultaneous viral infections in infants with acute respiratory tract infections in Spain", J Clin Virol, 42, pp.268~272 (2008)
- Miron D, "Sole pathogen in acute bronchiolitis: Is there a role for other organisms apart from respiratory syncytial virus?", Pediatr Infect Dis J, 29, pp.e7~e10 (2010)
- Richard N, "The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis", Pediatr Infect Dis J, 27, pp.213~217 (2008)
- Semple MG, "Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis", J Infect Dis, 191, pp.382~386 (2005)
- Hernes SS, "No impact of early real-time PCR screening for respiratory viruses on length of stay and use of antibiotics in elderly patients hospitalized with symptoms of a respiratory tract infection in a single center in Norway", Eur J Clin Microbiol Infect Dis, 33, pp.359~364 (2014)
- Menéndez R, "Initial risk class and length of hospital stay in community-acquired pneumonia", European Respiratory Journal, 18, pp.151~156 (2001)
- 이은경, "대구지역 단일병원에서 입원 환아의 호흡기 바이러스 역학 및 임상 양상: 2010-2012년", Yeungnam University Journal of Medicine, 30(2), pp.95~100 (2013), 영남대학교 의과대학
- 서진종, "광주지역 소아에서 유행한 호흡기바이러스 유행양상 분석", Infection and Chemotherapy, 40(4), pp.218~229 (2008), 대한감염학회
- Zhang D, "Epidemiology characteristics of respiratory viruses found in children and adults with respiratory tract infections in southern China", Int J Infect Dis, 25, pp.159~164 (2014)
- 서유빈, "Etiology and Clinical Outcomes of Acute Respiratory Virus Infection in Hospitalized Adults", Infection and Chemotherapy, 46(2), pp.67~76 (2014), 대한감염학회[DOI]
- Widmer K, "Respiratory syncytial virus- and human metapneumovirus- associated emergency department and hospital burden in adults", Influenza Other Respir Viruses, 8, pp.347~352 (2014)
- 윤가현, "호흡기세포융합 바이러스 아형에 따른 영아기 폐렴 및 모세기관지염의 임상 양상: 2010.2012 일개 삼차병원의 경험", Allergy Asthma & Respiratory Diseases, 1(1), pp.84~89 (2013), 대한 소아알레르기 호흡기학회
- Gilca R, "Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons", J Infect Dis, 193, pp.54~58 (2006)
- Wang C, "Comparison of patients hospitalized with influenza A subtypes H7N9, H5N1, and 2009 pandemic H1N1", Clin Infect Dis, 58, pp.1095~1103 (2014)
- Drews AL, "Dual respiratory virus infections", Clin Infect Dis, 25, pp.1421~1429 (1997)
- Papadopoulos NG, "Association of rhinovirus infection with increased disease severity in acute bronchiolitis", Am J Respir Crit Care Med, 165, pp.1285~1289 (2002)
- Echenique IA, "Clinical characteristics and outcomes in hospitalized patients with respiratory viral co-infection during the 2009 H1N1influenza pandemic", PLoS One, 8, pp.e60845~ (2013)
- Maletzky AJ, "Epidemiology of viral and mycoplasmal agents associated with childhood lower respiratory illness in a civilian population", J Pediatr, 78, pp.407~414 (1971)
- Portnoy B, "Multiple respiratory virus infections in hospitalized children", Am J Epidemiol, 82, pp.262~272 (1965)
- Martin ET, "Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children", Influenza Other Respir Viruses, 6, pp.71~77 (2012)
- Palomino MA, "Adenovirus and respiratory syncytial virus-adenovirus mixed acute lower respiratory infections in Chilean infants", Pediatr Infect Dis J, 23, pp.337~341 (2004)
- Flaujac C, "Platelets and viruses: an ambivalent relationship", Cell Mol Life Sci, 67, pp.545~556 (2010)
- Newburger PE, "Nelson textbook of pediatrics", pp.746~752 (2011), Elsevier Saunders
- 박인호, "호흡기바이러스 감염에 의한 혈액학적 합병증", Pediatric Infection and Vaccine, 20(3), pp.178~185 (2013), 대한소아감염학회
- 조경순, "2000-2002년 부산지역에서 분리한 인플루엔자바이러스의 특성 및 발생 양상", 대한임상검사과학회지, 35(1), pp.1~8 (2003), 대한임상검사과학회
- Esposito S, "Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses", Influenza Other Respir Viruses, 7, pp.18~26 (2013)
- Wishaupt JO, "Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial", Pediatrics, 128, pp.e1113~e1120 (2011)